Biotransformation of 20(R)-panaxatriol by the fungus Aspergillus flavus Link AS 3.3950

Abstract

Microbial transformation of 20(R)-panaxatriol by the fungus Aspergillus flavus Link AS 3.3950 was performed. Four new (1-4), along with two previously reported metabolites (5 and 6), were obtained. Their chemical structures were elucidated on the basis of extensive spectroscopic analyses. Furthermore, the inhibitory effects of those compounds on K562/ADR, Du-145, Hela, MCF-7 and HepG2 cell lines were evaluated by MTT assay. Among them, compound 15β-hydroxy-20(R)-panaxatriol (4) exhibited selective inhibitory effects on human leukaemic progenitor cells K562/ADR through arresting cell cycle, which was associated with obvious decrease of cyclin B1, cyclin D1 and cyclin-dependent kinase (CDK) 1/2/4/6 protein expression.

Ginsengenin derivatives synthesized from 20(R)-panaxotriol: Synthesis, characterization, and antitumor activity targeting HIF-1 pathway

“…evaluated the inhibitory effects of panaxotriol derivatives on K562/ADR, Du-145, HeLa, MCF-7, and HepG2 cell lines. It has been proven that panaxotriol can selectively inhibit the human leukemia progenitor K562/ADR by arresting the cell cycle [ 25 ].

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