Unilateral repetitive transcranial magnetic stimulation differentially affects younger and older adults completing a verbal working memory task

Shields, Jessica; Mock, Jeffrey R.; Devier, Deidre; Foundas, Anne L.

doi:10.1016/j.jns.2017.10.021

Cited by 11 publications

(14 citation statements)

References 41 publications

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“…From the behavioral perspective, a direct comparison of TBS effects on WM over the left and right DLPFC is lacking in the current literature. Traditional TMS studies have found that verbal WM appears to be modified by left but not right DLPFC stimulation 33 , 34 . Others have reported rTMS to effectively modulate WM both over the left and the right DLPFC 3 , 35 – 38 .…”

Section: Introductionmentioning

confidence: 99%

Continuous theta-burst stimulation over the dorsolateral prefrontal cortex inhibits improvement on a working memory task

Vékony

Németh

Holczer

et al. 2018

Sci Rep

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Theta-burst stimulation (TBS) over the dorsolateral prefrontal cortex (DLPFC) may be more effective for modulating cortical excitability compared to standard repetitive transcranial magnetic stimulation. However, the impact of intermittent (iTBS) and continuous TBS (cTBS) on working memory (WM) is poorly studied. The aim of our study was to compare the effects of iTBS and cTBS on WM over the left and right DLPFC. iTBS, cTBS or sham stimulation was administered over the right and left hemisphere of fifty-one healthy human subjects. WM was assessed before and after TBS using the 1-back, 2-back, and 3-back tasks. We found classical practice effects in the iTBS and the sham group: WM performance improved following stimulation as measured by the discriminability index. However, this effect could not be observed in the cTBS group. We did not find any hemisphere-dependent effects, suggesting that the practice effect is not lateralized, and TBS affects WM performance in a comparable manner if administered either over the left or the right hemisphere. We propose that our findings represent a useful addition to the literature of TBS-induced effects on WM. Moreover, these results indicate the possibility of clarifying processes underlying WM performance changes by using non-invasive brain stimulation.

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Section: Introductionmentioning

confidence: 99%

Continuous theta-burst stimulation over the dorsolateral prefrontal cortex inhibits improvement on a working memory task

Vékony

Németh

Holczer

et al. 2018

Sci Rep

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“…Consistent with our results, significant effects of HF rTMS protocols without a cognitive load on WM performance have been obtained in several studies. Different TMS protocols were used, including HF [46] and LF rTMS [19], as well as cTBS [21,47] and iTBS [20,48]. Improvement of WM accuracy and reaction times after HF rTMS over DLPFC was also confirmed in a meta-analysis; however, the inhomogeneity of the analyzed studies remains an important limitation [25].…”

Section: Discussionmentioning

confidence: 95%

“…The investigation of rTMS offline-effects on cognitive functions is very important in the context of its use as a therapeutic technique. TMS over the left DLPFC has already been used both for investigation of its causal role in WM processes in healthy volunteers [18][19][20][21][22] and as a method of WM improvement in patients with WM impairments [23,24]. In a meta-analysis of studies using high frequency (HF) rTMS over the left DLPFC, a significant improvement of WM accuracy and reaction times measured by n-back task has been confirmed [25].…”

Section: Introductionmentioning

confidence: 99%

Combining HF rTMS over the Left DLPFC with Concurrent Cognitive Activity for the Offline Modulation of Working Memory in Healthy Volunteers: A Proof-of-Concept Study

et al. 2020

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It has been proposed that the effectiveness of non-invasive brain stimulation (NIBS) as a cognitive enhancement technique may be enhanced by combining the stimulation with concurrent cognitive activity. However, the benefits of such a combination in comparison to protocols without ongoing cognitive activity have not yet been studied. In the present study, we investigate the effects of fMRI-guided high-frequency repetitive transcranial magnetic stimulation (HF rTMS) over the left dorsolateral prefrontal cortex (DLPFC) on working memory (WM) in healthy volunteers, using an n-back task with spatial and verbal stimuli and a spatial span task. In two combined protocols (TMS + WM + (maintenance) and TMS + WM + (rest)) trains of stimuli were applied in the maintenance and rest periods of the modified Sternberg task, respectively. We compared them to HF rTMS without a cognitive load (TMS + WM −) and control stimulation (TMS − WM + (maintenance)). No serious adverse effects appeared in this study. Among all protocols, significant effects on WM were shown only for the TMS + WM − with oppositely directed influences of this protocol on storage and manipulation in spatial WM. Moreover, there was a significant difference between the effects of TMS + WM − and TMS + WM + (maintenance), suggesting that simultaneous cognitive activity does not necessarily lead to an increase in TMS effects.

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“…Estudos funcionais de neuroimagem (Shields et al, 2018) demonstraram que a lateralização da atividade no CPFDL diminui com o envelhecimento. A partir desta evidência, um estudo controlado por placebo utilizou a EMTr no CPFDL para testar a relação da lateralidade e da idade no desempenho de uma tarefa de memória de trabalho verbal, comparando um grupo de indivíduos mais jovens (n=36) com um grupo de indivíduos idosos (n=35) que receberam 1Hz de EMTr no CPFDL esquerdo ou direito e foram avaliados pré e pós-estimulação através da tarefa "n-back task".…”

Section: Memória De Trabalho E Emtunclassified

“…Os indivíduos idosos não apresentaram melhora da memória de trabalho em nenhuma das condições de estimulação. Os resultados demonstraram que as mudanças na lateralidade pré-frontal são evidentes com o aumento da idade, sendo que a estimulação esquerda afeta positivamente a precisão da memória de trabalho dos adultos mais jovens, enquanto os adultos mais velhos não são afetados pela estimulação (Shields et al, 2018).…”

Section: Memória De Trabalho E Emtunclassified

Avaliação da eficácia clínica-cognitiva e segurançaa da estimulação magnética transcraniana com bobina h1 no tratamento de episódios de depressão bipolar

Myczkowski¹

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Unilateral repetitive transcranial magnetic stimulation differentially affects younger and older adults completing a verbal working memory task

Cited by 11 publications

References 41 publications

Continuous theta-burst stimulation over the dorsolateral prefrontal cortex inhibits improvement on a working memory task

Continuous theta-burst stimulation over the dorsolateral prefrontal cortex inhibits improvement on a working memory task

Combining HF rTMS over the Left DLPFC with Concurrent Cognitive Activity for the Offline Modulation of Working Memory in Healthy Volunteers: A Proof-of-Concept Study

Avaliação da eficácia clínica-cognitiva e segurançaa da estimulação magnética transcraniana com bobina h1 no tratamento de episódios de depressão bipolar

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