Bayesian informed evidence against modulation of androstadienone-effects by genotypic receptor variants and participant sex: A study assessing Stroop interference control, mood and olfaction

Hornung, Jonas; Noack, Hannes; Thomas, Mara; Farger, Gisbert; Nieratschker, Vanessa; Freiherr, Jessica; Derntl, Birgit

doi:10.1016/j.yhbeh.2017.12.003

Cited by 9 publications

(4 citation statements)

References 43 publications

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“…In the next study 157 hypothalamic fMRI responses to a high dose of AND, delivered to the nares using an olfactometer, were compared in adolescent children diagnosed with gender dysphoria and in normal children. 159 This result corroborates the earlier result 155 in which adult male to female transgender people showed a stronger hypothalamic PET response to AND than control male subjects.…”

Section: Brain Regions Activated By Putative Human Pheromonessupporting

confidence: 90%

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Sex differences in main olfactory system pathways involved in psychosexual function

Cherry

Baum

2019

Genes Brain and Behavior

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We summarize literature from animal and human studies assessing sex differences in the ability of the main olfactory system to detect and process sex-specific olfactory signals ("pheromones") that control the expression of psychosexual functions in males and females. A case is made in non primate mammals for an obligatory role of pheromonal signaling via the main olfactory system (in addition to the vomeronasalaccessory olfactory system) in mate recognition and sexual arousal, with male-specific as well as female-specific pheromones subserving these functions in the opposite sex.Although the case for an obligatory role of pheromones in mate recognition and mating among old world primates, including humans, is weaker, we review the current literature assessing the role of putative human pheromones (eg, AND, EST, "copulin"), detected by the main olfactory system, in promoting mate choice and mating in men and women. Based on animal studies, we hypothesize that sexually dimorphic effects of putative human pheromones are mediated via main olfactory inputs to the medial amygdala which, in turn, transmits olfactory information to sites in the hypothalamus that regulate reproduction.K E Y W O R D S accessory olfactory system, chemosignal, human, main olfactory bulb, main olfactory epithelium, main olfactory system, medial amygdala, mouse, pheromone, sex difference, sexual behavior

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Section: Brain Regions Activated By Putative Human Pheromonessupporting

confidence: 90%

“…158 Insofar as AND is detected by the MOE odorant receptor, OR7D4, it is surprising that human subjects of both sexes showed enhanced emotional responses to visual stimuli that were equivalent in individuals with genotypic variations in expression of the OR7D4 AND receptor. 159…”

Section: Brain Regions Activated By Putative Human Pheromonesmentioning

confidence: 99%

Sex differences in main olfactory system pathways involved in psychosexual function

Cherry

Baum

2019

Genes Brain and Behavior

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“…Furthermore, a visual priming study using neutral faces reported no influence of androstadienone on attentional prioritization of social over nonsocial stimuli (see study 3 in Hummer and McClintock, 2009). Besides, several studies using the modified emotional Stroop task (e.g., faces with fearful and happy expressions presented with the words "happy" or "fear" written across them, Etkin et al, 2006) either found small effects on reduction of error rates, but not reaction times (Hornung et al, 2018b), reported findings limited to angry faces and to male participants (Hornung et al, 2017), or failed to find effects of androstadienone (Hornung et al, 2018a).…”

Section: General Social Cognitionmentioning

confidence: 99%

Olfaction in the Multisensory Processing of Faces: A Narrative Review of the Influence of Human Body Odors

et al. 2021

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A recent body of research has emerged regarding the interactions between olfaction and other sensory channels to process social information. The current review examines the influence of body odors on face perception, a core component of human social cognition. First, we review studies reporting how body odors interact with the perception of invariant facial information (i.e., identity, sex, attractiveness, trustworthiness, and dominance). Although we mainly focus on the influence of body odors based on axillary odor, we also review findings about specific steroids present in axillary sweat (i.e., androstenone, androstenol, androstadienone, and estratetraenol). We next survey the literature showing body odor influences on the perception of transient face properties, notably in discussing the role of body odors in facilitating or hindering the perception of emotional facial expression, in relation to competing frameworks of emotions. Finally, we discuss the developmental origins of these olfaction-to-vision influences, as an emerging literature indicates that odor cues strongly influence face perception in infants. Body odors with a high social relevance such as the odor emanating from the mother have a widespread influence on various aspects of face perception in infancy, including categorization of faces among other objects, face scanning behavior, or facial expression perception. We conclude by suggesting that the weight of olfaction might be especially strong in infancy, shaping social perception, especially in slow-maturing senses such as vision, and that this early tutoring function of olfaction spans all developmental stages to disambiguate a complex social environment by conveying key information for social interactions until adulthood.

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“…Thus, genetic variation in OR7D4 may affect food preferences. Meanwhile, in a recent study of Hornung et al (2018) homozygous carriers of RT allele did not rate the related steroid androstedienone as more intense and unpleasant than heterozygous carriers nor did sensitivity towards the odorant differ between these groups (n=72). In parallel to the described above, Menashe and colleagues studied genetic determinants of sensitivity to isovaleric acid (Menashe et al, 2007).…”

Section: Specific Anosmia In Humans and Animals: Environmental And Gementioning

confidence: 91%

Specific anosmia in humans and animals: Environmental and genetic influences

Klyuchnikova¹,

Voznessenskaya²

2019

Ukr J Ecol

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Olfaction plays a very important role across the lifespan of most mammalian species, including humans. Being the oldest, chemical communication is one of the least understood forms of communication due in part to the difficulty of detecting and measuring the chemicals in a sample. The ability to detect chemicals in the environment serves many functions. Individuals with specific anosmia, or “odor blindness”, have significantly increased olfactory thresholds to particular odorants though they show normal general olfactory acuity. Hereby we review research on specific anosmia in humans, factors that may affect individual variation in olfaction as well as animal models of specific anosmia. Variability in sensitivity to odorants is influenced by genotype, age, gender, individual olfactory experience and environmental cues. Large data pile from human and animal studies suggests that not all factors are determined yet. The possibility of induction of olfactory sensitivity to biologically relevant chemical cues is discussed. Olfactory plasticity determines the adaptability of the species to the environment. Mechanisms that underlie the induction of sensitivity to the odorants still to be elucidated.

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Bayesian informed evidence against modulation of androstadienone-effects by genotypic receptor variants and participant sex: A study assessing Stroop interference control, mood and olfaction

Cited by 9 publications

References 43 publications

Sex differences in main olfactory system pathways involved in psychosexual function

Sex differences in main olfactory system pathways involved in psychosexual function

Olfaction in the Multisensory Processing of Faces: A Narrative Review of the Influence of Human Body Odors

Specific anosmia in humans and animals: Environmental and genetic influences

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