Associations Between Dietary Patterns and Longitudinal Quality of Life Changes in Colorectal Cancer Patients: The ColoCare Study

Abstract

Quality of life (QoL) is an important clinical outcome in cancer patients. We investigated associations between dietary patterns and QoL changes in colorectal cancer (CRC) patients. The study included 192 CRC patients with available EORTC QLQ-C30 data before and 12 months post-surgery and food frequency questionnaire data at 12 months post-surgery. Principal component analysis was used to identify dietary patterns. Multivariate regression models assessed associations between dietary patterns and QoL changes over time. We identified four major dietary patterns: “Western” dietary pattern characterized by high consumption of potatoes, red and processed meat, poultry, and cakes, “fruit&vegetable” pattern: high intake of vegetables, fruits, vegetable oils, and soy products, “bread&butter” pattern: high intake of bread, butter and margarine, and “high-carb” pattern: high consumption of pasta, grains, nonalcoholic beverages, sauces and condiments. Patients following a “Western” diet had lower chances to improve in physical functioning (OR = 0.45 [0.21–0.99]), constipation (OR = 0.30 [0.13–0.72]) and diarrhea (OR: 0.44 [0.20–0.98]) over time. Patients following a “fruit&vegetable” diet showed improving diarrhea scores (OR: 2.52 [1.21–5.34]. A “Western” dietary pattern after surgery is inversely associated with QoL in CRC patients, whereas a diet rich in fruits and vegetables may be beneficial for patients’ QoL over time.

One-carbon metabolites, B vitamins and associations with systemic inflammation and angiogenesis biomarkers among colorectal cancer patients: results from the ColoCare Study

“…This is a cross-sectional analysis of baseline data from the ColoCare Study, a multicentre, international prospective cohort initiated at the Fred Hutchinson Cancer Research Center (Seattle, WA, USA), described in detail in prior publications (21)(22)(23) . ColoCare recruits newly diagnosed CRC patients prior to surgery, with the goal to investigate predictors of cancer recurrence, survival, treatment toxicities and health-related QoL.…”

Inflammation‐ and angiogenesis‐related biomarkers are correlated with cancer‐related fatigue in colorectal cancer patients: Results from the ColoCare Study

“…Fatigue scores were measured based on the European Organization for Research and Treatment of Cancer (EORTC) QLQ‐C30 questionnaire at baseline and 6‐, and 12‐month follow‐up (Gigic et al, ). The EORTC QLQ‐C30 is a validated health‐related quality of life (HRQOL) instrument, and it includes a three‐item fatigue subscale (Knobel et al, ).…”

“…Fatigue scores were measured based on the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire at baseline and 6-, and 12-month follow-up (Gigic et al, 2018).…”

Assoziationen von Tumorpatienten und deren Behandelnden zu den Themen Ernährung und Appetit

“…Ernährung und Nahrung tragen nicht nur in hohem Maße zu Lebensqualität bei, sondern zählen zu den Grundbedürfnissen des Menschen. Sie spielen auch in fortgeschrittenen Krankheitsstadien eine erhebliche Rolle, besonders als Beitrag zum Erhalt der Lebensqualität von Tumorpatienten [2]. Sie tragen als Lebensstilfaktoren direkt zur Primär-aber auch Tertiärprävention beispielsweise beim Kolonkarzinom bei [3].…”