Redox-Responsive Manganese Dioxide Nanoparticles for Enhanced MR Imaging and Radiotherapy of Lung Cancer

Cho, Mi Hyeon; Choi, Eun-Chang; Kim, Sehee; Goh, Sung‐Ho; Choi, Yongdoo

doi:10.3389/fchem.2017.00109

Cited by 55 publications

(23 citation statements)

References 30 publications

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“…Radiation therapy produces ROS (•OH) by the radiolysis of water molecules in the tumor, which can cause cancer cell death. However, high concentrations of intracellular GSH neutralize intracellular ROS to protect the cell, limiting the effects of radiotherapy (Cho et al, 2017 ). Reportedly, MnO 2 nanoparticles oxidize GSH to glutathione disulfide (GSSG), reducing GSH levels in the tumor, promoting radiotherapy effects, and enhancing ROS activity against cancer cells (Cho et al, 2017 ).…”

Section: Internal Stimuli-responsive Metallic Nanotherapeuticsmentioning

confidence: 99%

“…However, high concentrations of intracellular GSH neutralize intracellular ROS to protect the cell, limiting the effects of radiotherapy (Cho et al, 2017 ). Reportedly, MnO 2 nanoparticles oxidize GSH to glutathione disulfide (GSSG), reducing GSH levels in the tumor, promoting radiotherapy effects, and enhancing ROS activity against cancer cells (Cho et al, 2017 ). Yang et al developed attractive hollow MnO 2 nanoparticles for TME-specific on-demand drug delivery and imaging.…”

Section: Internal Stimuli-responsive Metallic Nanotherapeuticsmentioning

confidence: 99%

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External and Internal Stimuli-Responsive Metallic Nanotherapeutics for Enhanced Anticancer Therapy

Mohapatra

Uthaman

Park

2021

Front. Mol. Biosci.

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Therapeutic, diagnostic, and imaging approaches based on nanotechnology offer distinct advantages in cancer treatment. Various nanotherapeutics have been presented as potential alternatives to traditional anticancer therapies such as chemotherapy, radiotherapy, and surgical intervention. Notably, the advantage of nanotherapeutics is mainly attributable to their accumulation and targeting ability toward cancer cells, multiple drug-carrying abilities, combined therapies, and imaging approaches. To date, numerous nanoparticle formulations have been developed for anticancer therapy and among them, metallic nanotherapeutics reportedly demonstrate promising cancer therapeutic and diagnostic efficiencies owing to their dense surface functionalization ability, uniform size distribution, and shape-dependent optical responses, easy and cost-effective synthesis procedure, and multiple anti-cancer effects. Metallic nanotherapeutics can remodel the tumor microenvironment by changing unfavorable therapeutic conditions into therapeutically accessible ones with the help of different stimuli, including light, heat, ultrasound, an alternative magnetic field, redox, and reactive oxygen species. The combination of metallic nanotherapeutics with both external and internal stimuli can be used to trigger the on-demand release of therapeutic molecules, augmenting the therapeutic efficacies of anticancer therapies such as photothermal therapy, photodynamic therapy, magnetic hyperthermia, sonodynamic therapy, chemodynamic therapy, and immunotherapy. In this review, we have summarized the role of different metallic nanotherapeutics in anti-cancer therapy, as well as their combinational effects with multiple stimuli for enhanced anticancer therapy.

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Section: Internal Stimuli-responsive Metallic Nanotherapeuticsmentioning

confidence: 99%

Section: Internal Stimuli-responsive Metallic Nanotherapeuticsmentioning

confidence: 99%

External and Internal Stimuli-Responsive Metallic Nanotherapeutics for Enhanced Anticancer Therapy

Mohapatra

Uthaman

Park

2021

Front. Mol. Biosci.

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“…32 Fortunately, MnO 2 possesses excellent catalytic properties to decompose H 2 O 2 into O 2 and H 2 O under acidic conditions; therefore, it has been utilized as a vital component of various nanoplatforms intended to reoxygenate hypoxic tumors and improve therapeutic efficacy. [33][34][35][36] As a remarkable example, Fan et al achieved simultaneous stimuli-responsive imaging and O 2 -upregulating therapy on a single nanoplatform. In brief, they successfully anchored upconversion NPs (UCNPs) to two-dimensional MnO 2 nanosheets by a facile nonchemical method.…”

Section: H 2 O 2 Catalyst-based Nanoplatforms For Reoxygenationmentioning

confidence: 99%

Advanced nanomaterials targeting hypoxia to enhance radiotherapy

Li¹,

Shang²,

Li³

et al. 2018

IJN

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Hypoxia within solid tumors is often responsible for the failure of radiotherapy. The development of hypoxia-targeting nanomaterials – aimed at enhancing the effect of radiotherapy by electrical or heat effects and at modulating hypoxia in the tumor microenvironment – is a promising strategy to address this issue. We provide an overview of recently developed advanced materials that potentiate radiotherapy. First, we summarize novel materials for oxygen delivery or production to modify the tumor microenvironment, thus improving the effects of ionizing radiation. Second, we present new approaches for the design of high-Z element–based multifunctional nanoplatforms to enhance radiotherapy. Third, novel drug delivery systems for hypoxic regions and hypoxia-inducible factor-1–targeted therapies are discussed. Fourth, we establish the effectiveness of X-ray- or near-infrared–responsive nanoparticles for selectively triggering therapeutic effects under hypoxic conditions. Finally, this review emphasizes the importance of research in the field of nanomedicine focused on tumor hypoxia to improve clinical outcomes.

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“…There are numerous examples of natural nanomaterials formed this way, such as the CaSO 4 and silicate particles in spring water [ 16 ]. Indeed, such inorganic particles recently have inspired colleagues to synthesize a wide range of similar particles based on naturally occurring materials, such as—refined—nanoparticles of Fe 3 O 4 and MnO 2 [ 56 , 57 ]. Concurrently, Nature, in cahoots with human activities, often unwillingly generates such “nanosized” particles from bulk materials, as the hot issue of microplastic in our oceans, fish and food highlights [ 58 , 59 ].…”

Section: Natural But Not Biological: the Free Flow Of Inorganic Namentioning

confidence: 99%

Natural Nanoparticles: A Particular Matter Inspired by Nature

et al. 2017

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During the last couple of decades, the rapidly advancing field of nanotechnology has produced a wide palette of nanomaterials, most of which are considered as “synthetic” and, among the wider public, are often met with a certain suspicion. Despite the technological sophistication behind many of these materials, “nano” does not always equate with “artificial”. Indeed, nature itself is an excellent nanotechnologist. It provides us with a range of fine particles, from inorganic ash, soot, sulfur and mineral particles found in the air or in wells, to sulfur and selenium nanoparticles produced by many bacteria and yeasts. These nanomaterials are entirely natural, and, not surprisingly, there is a growing interest in the development of natural nanoproducts, for instance in the emerging fields of phyto- and phyco-nanotechnology. This review will highlight some of the most recent—and sometimes unexpected—advances in this exciting and diverse field of research and development. Naturally occurring nanomaterials, artificially produced nanomaterials of natural products as well as naturally occurring or produced nanomaterials of natural products all show their own, particular chemical and physical properties, biological activities and promise for applications, especially in the fields of medicine, nutrition, cosmetics and agriculture. In the future, such natural nanoparticles will not only stimulate research and add a greener outlook to a traditionally high-tech field, they will also provide solutions—pardon—suspensions for a range of problems. Here, we may anticipate specific biogenic factories, valuable new materials based on waste, the effective removal of contaminants as part of nano-bioremediation, and the conversion of poorly soluble substances and materials to biologically available forms for practical uses.

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Redox-Responsive Manganese Dioxide Nanoparticles for Enhanced MR Imaging and Radiotherapy of Lung Cancer

Cited by 55 publications

References 30 publications

External and Internal Stimuli-Responsive Metallic Nanotherapeutics for Enhanced Anticancer Therapy

External and Internal Stimuli-Responsive Metallic Nanotherapeutics for Enhanced Anticancer Therapy

Advanced nanomaterials targeting hypoxia to enhance radiotherapy

Natural Nanoparticles: A Particular Matter Inspired by Nature

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