Periconception Exposure to Air Pollution and Risk of Congenital Malformations

Ren, Shan; Haynes, Erin N.; Hall, Eric S.; Hossain, Monir; Chen, Aimin; Muglia, Louis J.; Lu, Long; DeFranco, Emily

doi:10.1016/j.jpeds.2017.09.076

Cited by 39 publications

(39 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Within certain populations (e.g., undocumented individuals), residential data may be incorrect. These weaknesses, however, are inherent in all retrospective studies relying on residential data [11,49,55,58,59,60,61,62,63,64,65,66]. Finally, this report does not address the mechanism of action of the HMHAPs.…”

Section: Discussionmentioning

confidence: 93%

“…As the birth prevalence of hypospadias increases across the world [4,5,6,7,8,9,10], research into the association between pollutant exposure and hypospadias has defined a critical exposure period as the early first trimester of pregnancy [11]. Pollutants which interfere with MET during genitourinary development or hormonal cascades may play a role in hypospadias etiology.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hypospadias Risk from Maternal Residential Exposure to Heavy Metal Hazardous Air Pollutants

White

Kovar

Chambers

et al. 2019

IJERPH

View full text Add to dashboard Cite

Objective: Investigate whether residential prenatal exposure to heavy metal hazardous air pollutants (HMHAPs) is associated with an increased risk of hypospadias. Methods: Data on non-syndromic hypospadias cases (n = 8981) and control patients delivered in Texas were obtained from the Texas Birth Defects Registry and matched 1:10 by birth year. Average exposure concentrations of HMHAPs were obtained from the 2005 U.S. Environmental Protection Agency National-Scale Air Toxics Assessment and categorized into quintiles. Odds ratios and 95% confidence intervals were estimated. STROBE reporting guidelines were followed. Results: We observed associations between hypospadias and prenatal HMHAP exposure. Manganese demonstrated significant increased risk of hypospadias at the medium, medium-high and high exposure quintiles; lead in the medium-high and high exposure quintiles. Cadmium, mercury and nickel demonstrated a significant inverted “U-shaped” association for exposures with significant associations in the medium and medium-high quintiles but not in the medium-low and high quintiles. Arsenic and chromium demonstrated a significant bivalent association for risk of hypospadias in a lower quintile as well as a higher quintile with non-significant intermediate quintiles. Conclusions: Using data from one of the world’s largest active surveillance birth defects registries, we identified significant associations between hypospadias and HMHAP exposures. These results should be used in counseling for maternal demographic risk factors as well as avoidance of heavy metals and their sources.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Hypospadias Risk from Maternal Residential Exposure to Heavy Metal Hazardous Air Pollutants

White

Kovar

Chambers

et al. 2019

IJERPH

View full text Add to dashboard Cite

show abstract

“…Although levels are decreasing, they remain high enough that we continue to discover associations between relatively low exposure and human health. Exposure to air pollution has been linked to a host of health conditions including adverse pregnancy outcomes such as pre-eclampsia (Olsson et al, 2013;Wu et al, 2009), gestational hypertension (Van Den Hooven et al, 2011;Vinikoor-Imler et al, 2012), infant death (Defranco et al, 2015;Glinianaia et al, 2004), low birth weight (Dadvand et al, 2013), infant congenital malformations (Ren et al, 2017), preterm birth (Defranco et al, 2016), and infants born small-for-gestational-age (SGA) (Hyder et al, 2014;Parker et al, 2005). A joint consensus statement by the International Societies of Pediatric Endocrinology and the Growth Hormone Research Society discusses the negative outcomes which babies born SGA face over their lifespans including decreased growth, cognitive impairment, endocrine abnormalities, insulin resistance, and cardiovascular disease (Clayton et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Trimester specific PM2.5 exposure and fetal growth in Ohio, 2007–2010

Percy

DeFranco

et al. 2019

Environmental Research

Self Cite

View full text Add to dashboard Cite

Background: Exposure to particulate matter, particularly with aerodynamic diameter <2.5 μm (PM 2.5), may increase inflammation and oxidative stress in pregnant women and affect fetal growth. We examined trimester specific PM 2.5 exposure levels and small for gestational age (SGA) using the statewide birth registry of Ohio from 2007 to 2010. Methods: Exposure to PM 2.5 in each trimester and for each gestational week was determined using data from 57 Environmental Protection Agency network monitoring stations across the state of Ohio. We restricted the data to 224,921 singleton live births, with a gestational age of 20-42 weeks, no genetic disorders or congenital abnormalities, and who had home addresses within a 10 km radius of any PM 2.5 monitoring station. We estimated odds ratios of SGA using Generalized Linear Models (GLMs) and Distributed Lag Models (DLMs), and adjustment for maternal age, race, education, parity, body mass index, insurance type, tobacco use, prenatal care initiation, birth year, season of birth, and sex of the baby. Results: Mean PM 2.5 levels during the entire pregnancy were 13.03 μg/m 3 with a standard deviation of 1.57 μg/m 3. Covariates adjusted odds ratios and 95% confidence intervals of a 10 μg/m 3 increase in PM 2.5 levels with a 10 km buffer radius for SGA and trimesters modeled separately were 0.94 (0.88, 1.00) for the first trimester, 0.93 (0.86, 1.00) for the second trimester, 1.07 (1.00, 1.15) for the third trimester, and 0.92 (0.81, 1.06) for the entire pregnancy. When a 5

show abstract

“…Moreover, several recent studies have shown the need to study exposures accurately over short periods and specific exposure windows [56]. Ren et al (2017). have recently shown for PM (whose behaviour in the atmosphere is similar to dioxins in particulate form) that exposure, one month before and after pregnancy increases the risk of birth defects [57].…”

Section: Discussionmentioning

confidence: 99%

“…Ren et al (2017). have recently shown for PM (whose behaviour in the atmosphere is similar to dioxins in particulate form) that exposure, one month before and after pregnancy increases the risk of birth defects [57]. In addition to long-term exposure assessment, this GIS indicator, thanks to the finesse of the meteorological information collected, is able to estimate exposure at a daily temporal scale over the entire French territory between 1990 and 2008 and thus minimizes potential classification bias of future epidemiological studies.…”

Section: Discussionmentioning

confidence: 99%

Development and performance evaluation of a GIS-based metric to assess exposure to airborne pollutant emissions from industrial sources

Coudon

Danjou

Faure

et al. 2018

Revue d'Épidémiologie et de Santé Publique

View full text Add to dashboard Cite

Background: Dioxins are environmental and persistent organic carcinogens with endocrine disrupting properties. A positive association with several cancers, including risk of breast cancer has been suggested. Objectives: This study aimed to develop and assess performances of an exposure metric based on a Geographic Information System (GIS) through comparison with a validated dispersion model to estimate historical industrial dioxin exposure for its use in a case-control study nested within a prospective cohort. Methods: Industrial dioxin sources were inventoried over the whole French territory (n > 2500) and annual average releases were estimated between 1990 and 2008. In three selected areas (rural, urban and urban-costal), dioxin dispersion was modelled using SIRANE, an urban Gaussian model and exposure of the French E3N cohort participants was estimated. The GIS-based metric was developed, calibrated and compared to SIRANE results using a set of parameters (local meteorological data, characteristics of industrial sources, e.g. emission intensity and stack height), by calculating weighted kappa statistics (wκ) and coefficient of determination (R 2). Furthermore, as performance evaluation, the final GIS-based metric was tested to assess atmospheric exposure to cadmium. Results: The concordance between the GIS-based metric and the dispersion model for dioxin exposure estimate was strong (wκ median = 0.78 (1st quintile = 0.72, 3rd quintile =0.82) and R 2 median = 0.82 (1st quintile = 0.71, 3rd quintile = 0.87)). We observed similar performance for cadmium. Conclusions: Our study demonstrated the ability of the GIS-based metric to reliably characterize long-term environmental dioxin and cadmium exposures as well as the pertinence of using dispersion modelling to construct and calibrate the GIS-based metric.

show abstract

Periconception Exposure to Air Pollution and Risk of Congenital Malformations

Cited by 39 publications

References 31 publications

Hypospadias Risk from Maternal Residential Exposure to Heavy Metal Hazardous Air Pollutants

Hypospadias Risk from Maternal Residential Exposure to Heavy Metal Hazardous Air Pollutants

Trimester specific PM2.5 exposure and fetal growth in Ohio, 2007–2010

Development and performance evaluation of a GIS-based metric to assess exposure to airborne pollutant emissions from industrial sources

Contact Info

Product

Resources

About