Simultaneous determination of inorganic anions and cations by supercritical fluid chromatography using evaporative light scattering detection

Foulon, Catherine; Giulio, Pauline Di; Lecoeur, Marie

doi:10.1016/j.chroma.2017.12.047

Cited by 18 publications

(2 citation statements)

References 39 publications

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“…The most common analytical techniques used for direct counterion assays are ion chromatography (IC) [14][15][16][17][18] and either high-performance liquid chromatography (HPLC) or supercritical fluid chromatography (SFC) paired with an aerosol-based detector, such as evaporative light scattering detection (ELSD) [19][20][21][22] or charged aerosol detection (CAD). [13,[23][24][25][26] These techniques have some limitations such as (1) method development may not be straightforward with specific chromatographic conditions, such as column selection, generally needed for each new compound;…”

Section: Introductionmentioning

confidence: 99%

“…The most common analytical techniques used for direct counterion assays are ion chromatography (IC) [ 14–18 ] and either high‐performance liquid chromatography (HPLC) or supercritical fluid chromatography (SFC) paired with an aerosol‐based detector, such as evaporative light scattering detection (ELSD) [ 19–22 ] or charged aerosol detection (CAD). [ 13,23–26 ] These techniques have some limitations such as (1) method development may not be straightforward with specific chromatographic conditions, such as column selection, generally needed for each new compound; (2) the instruments are relatively specialized and moderately expensive, precluding routine availability in smaller, less well‐equipped academic, government, and industrial laboratories; (3) IC components are often sensitive to high levels of organic modifiers that may be needed to enable solubility of compounds for analysis; and (4) aerosol‐based detectors can exhibit robustness issues due to non‐volatile impurities present in HPLC eluents or as system contaminants.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative nuclear magnetic resonance of chloride by an accurate internal standard approach

Wood

Poggetto

Wang

et al. 2022

Magnetic Reson in Chemistry

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Chloride is the most common counterion used to improve aqueous solubility and enhance stability of small molecule active pharmaceutical ingredients. While several analytical techniques, such as titration, HPLC with charged aerosol detection, and ion chromatography, are currently utilized to assay the level of chloride, they have notable limitations, and these instruments may not be readily available. Here, we present a generally applicable 35 Cl solution NMR method to assay the level of chloride in pharmaceutical compounds. The method uses KClO 4 as an internal standard for improved accuracy in comparison with external standard methods, and it was found to be robust, linear over three orders of magnitude, precise (<3% RSD), and accurate (<0.5% absolute error).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantitative nuclear magnetic resonance of chloride by an accurate internal standard approach

Wood

Poggetto

Wang

et al. 2022

Magnetic Reson in Chemistry

View full text Add to dashboard Cite

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Green Chromatography and Related Techniques

Aly¹,

Górecki²

2019

Green Chemistry and Sustainable Technology

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Current trends in supercritical fluid chromatography

West

2018

Anal Bioanal Chem

164

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Supercritical fluid chromatography (SFC), which employs pressurized carbon dioxide as the major component of the mobile phase, has been known for several decades but has faced a significant resurgence of interest in the recent years, thanks to the development of modern instruments to comply with current expectations in terms of robustness and sensitivity. This review is focused on the recent literature, specifically since the introduction of modern systems but in relation to older literature, to identify the changing trends in application domains. Typically, natural products, bioanalysis, food science, and environmental analyses are all strongly increasing. Together with reduced extra-column volumes in the instruments, the advent of sub-2-μm particles and superficially porous particles in the stationary phases is favoring ultra-high-performance SFC (UHPSFC) allowing for improved resolution and faster analyses, but without the constraints of viscous liquids encountered in ultra-high-performance liquid chromatography (UHPLC). Hyphenation to mass spectrometry is also more frequent and opened the way to new application domains, and raises different issues from liquid chromatography mobile phases, especially due to decompression of carbon dioxide. It is also shown that the frontiers between SFC and HPLC are fading, as switching from one method to the other, even within the course of a single analysis, is facilitated my modern instruments. The present review is not intended to be exhaustive but rather giving a snapshot of recent trends in supercritical fluid chromatography, based on the observation of about 500 papers published in English-written peer-reviewed journals from 2014 to 2018. Graphical abstract ᅟ.

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Simultaneous determination of inorganic anions and cations by supercritical fluid chromatography using evaporative light scattering detection

Cited by 18 publications

References 39 publications

Quantitative nuclear magnetic resonance of chloride by an accurate internal standard approach

Quantitative nuclear magnetic resonance of chloride by an accurate internal standard approach

Green Chromatography and Related Techniques

Current trends in supercritical fluid chromatography

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