Aspects of urinary tract infections and antimicrobial resistance in hospitalized urology patients in Asia: 10-Year results of the Global Prevalence Study of Infections in Urology (GPIU)

Çek, Mete; Tandoğdu, Zafer; Wagenlehner, Florian M. E.; Bjerklund-Johansen, Truls; Nikfallah, Abolghasem; Kassem, Adham Mohamad; Aljubory, Ahmed Khalil; Salman, Ahmed; Kutmanova, Ainura; Usupbaev, A.Ch.; Natsheh, Ala Eddin Daud; Andreychikov, Alexander Vladimirovich; Plekhanov, Alexei Yurievich; Vinokurov, Alexey Dmitrievich; Dolgiy, A.; Afshari, Ali Taghizade; Naghoni, Ali; Dash, Amitabh; Zaitcev, Andrey Vladimirovych; Tsukanov, A. Yu.; Dashko, A.A.; Maliavin, Anton I.; Ghafouri, Ardala Abdolghafouri; Ali, Arif; Grabsky, Arthur; Rashed, Aso Omer; Bahadzor, Badrulhisham; Purnomo, Basuki Bambang; Gadamov, Begench Gurbangeldiyevich; Azari, Behrooz Rahnavardi; Shim, Bongsuk; Berejanski, Boris Vitalyevitch; Blas, Brian Penero; Han, Chang Hee; Lee, Chang-Ho; Xu, Chao; Ooi, Chong Chien; The, Chu Leong; Kim, Chul Sung; Le, Chuyen; Landau, Daniel; Rauniyar, Dilip; Khazaeli, Dinyar; Soebadi, Doddy M.; Lim, Dong-Hoon; Chiong, Edmund; Alexander, Egote Kofi; Kulchavenya, Ekaterina; Draghijeva, E.; Elsobky, Emad Rashad Mohamed; Khalid, Emad Eldin; Rashed, Fahimeh Kazemi; Wu, Fiona Mei Wen; Barakaev, Firuz; Shahbazyan, Garnik; Nakad, Haitham Saeed; Tajari, H R; Dahmash, Hani R.; Pliev, Hasan S.; Saloum, Hassan Mikhael; Kumon, Hiromi; Kiyota, Hiroshi; Hayami, Hiroshi; Inatomi, Hisato; Jeon, Ho Jong; Kim, Hong Bin; Lee, Hyun-Rim; Choe, Hyun‐Sop; Mah, I.S.F.; Aboyan, I.A.; Cho, InRae; Essilevski, Iouri M.; Khosropanah, Iradj; Абдуллин, И. И.; Hassan, Ismail; Palagin, Ivan; Kaneti, Jacob; Jeong, Jae Young; Alidjanov, Jakhongir F; Choi, Jin-Bong; Kim, Jong‐Il; Prodigalidad, Jose-Vicente Tablante; Sebastian, Joseph Philipraj; Makarycheva, Julia; Kim, Junmo; Oleg, Kagan Felixovich; Cho, Kang-Jun; Keyan, Karthi; Tanaka, Kazushi; Lu, Kevin; Ngoc, Khac Linh Tran; Kim, Kiho; Takahashi, Koichi; Dunets, Konstantin Antonovich; Zhu, Lan Ru; Vũ, Lê Nguyên; Arustamov, Levon Dm; Sinyakova, L. A.; Барашова, Л. П.; Ather, M. Hammad; Ma, Yu; Waze, Madhav Harihar; Zabaneh, Maher Fawzi; Baghinia, Mahmood Reza; Panigrahi, Manoj Kumar; Tayzon, Maria Fe; Serhal, Maroun; Moktash, Mayad Nouma; Elsayed, Medhat Ahmad Mohammad; Tahami, Mehrdad; Dan, Michael; Leh, Michael Yu; Frank, Michail; Baxi, Mihir V.; Kogan, Mikhail Josefovich; Wong, Ming Kui; Habous, Mohamad; Aslmonadi, Mohamadali; Helal, Mohamed Hani Abdulwahab; Salehi, Mohammad; Moslemi, Mohammad Kazem; Moein, Mohammad Reza; Aldahiri, Mohammad Khalil Ibrahim; Tanimura, Msasanobu; Valentinovich, Mstislav Morozov; Rafique, Muhammad; Ahmad, Mumtaz; Satyavani, Muppidi; Veeramani, Muthu Veeramani; Tabash, Nahed Ahmad Al; Alsaigh, Naimet Kamal; Altarwneh, Nayel Abdullah; Taneja, Neelam; Cayco, Nelson A.; Xuong, Nguyen Dinh; Viet, Nguyen Phu; Tran, Nguyen Van; Vorobyov, Nikolay Andreevich; Junejo, Noor Nabi; Sadeghifard, Nourkhoda; Kytaibekovich, Nurbek; Zuban, Oleg Nickolay; Sunga, Paul Anthony Lugue; Tamara, Perepanova Sergeevna; Aminovich, Polvonov Abror; Gyawali, Prem Raj; Dao, Quang Oanh; Mohammed, Radman Abdullah; Taghavi, Rahim Razavi; Kapoor, Rajni; Hakimzadeh, Ramin; Singh, Rachhpal S.; Raz, Raul; Gopakumarapillai, Ravisankar; Bharadwaj, Renu; aghelnezhad, Reza; Khammatov, Rinat; Salh, Riyadh Al; Gamazkov, Roman Vladislavovich; Santillan, Rosanna Tubo; Hamasuna, Ryoichi; Arasteh, Saeid; Makhsudov, S.A.; Chan, Sammy KK.; Lee, Sang Don; Pandey, Sanjay Kumar; Ishihara, Satoshi; Takahashi, Satoshi; Котов, С. В.; Baik, Seung Hyuk; Park, Seung Chol; Lee, Seung‐Ju; Eredjepov, Seydali; Habibollah, Seyed; Bhange, Shashikant R.; Kosugi, Shigeru; Park, Shin Jae; Lu, Shing-Hwa; Falahatkar, Siavash; Ghafouryan, Sobhan; Vladimirovna, Starodoubtsevan Nadia; Nazareth, Stephen; Chaimuangraj, Suchart; Lokwani, Sudhir Kumar; Raza, Syed Johar; Taghavi, Tahim Razavi; Qazi, Tahir Uddin; Sho, Takehiko; Перепанова, Т С; Sergeeuna, Tamara Perepanova; Khan, Taskeen Ahmad; Моисеенко, Т. Н.; Gul, Tawiz; Lin, Teng Lung; Gaviola, Teresita Tanaglin; Kim, T.H.; Wijesuriya, Thamara M; Ganesan, T.; Ueda, Tomohiro; Ha, U-Syn; Allahpour, Vafa Abd; Aboyan, V E; Startsev, Vladimir; Hasan, Waleed; Falou, Walid; Mirsya, Warli Syah; Qasim, W; Nakamura, Wataru; Wang, Wei; Cho, Won Yeol; Huang, Xiaoming; Cao, Yanwei; Farahat, Yasser; Na, Yong Gil; Cho, Yong-Hyun; Siegel, Yoram I.; Moussa, Youssef; Zhang, Xiangbo

doi:10.1016/j.jiac.2017.11.013

Cited by 35 publications

(31 citation statements)

References 38 publications

(39 reference statements)

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“…Similar observations were reported in the urine samples, globally. [15][16][17][18][19][20] Urinary tract infections are believed to be the second most predominant communitybased and nosocomial infections, worldwide. 21,22 These findings represent that urine and urinary tract environment demonstrate a higher prevalence of uropathogens due to the longer hospital stay, sexual activity, diabetes, hormonal imbalance, and genetic susceptibility.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Bacterial Pathogens and Antimicrobial Susceptibility Pattern in Bahrain Tertiary Care Hospital

2019

J Bah Med Soc

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Background: Breach of human cell integrity triggers the development of infection by pathogenic bacteria. Although, antibiotics are competent in containment of bacteria, the emergence of antibiotic resistance has led to aggravated diseases and mortality rate, significantly. Hence, current study considered evaluating the frequently encountered bacterial species isolated from the clinical samples, and to examine their antimicrobial susceptibility pattern. Methods: Current retrospective study was conducted during January-December 2017, in a tertiary care hospital. A total of 1931 isolates were included for microbiological analysis. Organisms isolated from the same site with similar sensitivity patterns for one month were excluded. Clinical samples were cultured on appropriate nutrient medium and characterized by microbiological techniques as well as automated system-Vitex analyzer. Antimicrobial susceptibility of few isolates was evaluated by Kirby-Bauer procedure and the rest by Vitex analyzer. Data were analyzed using R-3.4.1. Results: Majority of the clinical samples were urine (29.7 %) and wound swabs (10.5 %). Escherichia coli (31.3 %) and Klebsiella pneumoniae (14.4 %) were predominant among the Gram-negative isolates, whereas, Staphylococcus aureus (70.6 %) was prevalent among the Gram-positive isolates. Higher resistance pattern was observed towards β-lactams and cephalosporins, and greater susceptibility pattern was observed towards carbapenems. Bahraini patients showed higher predominance of extendedspectrum β-lactamase producers. Conclusion: Urine and wound samples were the prominent sources and S. aureus, E. coli, and K. pneumoniae were the predominant organisms. Isolates were highly resistant to β-lactams as well as cephalosporins and were susceptible to carbapenems. Sensible utilization of antibiotics and reporting the susceptibility and resistance pattern of common organisms, periodically, assist in controlling antimicrobial resistance.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Bacterial Pathogens and Antimicrobial Susceptibility Pattern in Bahrain Tertiary Care Hospital

2019

J Bah Med Soc

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“…The Infectious Diseases Society of America suggest a threshold of 20% as the resistance prevalence at which the agent is no longer recommended for empirical treatment of acute cystitis; this may no longer be feasible in the Asia-Pacific region, where Gram-negative resistance is escalating rapidly [1,5,6]. In fact, our study showed that carbapenems and amikacin were the only antibiotics with susceptibilities above 80%.…”

Section: Discussionmentioning

confidence: 72%

“…Ceftriaxone is currently one of the antibiotics recommended for the empiric treatment of UTI in the Asia-Pacific region [4]. However, cephalosporin and fluoroquinolone resistance are on the rise in the Asia-Pacific region [2,5,6]. This has led to concerns about the risks of the widespread use of empiric ceftriaxone therapy.…”

Section: Introductionmentioning

confidence: 99%

A Prediction Tool for the Presence of Ceftriaxone-Resistant Uropathogens upon Hospital Admission

Poh

Teng

et al. 2020

Antibiotics

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Antimicrobial resistance among uropathogens is a particularly pressing problem in the Asia-Pacific region. The objectives of this study were to determine the incidence and susceptibility of uropathogens upon hospital admission and to develop a risk-scoring model to predict the presence of ceftriaxone-resistance uropathogens (CrP). This was a retrospective observational cohort study of patients with a positive urine culture within 48 h of presentation at National University Hospital, Singapore between June 2015 and August 2015. Escherichia coli was the most common uropathogen isolated (51.7%), followed by Klebsiella pneumonia (15.1%) and Pseudomonas aeruginosa (8.2%). Overall, 372 out of 869 isolates (42.8%) were resistant to ceftriaxone. Hospitalization for ≥2 days within past 30 days, antibiotic use within the past 3 months and male gender were associated with the presence of CrP. A risk score based on these parameters successfully predicted CrP with an area under the curve of 0.68. The risk score will help clinicians to accurately predict antibiotic resistance at the individual patient level and allow physicians to safely prescribe empiric ceftriaxone in patients at low risk of CrP, thus reducing the antibiotic selection pressure that is driving carbapenem resistance in hospitals throughout Asia.

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“…Based on literature studies in 90% of urinary system infections in diabetic patients pathogenic agent is E. coli 17 . Antibiotic resistance of uropathogens involving in community-acquired and nosocomial urinary system infections is gradually increasing 18,19 . The increase in bacterial resistance rates may be due to the empirically medical prescription, individual self-medication or a low adherence to treatment, inefficient hospital infection control services and poor hygiene.…”

Section: Discussionmentioning

confidence: 99%

Ciprofloxacin is not a better choice in the patients with diabetes suffering urinary tract infection

Uğur¹,

Bal²,

Tartar³

et al. 2019

Dicle Tıp Dergisi

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Objective: The aim of this study is to determine antibacterial susceptibilities of Gram-negative bacteria isolated from diabetic and non-diabetic patients as infectious agents of community-acquired urinary tract infections (UTI) and to compare their rates of resistance to the antibiotics frequently used in empirical treatment. Results: In both diabetic and non-diabetic patient groups, most frequently Escherichia coli (88.5% in diabetic and 85.3% in non-diabetic groups) were isolated. In the diabetic group, microorganisms mostly demonstrated the highest rates of resistance against ampicillin, cephalosporins, ciprofloxacin, amoxicillin-clavulanic acid and in the non-diabetic group ampicillin, amoxicillin-clavulanic acid, cefuroxime and trimethoprim-sulfamethoxazole. Conclusion: Resistance to ciprofloxacin was at a significantly higher rate in the diabetic group. In diabetic patients, it will be more appropriate to give antibiotherapy in urinary system infections based on the antibacterial susceptibility test results.

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Aspects of urinary tract infections and antimicrobial resistance in hospitalized urology patients in Asia: 10-Year results of the Global Prevalence Study of Infections in Urology (GPIU)

Abstract: Uropathogens in many Asian countries had high resistance to broad-spectrum antibiotics. Knowledge of regional and local resistance data and prudent use of antibiotics are important for proper management of UTI in Asian countries.

Cited by 35 publications

References 38 publications

Prevalence of Bacterial Pathogens and Antimicrobial Susceptibility Pattern in Bahrain Tertiary Care Hospital

Prevalence of Bacterial Pathogens and Antimicrobial Susceptibility Pattern in Bahrain Tertiary Care Hospital

A Prediction Tool for the Presence of Ceftriaxone-Resistant Uropathogens upon Hospital Admission

Ciprofloxacin is not a better choice in the patients with diabetes suffering urinary tract infection

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