Intracranial metastasis in fibrolamellar hepatocellular carcinoma

Hammond, William J.; Lalazar, Gadi; Saltsman, James A.; Farber, Benjamin A.; Danzer, Enrico; Sherpa, Tshering C.; Banda, Charles D.; Andolina, Jeffrey R.; Karimi, Sasan; Brennan, Cameron; Torbenson, Michael; Quaglia, Michael P. La; Simon, Sanford M.

doi:10.1002/pbc.26919

Cited by 6 publications

(5 citation statements)

References 27 publications

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“…Seinfeld suggested that brain metastases from HCC could be secondary to lung deposits [20]. Hammond recommend that patients with lung metastases particularly undergo neuroimaging at time of diagnosis, even in the absence of symptoms [12]. Notably, our data considered the surveillance neuroimaging might necessary for both bone and lung metastases patients.…”

Section: Discussionmentioning

confidence: 92%

Predictive value of a nomogram for hepatocellular carcinoma with brain metastasis at initial diagnosis: A population-based study

Chen¹,

Huang²,

Shen³

et al. 2019

PLoS ONE

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BackgroundPopulation-based estimates of the incidence and prognosis of brain metastases at diagnosis of hepatocellular carcinoma (HCC) are lacking. The aim of this study was to characterize the incidence proportion and survival of newly diagnosed hepatocellular carcinoma with brain metastases (HCCBM).Materials and methodsData from Surveillance, Epidemiology, and End Results (SEER) program between 2010 and 2014 was evaluated. Patients with HCCBM were included. Multivariable logistic and Cox regression were performed to identify predictors of the presence of brain metastases at diagnosis and prognostic factors of overall survival (OS). We also built a nomogram based on Cox model to predict prognosis for HCCBM patients.ResultsWe identified 97 patients with brain metastases at the time of diagnosis of HCC, representing 0.33% of the entire cohort. Logistic regression showed patients with bone or lung metastases had greater odds of having brain metastases at diagnosis. Median OS for HCCBM was 2.40 months. Cox regression revealed unmarried and bone metastases patients suffered significantly shorter survival time. A nomogram was developed with internal validation concordance index of 0.639.ConclusionsThis study provided population-based estimates of the incidence and prognosis for HCCBM patients. The nomogram could be a convenient individualized predictive tool for prognosis.

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Section: Discussionmentioning

confidence: 92%

Predictive value of a nomogram for hepatocellular carcinoma with brain metastasis at initial diagnosis: A population-based study

Chen¹,

Huang²,

Shen³

et al. 2019

PLoS ONE

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“…Existen en la literatura pocos casos reportados de metástasis cerebrales del CFL. Sus presentaciones fueron sólido-quísticas, con desviación de la línea media y marcado realce poscontraste 8 .…”

Section: Estimados Editoresunclassified

“…El tratamiento inicial de elección para el CFL, siempre que sea posible, es la resección quirúrgica agresiva junto con linfadenectomía regional para la enfermedad primaria 9 . Es de gran importancia considerar la resección repetida o el trasplante hepático ortotópico para estos tumores, dada la falta de terapias alternativas eficaces 1,8 . Se sugiere realizar seguimiento de los pacientes durante al menos diez años, dada la alta tasa de recidiva 2 .…”

Section: Estimados Editoresunclassified

“…En la revisión de la bibliografía de otros tres casos reportados 8 no es clara la evolución del curso clínico de la enfermedad desde su inicio al desarrollo de metástasis cerebrales. El diagnóstico de este tumor generalmente se realiza en etapas avanzadas, dada la ausencia de sintomatología en estadios iniciales, es por esto que resulta relevante ampliar el estudio con neuroimágenes ante el diagnóstico de CFL.…”

Section: B a D Cunclassified

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Carcinoma fibrolamelar metastásico inusual: reporte de un caso

Laguna-Kirof,

Gómez-Bolívar,

Catalán

et al. 2024

RAR

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“…Results from a published population study showed that the 1-year OS and cancer-specific survival (CSS) was 5.9% and 6.3% in patients diagnosed with HCCBM (5). Among all HCCBM patients, most cases are located in supratentorial (11)(12)(13), other regions of metastatic HCC to the nervous system include skull (14,15), skull base (16,17), spine (14,18) and sella turcica (19), which lead to various nerve-related events. Recently, with the new drug sorafenib developed and shown to improve the outcome of advanced HCC, some investigators reported that the incidence of BM increased as more patients survived longer (20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Impact of homogeneous and heterogeneous risk factors on the incidence and prognosis of brain metastases in patients with hepatocellular carcinoma

et al. 2020

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Background: This study aimed to identify the incidence, risk factors, and survival outcome associated with brain metastases (BM) in hepatocellular carcinoma (HCC) patients using a large-scale population-based cancer registry database.Methods: Between 2010 and 2016, patients with BM from HCC were included using the Surveillance, Epidemiology, and End Results (SEER) program. The risk and prognostic factors for BM were recognized by multivariate logistic and Cox regression model analysis. The overall survival (OS) and cancer-specific survival (CSS) of HCC patients with BM were assessed using Kaplan-Meier curves with log-rank tests.Results: A total of 141 (0.33%) HCC patients detected with BM were included for analysis. Younger age, tumor pathological undifferentiation, no surgery, radiation therapy, no chemotherapy, synchronous bone, or lung metastases were positively associated with BM in the HCC cohort. The median OS and CSS of the BM patients were 3 months, while the corresponding survival time in HCC patients without BM was 13 and 23 months. Black race, tumor pathological undifferentiation, absence of chemotherapy, and concomitant lung metastases were independently associated with the worse survival.Conclusions: Although the overall prognosis of patients with BM from HCC was extremely poor, a list of homogeneous and heterogeneous risk factors were found to be significantly associated with the occurrence and prognosis of BM in HCC patients. These relevant factors may provide more valuable references for individualized treatment in clinical practice.

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Intracranial metastasis in fibrolamellar hepatocellular carcinoma

Cited by 6 publications

References 27 publications

Predictive value of a nomogram for hepatocellular carcinoma with brain metastasis at initial diagnosis: A population-based study

Predictive value of a nomogram for hepatocellular carcinoma with brain metastasis at initial diagnosis: A population-based study

Carcinoma fibrolamelar metastásico inusual: reporte de un caso

Impact of homogeneous and heterogeneous risk factors on the incidence and prognosis of brain metastases in patients with hepatocellular carcinoma

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