Treatment of acute kidney injury complicating septic shock with EMiC2 high-cutoff hemofilter: Case series

Shum, Hoi‐Ping; Chan, King‐Chung; Yan, Wei; Chan, Tak Mao

doi:10.4103/ijccm.ijccm_338_17

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…In recent times, many researchers pay attention to the technological characteristics of the filters possessing the properties of sorbents [ 137 – 139 ]. Criteria of the efficacy of the continuous RRT method used to treat patients with SAP are very important.…”

Section: Hemofiltration and Hemodiafiltration In Severe Acute Pancreatitismentioning

confidence: 99%

Hemofiltration in Patients with Severe Acute Pancreatitis (Review)

et al. 2020

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Questions regarding the application of extracorporeal detoxification to patients with severe acute pancreatitis have been considered. Hemodialysis, the historically first method of extracorporeal detoxification for such patients, has been also described in the review. Appropriateness of using renal replacement therapy methods and among them continued renal replacement therapy has been shown. Hemofiltration and hemodiafiltration technologies are described in detail including different modes of their application and the possibility of using various types of filters. Available data on hemofiltration for patients with severe acute pancreatitis have been analyzed. Great attention is paid to the unsolved aspects of hemofiltration in severe acute pancreatitis such as determining renal and extrarenal indices; time of starting hemofiltration; selection of volume replacement modes and a buffer system; procedure duration; anticoagulation measures, defining criteria to assess the adequacy of hemofiltration, state severity, and organ dysfunction degree. Further multicenter investigations are necessary to be able to assess the efficacy of the hemofiltration procedures on the basis of the thoroughly worked out and pathogenically grounded protocol using adequate control methods taking into consideration endogenic intoxication phases and intensity of the multiple organ failure syndrome.

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Section: Hemofiltration and Hemodiafiltration In Severe Acute Pancreatitismentioning

confidence: 99%

Hemofiltration in Patients with Severe Acute Pancreatitis (Review)

et al. 2020

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“…EMIC-2 is a CVVHDF polysulfone structure filter which is highly effective in infiltrating medium-sized molecules (~40 kDa) with high biocompatibility and running effectively even in low blood flow (7). On the other hand, the AV600S filter is a CVVHDF filter with an infiltrating threshold of molecule of 30 kDa, which preserves proteins, such as albumin and other large molecules, and cellular blood components (8).…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Continuous Venovenous Hemodiafiltration with Cytokine Filter on Sepsis

Avcı¹

2019

Erciyes Med J

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Objective: Continuous renal replacement therapy is made with high biocompatibility membranes that have high current power by using diffusion and convection together or separately. The aim of the present study was to compare the EMIC-2 and AV600S filters used for continuous venovenous hemodiafiltration (CVVHDF) with respect to the effects on sepsis, the elimination of toxins that are elevated due to acute renal injury, and the effects on inflammatory mediators in severe sepsis. Materials and Methods: The study included 38 patients who were diagnosed with severe sepsis and were treated with hemodiafiltration in the intensive care unit. Acute Physiology and Chronic Health Evaluation-2 (APACHE-2) and Sequential Organ Failure Assessment (SOFA) scores of the patients were calculated before CVVHDF starts. Hematocrit (Hct), white blood cell, blood pressure, heart rate, and body temperature values were measured and recorded. Procalcitonin (PCT), tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, and IL-1 values on blood were also recorded before the process and at 8, 16, and 24 h of the process. Results: When the AV600S filtered and EMIC-2 filtered groups are compared, TNF-α values are low in the EMIC-2 filtered group (p<0.05). There is no significant difference between the groups with respect to the measurements about APACHE-2, SOFA, IL-1β, IL-6, PCT, Hct, body temperature, mean blood pressures, and heart rate. Conclusion: We think that the filters do not cause a significant change on the elimination of inflammatory cytokines, except TNF-α, on limited numbers of patients who have sepsis with acute renal injury undergoing CVVHDF with EMIC-2 and AV600S.

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Hemodialysis with High Cut-Off Hemodialyzers in Patients with Multi-Drug Resistant Gram-Negative Sepsis and Acute Kidney Injury: A Retrospective, Case-Control Study

Chelazzi

Villa

DʼAlfonso³

et al. 2016

Blood Purif

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Background: Hemodialysis with high cut-off continuous veno-venous hemodialyzer (HCO-CVVHD) removes mediators of organ dysfunction during sepsis. This study assessed the clinical effects of HCO-CVVHD as compared to high-flux (HF) membranes during gram-negative sepsis. Methods: Intensive care unit (ICU), septic patients treated with HCO-CVVHD or HF-CVVHDF for AKI were retrospectively observed (January 2013-December 2014). Mechanical ventilation, vasopressors' requirements, ICU length of stay (LOS) and ICU in-hospital mortality were compared between groups. Results: Sixteen HCO and 8 HF patients were observed. Isolated pathogens included Klebsiella pneumoniae, Acinetobacter baumannii, Escherichia coli and Pseudomonas aeruginosa. Median ratios of days-on-vasopressors and days-on-mechanical ventilation/ICU-LOS were 0.5, 1 and 0.8, 1 for HCO and HF groups (p < 0.03), respectively. ICU-LOS was 16 and 9 days (HCO- and HF-group, p = 0.03). ICU mortality rates were 37.5 and 87.5% for HCO and HF groups, respectively (p = 0.03). No statistical difference was found in in-hospital morality. Conclusion: Patients in HCO-CVVHD group spent lesser number of days on vasopressors and mechanical ventilation as a ratio to total ICU-LOS. In the same group, a reduction in ICU mortality was observed.

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Treatment of acute kidney injury complicating septic shock with EMiC2 high-cutoff hemofilter: Case series

Cited by 5 publications

References 43 publications

Hemofiltration in Patients with Severe Acute Pancreatitis (Review)

Hemofiltration in Patients with Severe Acute Pancreatitis (Review)

The Efficacy of Continuous Venovenous Hemodiafiltration with Cytokine Filter on Sepsis

Hemodialysis with High Cut-Off Hemodialyzers in Patients with Multi-Drug Resistant Gram-Negative Sepsis and Acute Kidney Injury: A Retrospective, Case-Control Study

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