Re-emergence of pneumococcal colonization by vaccine serotype 19F in persons aged ≥5 years after 13-valent pneumococcal conjugate vaccine introduction—Alaska, 2008–2013

Gounder, Prabhu; Bruden, Dana; Rudolph, Karen; Zulz, Tammy; Hurlburt, Debby; Thompson, Gail G.; Bruce, Michael G.; Hennessy, Thomas W.

doi:10.1016/j.vaccine.2017.12.035

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…Serotypes 14, 6A/B, and 19F were observed among highly resistant isolates with penicillin MICs ≥ 32. Dissemination of 19F isolates has increased in many parts of the world, and they have become resistant to penicillin (30)(31)(32). In this study, all 19F isolates were resistant to penicillin.…”

Section: Discussionmentioning

confidence: 62%

Characterization of Blood-isolated, Penicillin-Nonsusceptible Streptococcus pneumoniae From Children Between 2014 and 2018 in Bojnurd, Iran

Azimian

Khosrojerdi

Kebriaei

et al. 2021

Jundishapur J Microbiol

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Background: Streptococcus pneumonia is one of the common bacterial pathogens in pediatrics. In this study, we performed antimicrobial susceptibility testing, serotyping, and molecular typing of blood-isolated strains of pneumococci in Bojnurd. Objectives: In the current study, blood-isolated, penicillin-nonsusceptible Streptococcus pneumoniae strains were subjected to antimicrobial susceptibility testing and typing of capsular polysaccharides using the quelling reaction and PCR method, as well as genotyping using the Multi Locus Sequence Typing (MLST) method. Methods: In this study, 51 S. pneumonia strains were isolated from blood samples of children less than five-years-old in 2014 - 2018. Antibiogram was performed using the Kirby-Bauer method. All of the isolates were serotyped by the Quelling reaction and PCR. The MLST method was applied to determine the molecular types. Results: Our study revealed that the most common serotypes of blood-isolated pneumococci were 19A, 6A/B, 1, 23F, 19F, 14, 15B/C, and 15A, and the common serotypes in Penicillin-nonsusceptible pneumococci (PNSP) isolates were 19F, 19A, 23F, 14, and finally 15A, 6A/B, 1, and 15B/C. The MLST analysis of PNSP isolates revealed that three highly resistant isolates with MIC ≥ 16 belonged to Sweden15A-25-19A (ST63), Taiwan19F-14-1 (ST236), and Taiwan19F-14 (ST236) clones. Conclusions: Regarding the common serotypes in this study, it seems that PCV-13 is a suitable choice for vaccination in this area. We also observed a high prevalence of PNSP and MDR strains between 2014 and 2018. It seems that the Taiwan19F-14 clone and its related STs played an essential role in the diffusion of antibiotic-resistant S. pneumonia isolates in Bojnurd.

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Section: Discussionmentioning

confidence: 62%

Characterization of Blood-isolated, Penicillin-Nonsusceptible Streptococcus pneumoniae From Children Between 2014 and 2018 in Bojnurd, Iran

Azimian

Khosrojerdi

Kebriaei

et al. 2021

Jundishapur J Microbiol

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“…Recent data on CAP episodes from different geographical areas show that serotype 19F is the second serotype in frequency among CAP episodes and is mostly associated with penicillin non-susceptibility [25]. An increase in the frequency of colonization by serotype 19F pneumococci has also been reported in Alaska which could be related to the introduction of a new genotype and subsequent reduced effectiveness of PCV7 [26]. In the USA, the number of serotype 19F isolates causing pneumococcal pneumonia in adults increased over the period 2009-2017 [27].…”

Section: Discussionmentioning

confidence: 99%

Serotypes in Adult Pneumococcal Pneumonia in Spain in the Era of Conjugate Vaccines

et al. 2021

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We studied changes in serotype distribution and antimicrobial susceptibility in adult pneumococcal pneumonia in Spain (2011–2019). Among 895 pneumococci collected (433 bacteremic [BPP] and 462 non-bacteremic [non-BPP]), serotypes 3 (17%), 19A (10%), 8 (6.7%) and 11A (6.7%) were the most frequent. Serotypes 16F, 19A and 24F were associated with old people (≥65) and serotypes 4, 7F, 8, 12F and 19F to young adults. Serotypes 12F, 24F and 1 were significantly more frequent in BPP and serotypes 11A, 23A and 19F in non-BPP. Amoxicillin resistance was higher in non-BPP (17% vs. 11%) while penicillin non-susceptibility (37% vs. 24%) and macrolide resistance (29% vs. 14%) were higher in older adults. In the period 2017–2019, the vaccine coverages were: 32% (PCV13), 39% (PCV15), 65% (PCV20) and 69% (PPV23). Differences were found in serotype composition and antimicrobial resistance by age and type of infection. The maintenance of serotype 3 as a leading cause of adult pneumococcal pneumonia and the increase in highly invasive (serotype 8) or antimicrobial-resistant (serotype 11A) serotypes is worrisome. Further studies will be required to analyse the impact of the upcoming broader conjugate vaccines.

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“…Many studies, because 19F serogroup frequently is appeared as a cause of breakthrough infection, suggest that the vaccinated individuals may have a higher serum antibody requirement for 19F serogroups infection to protect the host compared to other serogroups; however, the vaccine response has been shown to provide a protective threshold of immune response development to all serogroups. 10 Pneumococcal antibiotic susceptibility is of substantial issue. In our study, it was observed that three isolates (33.4%) were resistant, and one isolate (11.2%) was intermediate susceptible to penicillin.…”

Section: Discussionmentioning

confidence: 99%

One year period of invasive pneumococcal disease in children from a tertiary care hospital in Turkey in the post-vaccine era

Üstündağ

Karadağ‐Öncel

Sen-Tas

et al. 2020

Human Vaccines & Immunotherapeutics

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The incidence of invasive pneumococcal disease (IPD) has decreased after pneumococcal conjugate vaccine used; however, a breakthrough infection may still be seen after vaccination. In this study, eight pediatric inpatients and nine episodes with IPD in our center were included. Their age and gender, diagnoses, facilitating factors, the status of immunization and the antibiotic resistance of Pneumococci, serotypes of Pneumococci were noted. The isolates were subjected to disc susceptibility tests for penicillin, macrolides, and fluoroquinolones, according to the guidelines of the Clinical and Laboratory Standards Institute. Of the vaccinated seven cases, four of them (57.1%) developed IPD which their serogroups were in vaccine content. It was observed that all four cases in question had an underlying facilitating factor. Pneumococcal antibiotic susceptibility is also crucial. Three of nine isolates (33.4%) were resistant, and one isolate (11.2%) was intermediate susceptible to penicillin. Six of the nine isolates (66.7%) had macrolide resistance in our investigation. Invasive pneumococcal infections with serogroups that exist in pneumococcal conjugate vaccine content may occur in vaccinated individuals.

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Re-emergence of pneumococcal colonization by vaccine serotype 19F in persons aged ≥5 years after 13-valent pneumococcal conjugate vaccine introduction—Alaska, 2008–2013

Cited by 6 publications

References 20 publications

Characterization of Blood-isolated, Penicillin-Nonsusceptible Streptococcus pneumoniae From Children Between 2014 and 2018 in Bojnurd, Iran

Characterization of Blood-isolated, Penicillin-Nonsusceptible Streptococcus pneumoniae From Children Between 2014 and 2018 in Bojnurd, Iran

Serotypes in Adult Pneumococcal Pneumonia in Spain in the Era of Conjugate Vaccines

One year period of invasive pneumococcal disease in children from a tertiary care hospital in Turkey in the post-vaccine era

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