Low serum uric acid concentration augments insulin effects on the prevalence of metabolic syndrome

Porchia, Leonardo M.; González-Mejia, M. Elba; Torres‐Rasgado, Enrique; Ruiz-Vivanco, Guadalupe; Pérez-Fuentes, Ricardo

doi:10.1016/j.dsx.2017.12.012

Cited by 8 publications

(7 citation statements)

References 34 publications

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“…The statistically extremely significant relationship between blood uric acid level and metabolic syndrome components was discovered. Similar findings were made byPorchia et al (2018) [25],Huang et al (2017)…”

supporting

confidence: 88%

Association Between Serum Uric Acid and Metabolic Syndrome Components at Tertiary Care Hospital, North West Rajasthan

Yadav

VYAS

Agrawal

2022

Asian J Pharm Clin Res

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Objective: The term “metabolic syndrome” (MetS) refers to a concept rather than a specific illness. All cardiovascular events seen in participants cannot be explained by the established risk factors for metabolic syndrome. We investigated the relationship between uric acid levels and the different elements of the metabolic syndrome. Methods: The Department of Medicine, S.P. Medical College, Bikaner, Rajasthan, conducted a case control study from January 2020 to December 2020 on 150 cases of metabolic syndrome as per NCEP ATP III definition criteria and harmonizing definition criteria, admitted in various wards, and 150 healthy individuals taken as controls selected by simple random sampling and matched for confounding factors. Results: Both the study group and the control group had comparable socio-demographics. In the metabolic group (study group), the prevalence of hyperuricemia was 20% with a mean of 6.00±0.98 mg/dL, compared to 22.3% in men and 16.07% in women. When the maximal number of metabolic syndrome components (4 or 5) were present, the mean blood uric acid level was 6.4 1.03 mg/dL (p = 0.001). Conclusion: The incidence of the metabolic syndrome and its elements was substantially correlated with serum uric acid levels.

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supporting

confidence: 88%

Association Between Serum Uric Acid and Metabolic Syndrome Components at Tertiary Care Hospital, North West Rajasthan

Yadav

VYAS

Agrawal

2022

Asian J Pharm Clin Res

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“…We were able to perform a meta‐analysis for the prognostic value of uric acid (hyperuricemia and continuous uric acid levels) and for the diagnostic value of hsCRP. We estimated the pooled OR for the association between hyperuricemia and MetS, adjusted for age and sex (four studies, 101 , 102 , 103 , 104 with threshold variability accepted of 10%, 238 OR 2.94, 95%CI 2.08–4.15); the pooled OR per unit increase in uric acid, unadjusted (three studies, 99 , 105 , 106 OR 1.086, 95%CI 1.066–1.106); and the pooled AUC for hsCRP, also unadjusted (three studies, 74 , 87 , 88 AUC 0.71, 95%CI 0.67–0.74). 99 , 106 Forest plots are shown in Figure 3 .…”

Section: Resultsmentioning

confidence: 99%

Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review

et al. 2021

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Childhood cancer survivors (CCS) are at increased risk to develop metabolic syndrome (MetS), diabetes, and cardiovascular disease. Common criteria underestimate adiposity and possibly underdiagnose MetS, particularly after abdominal radiotherapy. A systematic literature review and meta-analysis on the diagnostic and predictive value of nine newer MetS related biomarkers (adiponectin, leptin, uric acid, hsCRP, TNF-alpha, IL-1, IL-6, apolipoprotein B (apoB), and lipoprotein(a) [lp(a)]) in survivors and adult non-cancer survivors was performed by searching PubMed and Embase. Evidence was summarized with GRADE after risk of bias evaluation (QUADAS-2/QUIPS). Eligible studies on promising biomarkers were pooled. We identified 175 general population and five CCS studies. In the general population, valuable predictive biomarkers are uric acid, adiponectin, hsCRP and apoB (high level of evidence), and leptin (moderate level of evidence). Valuable diagnostic biomarkers are hsCRP, adiponectin, uric acid, and leptin (low, low, moderate, and high level of evidence, respectively). Meta-analysis showed OR for hyperuricemia of 2.94 (age-/ sex-adjusted), OR per unit uric acid increase of 1.086 (unadjusted), and AUC for hsCRP of 0.71 (unadjusted). Uric acid, adiponectin, hsCRP, leptin, and apoB can be alternative biomarkers in the screening setting for MetS in survivors, to enhance early identification of those at high risk of subsequent complications.

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“…Matsuura et al reported that 40% of patients with central obesity had hyperuricemia [22]. Previous studies showed that insulin resistance was significantly associated with hyperuricemia in patients with metabolic syndrome [23,24]. Furthermore, it is reported that hyperuricemia induces insulin resistance in vivo and in vitro, through the reactive oxygen species pathway, suggesting that insulin resistance is considered to play an important role in association of hyperuricemia and metabolic syndrome [25].…”

Section: Discussionmentioning

confidence: 99%

Lumbar epidural lipomatosis is associated with visceral fat and metabolic disorders

Morishita

Arai²,

Yoshii

et al. 2018

Eur Spine J

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Low serum uric acid concentration augments insulin effects on the prevalence of metabolic syndrome

Cited by 8 publications

References 34 publications

Association Between Serum Uric Acid and Metabolic Syndrome Components at Tertiary Care Hospital, North West Rajasthan

Association Between Serum Uric Acid and Metabolic Syndrome Components at Tertiary Care Hospital, North West Rajasthan

Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review

Lumbar epidural lipomatosis is associated with visceral fat and metabolic disorders

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