Asymmetries in initiation of aiming movements in schizophrenia

Lisi, Giulia; Nico, Daniele; Ribolsi, Michele; Niolu, Cinzia; Lacquaniti, Francesco; Siracusano, Alberto; Daprati, Elena

doi:10.1016/j.neuropsychologia.2017.12.030

Cited by 3 publications

(3 citation statements)

References 79 publications

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“…Sensorimotor abnormalities are inherent symptoms of schizophrenia and include coordination problems, neurological soft signs, psychomotor retardation, dyskinesias, catatonia, and Parkinsonism [1][2][3]. These abnormalities often precede a first psychotic episode and can therefore serve as prodromal warning signs.…”

Section: Introductionmentioning

confidence: 99%

Impaired Sensorimotor Adaption in Schizophrenia in Comparison to Age-Matched and Elderly Controls

et al. 2021

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Background: The “cognitive dysmetria hypothesis” of schizophrenia proposes a disrupted communication between the cerebellum and cerebral cortex, resulting in sensorimotor and cognitive symptoms. Sensorimotor adaptation relies strongly on the function of the cerebellum. Objectives: This study investigated whether sensorimotor adaptation is reduced in schizophrenia compared with age-matched and elderly healthy controls. Methods: Twenty-nine stably treated patients with schizophrenia, 30 age-matched, and 30 elderly controls were tested in three motor adaptation tasks in which visual movement feedback was unexpectedly altered. In the “rotation adaptation task” the perturbation consisted of a rotation (30° clockwise), in the “gain adaptation task” the extent of the movement feedback was reduced (by a factor of 0.7) and in the “vertical reversal task,” up- and downward pen movements were reversed by 180°. Results: Patients with schizophrenia adapted to the perturbations, but their movement times and errors were substantially larger than controls. Unexpectedly, the magnitude of adaptation was significantly smaller in schizophrenia than elderly participants. The impairment already occurred during the first adaptation trials, pointing to a decline in explicit strategy use. Additionally, post-adaptation aftereffects provided strong evidence for impaired implicit adaptation learning. Both negative and positive schizophrenia symptom severities were correlated with indices of the amount of adaptation and its aftereffects. Conclusions: Both explicit and implicit components of sensorimotor adaptation learning were reduced in patients with schizophrenia, adding to the evidence for a role of the cerebellum in the pathophysiology of schizophrenia. Elderly individuals outperformed schizophrenia patients in the adaptation learning tasks.

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Section: Introductionmentioning

confidence: 99%

Impaired Sensorimotor Adaption in Schizophrenia in Comparison to Age-Matched and Elderly Controls

et al. 2021

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“…Schizophrenia is also characterized by various motor symptom clusters 4 , including neurological soft signs (subtle deficits in sensory integration, motor coordination, and sequencing of complex motor acts), abnormal involuntary movements (such as dyskinesias), psychomotor slowing (reduced movement speed in planning, initiation and execution of fine motor tasks), catatonia (such as immobility/stupor, mutism, catalepsy, grimacing, echopraxia, stereotypy, mannerisms) and extrapyramidal symptoms (EPS, such as Parkinsonism, akathisia, acute dystonic reactions and tardive dyskinesia). [5][6][7] Some clusters, such as psychomotor poverty and neurological soft signs, seem to co-exist independently from each other 8 .…”

Section: Motor Symptoms In Schizophreniamentioning

confidence: 99%

“…Sensorimotor abnormalities are inherent symptoms of schizophrenia and include coordination problems, neurological soft signs, psychomotor retardation, dyskinesias, catatonia, and Parkinsonism [5][6][7] . These abnormalities often precede a first psychotic episode and can therefore serve as prodromal warning signs.…”

Section: Introductionmentioning

confidence: 99%

Hitting the target : exploring motor learning and performance in schizophrenia and ageing

Cornelis

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Upper extremity asymmetry due to nerve injuries or central neurologic conditions: a scoping review

Bhat,

Shin,

Kaufman

2023

J NeuroEngineering Rehabil

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Background Peripheral nerve injuries and central neurologic conditions can result in extensive disabilities. In cases with unilateral impairment, assessing the asymmetry between the upper extremity has been used to assess outcomes of treatment and severity of injury. A wide variety of validated and novel tests and sensors have been utilized to determine the upper extremity asymmetry. The purpose of this article is to review the literature and define the current state of the art for describing upper extremity asymmetry in patients with peripheral nerve injuries or central neurologic conditions. Method An electronic literature search of PubMed, Scopus, Web of Science, OVID was performed for publications between 2000 to 2022. Eligibility criteria were subjects with neurological conditions/injuries who were analyzed for dissimilarities in use between the upper extremities. Data related to study population, target condition/injury, types of tests performed, sensors used, real-world data collection, outcome measures of interest, and results of the study were extracted. Sackett’s Level of Evidence was used to judge the quality of the articles. Results Of the 7281 unique articles, 112 articles met the inclusion criteria for the review. Eight target conditions/injuries were identified (Brachial Plexus Injury, Cerebral Palsy, Multiple Sclerosis, Parkinson’s Disease, Peripheral Nerve Injury, Spinal Cord Injury, Schizophrenia, and stroke). The tests performed were classified into thirteen categories based on the nature of the test and data collected. The general results related to upper extremity asymmetry were listed for all the reviewed articles. Stroke was the most studied condition, followed by cerebral palsy, with kinematics and strength measurement tests being the most frequently used tests. Studies with a level of evidence level II and III increased between 2000 and 2021. The use of real-world evidence-based data, and objective data collection tests also increased in the same period. Conclusion Adequately powered randomized controlled trials should be used to study upper extremity asymmetry. Neurological conditions other than stroke should be studied further. Upper extremity asymmetry should be measured using objective outcome measures like motion tracking and activity monitoring in the patient’s daily living environment.

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Asymmetries in initiation of aiming movements in schizophrenia

Cited by 3 publications

References 79 publications

Impaired Sensorimotor Adaption in Schizophrenia in Comparison to Age-Matched and Elderly Controls

Impaired Sensorimotor Adaption in Schizophrenia in Comparison to Age-Matched and Elderly Controls

Hitting the target : exploring motor learning and performance in schizophrenia and ageing

Upper extremity asymmetry due to nerve injuries or central neurologic conditions: a scoping review

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