High Antimicrobial Activity of Metal–Organic Framework-Templated Porphyrin Polymer Thin Films

Abstract

Development of surface coatings with high antimicrobial activity is urgently required to fight bacteria and other microorganisms on technical and hygiene relevant surfaces. Control over structure and topology of the surface coatings, combined with the ability to include functional molecules within the structure, is crucial for optimizing their performance. Herein, we describe a novel strategy to synthesize structurally well-defined porphyrin polymer thin films via a template approach. In this approach, bisazido-functionalized porphyrin molecules are preorganized within a metal-organic framework (MOF) structure. Afterward, porphyrin units within the MOF are covalently connected via a secondary linker. Removal of the metal ions of the MOF results in water-stable porphyrin polymer thin films that demonstrate high antibacterial activity against pathogens via visible-light-promoted generation of reactive oxygen species. In addition, this approach offers the inherent possibility to incorporate guest molecules within the structures, to functionalize the surface with biomolecules, and to create hierarchically structured materials.

Metal–Organic Frameworks for Biomedical Applications

“…MOF‐based antimicrobial nanoplatforms generally contain one or more of the following features: 1) metal nodes in MOFs (such as Ag, Cu, Ni, Zn, etc.) exhibiting antibacterial activity that could undergo sustained release during the degradation of MOFs to achieve high effective antibacterial effect,56 2) the excellent containment of antimicrobial molecules based on the high surface areas and adjustable pore sizes of MOFs,57 3) the organic linkers used to build the MOF scaffolds, such as porphyrin derivatives, offering a potential to combine PDT for bacterial infections,58 4) flexible post‐modification methods that promote the further functionalization of MOFs 59. In this part, we will introduce the application progress of MOF‐based nanoplatforms in antibacterial field.…”

A novel synthesis of new antibacterial nanostructures based on Zn-MOF compound: design, characterization and a high performance application

“…Zhou and coworkers incorporated porphyrin systems into a surfaceanchored MOF converted into a metal-free and extremely waterresistant antimicrobial coating [26].…”

A biomimetic cellulose‐based composite material that incorporates the antimicrobial metal‐organic framework HKUST‐1

“…There has been much interest reported in the literature on Metal‐Organic Frameworks (MOFs) in recent years for a wide variety of applications, including gas sequestration, photochemical applications, catalysis, and waste remediation, due to the unique porous nature and tunability MOFs provide . Although often employed as a bulk material, the incorporation of MOFs into substrates is becoming a popular area of materials science, particularly in regards to sorption technologies.…”