Baccharis trimera protects against ethanol induced hepatotoxicity in vitro and in vivo

Rabêlo, Ana Carolina Silveira; Lúcio, Karine de Pádua; Araújo, Carolina Morais; Araújo, Glaucy Rodrigues de; Miranda, Pedro Henrique de Amorim; Carneiro, Ana Cláudia Alvarenga; Ribeiro, Érica Milena de Castro; Silva, Breno de Melo; Lima, Wanderson Geraldo de; Costa, Daniela Caldeira

doi:10.1016/j.jep.2017.12.043

Cited by 28 publications

(13 citation statements)

References 55 publications

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“…In literature, several reports showed the antioxidant capacity of plant in the genus Baccharis . The free radical scavenger capacity of the DPPH radical of B. trimera aqueous extract (IC 50 values of 415 μg/mL) was reported [20,21]. Moreover, the antioxidant activity of the essential oil of B. trinervis through capture of the DPPH radical, and the model system of oxidation of β-carotene/linoleic acid were evaluated, obtaining IC 50 values of 49.0 mg/mL and 28.87 mg/mL, respectively [22].…”

Section: Resultsmentioning

confidence: 99%

Antioxidant, Gastroprotective, Cytotoxic Activities and UHPLC PDA-Q Orbitrap Mass Spectrometry Identification of Metabolites in Baccharis grisebachii Decoction

et al. 2019

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The decoction of the local plant Baccharis grisebachii is used as a digestive, gastroprotective, external cicatrizing agent and antiseptic in Argentine. A lyophilized decoction (BLD) from the aerial parts of this plant was evaluated regarding its anti-ulcer, antioxidant and cytotoxic activities and the bioactivities were supported by UHPLC-MS metabolome fingerprinting which revealed the presence of several small bioactive compounds. The antioxidant properties were evaluated by DPPH, TEAC, FRAP and lipoperoxidation inhibition in erythrocytes methods, and the antibacterial activity was evaluated according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. The BLD showed a moderate free radical scavenging activity in the DPPH (EC50 = 106 µg/mL) and lipid peroxidation in erythrocytes assays (67%, at 250 µg/mL). However, the BLD had the highest gastroprotective effect at a dose of 750 mg/kg with a ninety-three percent inhibition of damage through a mechanism that involve NO and prostaglandins using the ethanol-induced gastric damage in a standard rat model. On the other hand, BLD does not induce cytotoxic changes on human tumor and no-tumor cell lines at the concentrations assayed. Regarding the metabolomic analysis, thirty-one compounds were detected and 30 identified based on UHPLC-OT-MS including twelve flavonoids, eleven cinnamic acid derivatives, one coumarin, one stilbene and two other different phenolic compounds. The results support that the medicinal decoction of Baccharis grisebachii is a valuable natural product with gastroprotective effects and with potential to improve human health that opens a pathway for the development of important phytomedicine products.

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Section: Resultsmentioning

confidence: 99%

Antioxidant, Gastroprotective, Cytotoxic Activities and UHPLC PDA-Q Orbitrap Mass Spectrometry Identification of Metabolites in Baccharis grisebachii Decoction

et al. 2019

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“…Ethanol consumption induces CYP2E1, which leads to ROS production and NRF2 activation, and is implicated in the induction of alcohol dehydrogenase after chronic ethanol treatment [150]. Increasing evidence indicates that compounds that preserve or enhance NRF2 protect the liver from ALD, indicating that NRF2 protects cells from oxidative damage and inflammation induced by alcohol intoxication [151][152][153][154][155][156][157][158]. Ethanol abuse induces alterations in lipid metabolism that are associated with the disruption of NRF2 [148].…”

Section: Role Of Nrf2 In Alcoholic Liver Disease (Ald)mentioning

confidence: 99%

Molecular Mechanisms That Link Oxidative Stress, Inflammation, and Fibrosis in the Liver

Ramos‐Tovar¹,

2020

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Activated hepatic stellate cells (HSCs) and myofibroblasts are the main producers of extracellular matrix (ECM) proteins that form the fibrotic tissue that leads to hepatic fibrosis. Reactive oxygen species (ROS) can directly activate HSCs or induce inflammation or programmed cell death, especially pyroptosis, in hepatocytes, which in turn activates HSCs and fibroblasts to produce ECM proteins. Therefore, antioxidants and the nuclear factor E2-related factor-2 signaling pathway play critical roles in modulating the profibrogenic response. The master proinflammatory factors nuclear factor-κB (NF-κB) and the nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome may coordinate to produce and activate profibrogenic molecules such as interleukins 1β and 18, which effectively activate HSCs, to produce large amounts of fibrotic proteins. Furthermore, the NLRP3 inflammasome activates pro-caspase 1, which is upregulated by NF-κB, to produce caspase 1, which induces pyroptosis via gasdermin and the activation of HSCs. ROS play central roles in the activation of the NF-κB and NLRP3 signaling pathways via IκB (an inhibitor of NF-κB) and thioredoxin-interacting protein, respectively, thereby linking the molecular mechanisms of oxidative stress, inflammation and fibrosis. Elucidating these molecular pathways may pave the way for the development of therapeutic tools to interfere with specific targets.

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“…in mice and found that the extract induce a complex antioxidant pattern, reducing lipid peroxidation and increasing catalase activity, GSH and ascorbic acid levels in the liver. A study conducted with a hydroethanolic extract of B. crispa aerial parts showed a protective effect against ethanol‐induced hepatotoxicity in male rats [59] . The animals received ethanol 1 h after 600 mg/kg of the extract for 2 days (acute) or 28 days (chronic), reducing microesteatosis and improving lipid, hepatic and renal profiles, possibly through direct neutralizing effects or the inhibition of ROS production.…”

Section: Resultsmentioning

confidence: 99%

“…Male Fischer rats Absolute ethanol (5 mL/kg, p.o.) [59] Aerial parts infusion purified with ethanol ( Egletes viscosa (L.) Less.…”

Section: Male Albino Micementioning

confidence: 99%

Hepatoprotective Native Plants Documented in Brazilian Traditional Medicine Literature: Current Knowledge and Prospects

Arbo

Konrath

2022

Chemistry & Biodiversity

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The native flora of Brazil covers a large biodiversity of plants, some of which have important pharmacological properties. Ethnobotanical studies have established that the folk use of plants for hepatobiliary disorders is very common in Brazil. This review aimed to compile, describe and discuss the main native Brazilian medicinal plants used as hepatoprotective agents listed on 25 books by authors from various regions in the country. Based on the 153 species found, a comprehensive analysis of the most relevant scientific studies is presented, including Piper umbellatum, Echinodorus macrophyllus, Fevillea trilobata and Achyrocline satureioides. Some medicinal plants share both a large number of citations and scientific evidence to corroborate their hepatoprotective effects, including Solanum paniculatum, Baccharis crispa and Phyllanthus niruri, which could be of interest to develop new phytomedicines. Additionally, some active ingredients are indicated as being responsible for the liver protective effects described, particularly phenolic compounds (flavonoids, coumestans and lignans).

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Baccharis trimera protects against ethanol induced hepatotoxicity in vitro and in vivo

Cited by 28 publications

References 55 publications

Antioxidant, Gastroprotective, Cytotoxic Activities and UHPLC PDA-Q Orbitrap Mass Spectrometry Identification of Metabolites in Baccharis grisebachii Decoction

Antioxidant, Gastroprotective, Cytotoxic Activities and UHPLC PDA-Q Orbitrap Mass Spectrometry Identification of Metabolites in Baccharis grisebachii Decoction

Molecular Mechanisms That Link Oxidative Stress, Inflammation, and Fibrosis in the Liver

Hepatoprotective Native Plants Documented in Brazilian Traditional Medicine Literature: Current Knowledge and Prospects

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