The effect of brain-derived neurotrophic factor on radiation-induced neuron architecture impairment is associated with the NFATc4/3 pathway

Zhang, Qixian; Li, Xiaoyang; He, Rong; Sun, Rui; Ji, Shengjun; Wang, Bei; Tian, Ye

doi:10.1016/j.brainres.2017.12.032

Cited by 6 publications

(2 citation statements)

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“…Dysregulated signaling in the hippocampal microenvironment may disturb complex differentiation processes and may suppress the physiological maturation of progenitor cells to their neuronal phenotype [92]. In the hippocampal microenvironment, the control of cell proliferation and survival in stem cell niches depends on balanced signaling networks and is thus an important prerequisite for the orderly development and maintenance of tissues [99,100]. The transcription factor cAMP response element-binding (CREB) plays a crucial role in the proliferation, differentiation and survival of neuronal stem/progenitor cells [101].…”

Section: Age-dependent Effects Of Ir Exposure On Hippocampal Neurogen...mentioning

confidence: 99%

Radiation-Induced Brain Injury: Age Dependency of Neurocognitive Dysfunction Following Radiotherapy

Rübe,

Raid,

Palm

et al. 2023

Cancers

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Cranial radiotherapy is a known risk factor for neurocognitive impairment in cancer survivors. Although radiation-induced cognitive dysfunction is observed in patients of all ages, children seem to be more vulnerable than adults to suffering age-related deficits in neurocognitive skills. So far, the underlying mechanisms by which IR negatively influences brain functions as well as the reasons for the profound age dependency are still insufficiently known. We performed a comprehensive Pubmed-based literature search to identify original research articles that reported on age dependency of neurocognitive dysfunction following cranial IR exposure. Numerous clinical trials in childhood cancer survivors indicate that the severity of radiation-induced cognitive dysfunction is clearly dependent on age at IR exposure. These clinical findings were related to the current state of experimental research providing important insights into the age dependency of radiation-induced brain injury and the development of neurocognitive impairment. Research in pre-clinical rodent models demonstrates age-dependent effects of IR exposure on hippocampal neurogenesis, radiation-induced neurovascular damage and neuroinflammation.

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Section: Age-dependent Effects Of Ir Exposure On Hippocampal Neurogen...mentioning

confidence: 99%

Radiation-Induced Brain Injury: Age Dependency of Neurocognitive Dysfunction Following Radiotherapy

Rübe,

Raid,

Palm

et al. 2023

Cancers

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“…NFATc4 is encoded by a gene located on human chromosome 14 at q12 and was firstly isolated using a Jurkat T-cells and human peripheral blood lymphocytes (PBLs) cDNA library in 1995 [ 2 ]. NFATc4 is involved in several physiological processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems [ 3 – 6 ]. It is also reported that NFATc4 could take part in cell growth, cell migration, tumor metastasis, and patient survival recently.…”

Section: Introductionmentioning

confidence: 99%

Recent knowledge of NFATc4 in oncogenesis and cancer prognosis

et al. 2022

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Nuclear factor of activated T-cells, cytoplasmic 4 (NFATc4), a transcription factor of NFAT family, which is activated by Ca2+/calcineurin signaling. Recently, it is reported that aberrantly activated NFATc4 participated and modulated in the initiation, proliferation, invasion, and metastasis of various cancers (including cancers of the lung, breast, ovary, cervix, skin, liver, pancreas, as well as glioma, primary myelofibrosis and acute myelocytic leukemia). In this review, we cover the latest knowledge on NFATc4 expression pattern, post-translational modification, epigenetic regulation, transcriptional activity regulation and its downstream targets. Furthermore, we perform database analysis to reveal the prognostic value of NFATc4 in various cancers and discuss the current unexplored areas of NFATc4 research. All in all, the result from these studies strongly suggest that NFATc4 has the potential as a molecular therapeutic target in multiple human cancer types.

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