Comparative effect of<i>Camellia sinensis</i>teas on object recognition test deficit and metabolic changes induced by cafeteria diet

Soares, Melina Bucco; Ramalho, Juliana Bernera; Izaguirry, Aryele Pinto; Pavin, Natasha Frasson; Spiazzi, Cristiano Chiapinotto; Schimidt, Helen Lidiane; Mello‐Carpes, Pâmela Billig; Santos, Francielli Weber

doi:10.1080/1028415x.2017.1418726

Cited by 11 publications

(4 citation statements)

References 74 publications

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“…Hereafter, we present a model of cafeteria diet with palatable foods which are largely consumed by humans, and it is very palatable to rodents. This cafeteria diet model have been homogenized for a greater standardization and was used in few experiments in the literature, but the liver of the animals was not evaluated (Estadella et al, 2011;Schimidt et al, 2018;Rocha-Gomes et al, 2019;Soares et al, 2019;Teixeira et al, 2020). The aim of the present study was to evaluate the liver tissue of adult Wistar rats treated from birth to adulthood with cafeteria diet considering the biochemical, histopathological and redox state parameters of this organ.…”

Section: Introductionmentioning

confidence: 99%

Cafeteria diet from birth to adulthood promotes hepatic steatosis and redox imbalance in Wistar rats

Gomes

Costa

Rocha-Gomes

et al. 2020

NFS

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Purpose The purpose of this paper is to evaluate the pathological, biochemical and redox state parameters of liver tissue in Wistar rats treated from birth to adulthood (119 days) with cafeteria diet. Design/methodology/approach During the lactation, 6 liters of Wistar rats (dam + 8 pups each) were fed one of two diets: control (CTRL; n = 3) or cafeteria (CAF; n = 3) diets and water ad libitum. After weaning, the males were placed in individual cages, receiving the same diet offered to their respective dams (CTRL or CAF; n = 18) until adulthood. The following parameters were evaluated: absolute and relative liver weight; blood, liver and feces biochemistry; liver histology; and redox state of the liver. Findings When assessing the relative and absolute organ weight, no significant differences were found between the groups. The Cafeteria group exhibited higher values of serum LDL-c (p = 0.008), VLDL-c (p = 0.03) and triglycerides (p = 0.01), as well as several micro and macrovacuoles of fat accumulation, higher hepatic lipid (p = 0.03) and cholesterol (p = 0.0001) levels regarding Control group. Cafeteria group showed greater expression of glutathione-s-transferase (p = 0.03) and superoxide dismutase (p = 0.005) enzymes compared to the control group. In the case of the markers of oxidative stress, there was no difference between the groups. Originality/value A simple and standardized cafeteria diet caused an accumulation of fatty acids in liver tissue, inducing a state of hepatic steatosis besides an increased expression of antioxidant enzymes.

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Section: Introductionmentioning

confidence: 99%

Cafeteria diet from birth to adulthood promotes hepatic steatosis and redox imbalance in Wistar rats

Gomes

Costa

Rocha-Gomes

et al. 2020

NFS

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“…Studies have shown a significant increase in AChE activity in neurodegenerative diseases such as AD [ 202 ]. This increase may be related to abnormal neurotransmitter metabolism and disturbances in cholesterol homeostasis [ [203] , [204] , [205] ]. Disruption of cholesterol homeostasis may lead to abnormal changes in cell membranes, affecting neurotransmission [ 206 , 207 ].…”

Section: Discussionmentioning

confidence: 99%

The Intersection of cerebral cholesterol metabolism and Alzheimer's disease: Mechanisms and therapeutic prospects

Liu,

Liang,

Liu

et al. 2024

Heliyon

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“…The deleterious effect of the high-fat diet has been demonstrated in the study by Gonçalves et al (2017), in which the descendants of mothers who received a highfat diet had a reduction in the global levels of histone acetylation in the hippocampus of male offspring in adulthood, is linked to gene silencing related to brain function. Soares et al (2017), showed that cafeteria diet consumption in mices caused weight gain, body fat accumulation, increased glucose, cholesterol, and triglycerides, associated to recognition memory deficits and increased reactive species (RS) levels and acetylcholinesterase (AChE) activity in the hippocampus. However, white, green, red and black (Camellia sinensis) significantly reduced these levels, showing benefits.…”

Section: Discussionmentioning

confidence: 99%

Purple grape juice consumption during the gestation reduces acetylcholinesterase activity and oxidative stress levels provoked by high-fat diet in hippocampus from adult female rats descendants

Proença

Gonçalves

Schmitz

et al. 2021

An. Acad. Bras. Ciênc.

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The enzyme acetylcholinesterase participates in the end of cholinergic transmission and it has been shown that its activity is increased in some diseases that affect the brain, including Alzheimer disease. The objective of this study was to investigate the effect of purple grape juice consumption with or without high-fat diet in the gestational and lactation period on acetylcholinesterase activity and oxidative stress parameters in the hippocampus of female descendants. During pregnancy and lactation, 40 female Wistar rats received a control diet or a high-fat diet, with half of them receiving grape juice. After lactation, the female descendants received water and control diet in ad libitum until euthanasia on the 120 postnatal day. Hippocampus from were removed for analysis of AChE activity, protein oxidation and lipid peroxidation. It was observed that high-fat diet consumption during the pregnancy increased the AChE activity and the grape juice reduced this activity in descendants. The same was observed in protein oxidation, the descendants from high-fat diet had signifi cantly highest values, and grape juice decreased the levels. We conclude that dietary choices during pregnancy can alter the acetylcholinesterase levels and grape juice is an important alternative to improve this function in adulthood.

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Comparative effect ofCamellia sinensisteas on object recognition test deficit and metabolic changes induced by cafeteria diet

Abstract: According to the results obtained it is possible to conclude that green tea was better than other teas in reducing effects of the CD model, being able to protect a greater number of parameters.

Cited by 11 publications

References 74 publications

Cafeteria diet from birth to adulthood promotes hepatic steatosis and redox imbalance in Wistar rats

Cafeteria diet from birth to adulthood promotes hepatic steatosis and redox imbalance in Wistar rats

The Intersection of cerebral cholesterol metabolism and Alzheimer's disease: Mechanisms and therapeutic prospects

Purple grape juice consumption during the gestation reduces acetylcholinesterase activity and oxidative stress levels provoked by high-fat diet in hippocampus from adult female rats descendants

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