Influence of different types of light on the response of the pulp tissue in dental bleaching: a systematic review

Benetti, Francine; Lemos, Caa; Gallinari, Marjorie de Oliveira; Terayama, Amanda Miyuki; Briso, André Luiz Fraga; Jacinto, Rogério de Castilho; Sivieri-Araújo, Gustavo; Cintra, Luciano Tavares Ângelo

doi:10.1007/s00784-017-2278-9

Cited by 38 publications

(36 citation statements)

References 53 publications

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“…The intensity of inflammation was scored according to the presence of the inflammatory infiltrate as follows: 0, inflammatory cells absent or negligible in number; 1, mild inflammatory infiltrate (<25 cells per field); 2, moderate inflammatory infiltrate (between 25 and 125 cells per field); 3, severe inflammatory infiltrate (>125 cells per field); and 4, tissue necrosis (Benetti et al . ,). The analyses were performed by a single calibrated operator in a blinded manner.…”

Section: Methodsmentioning

confidence: 99%

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In vivo analysis of the presence of heme oxygenase‐1, transcription factor Jun‐D and CD90+/CD73+/CD105+/CD45‐ cells in the pulp of bleached teeth

Benetti¹,

Briso

Lopes

et al. 2019

Int Endodontic J

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Aim To investigate hydrogen peroxide (H2O2)‐induced responsiveness in pulp cells using heme oxygenase‐1 (HO‐1) immunolabelling, Jun‐D immunolabelling to study the effects of H2O2 on odontoblastic differentiation and CD90+/CD73+/CD105+/CD45‐ cell counting for in vivo identification of mesenchymal stem cells in the pulp. Methodology The maxillary molars of 50 rats were treated with a bleaching gel (35% H2O2, 1 × 30 min) or placebo gel (control groups). At 2, 3, 7, 15 and 30 days after the treatment (n = 10), inflammation in pulp tissue was analysed by haematoxylin–eosin staining, HO‐1‐ and Jun‐D‐immunolabelled cells were counted in each third of the pulp chamber, and the number of CD90+/CD73+/CD105+/CD45‐ cells was quantified by immunofluorescence. The results were assessed using the Paired t‐test or Wilcoxon signed‐rank test (P < 0.05). Results Significant H2O2‐induced inflammation was noted at 2 and 3 days (P < 0.05), with tertiary dentine formation occurring from 7 days. The bleached specimens had greater HO‐1 immunolabelling in the middle and cervical thirds of the coronal pulp at 2 and 3 days, in all thirds at 7 days, and in the occlusal third at 15 days (P < 0.05), and significant nuclear Jun‐D immunolabelling in the cervical third at 2 and 3 days and in the occlusal and middle thirds at 7 days (P < 0.05). Bleached and control groups had low numbers of CD90+/CD73+/CD105+/CD45‐ cells in the pulp at all periods (P > 0.05). Conclusions Pulp cells responded to oxidative stress by expressing HO‐1 during the post‐bleaching inflammation phase until the beginning of the repair phase. Jun‐D expression occurred during the reduction of inflammation and the beginning of tertiary dentine production. The presence of oxidative stress did not influence the number of CD90+/CD73+/CD105+/CD45‐ cells identified in vivo in the dental pulp.

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Section: Methodsmentioning

confidence: 99%

“…, Benetti et al . ). Depending on the country, patients may have access to bleaching gels and may be able to use them without the supervision of a dentist or a qualified professional (Hasson et al .…”

Section: Introductionmentioning

confidence: 97%

In vivo analysis of the presence of heme oxygenase‐1, transcription factor Jun‐D and CD90+/CD73+/CD105+/CD45‐ cells in the pulp of bleached teeth

Benetti¹,

Briso

Lopes

et al. 2019

Int Endodontic J

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“…, Benetti et al . ,b). Also, cytokines have been shown to be involved in acute inflammation 6 h after dental bleaching (Soares et al .…”

Section: Introductionmentioning

confidence: 99%

Concentration‐dependent effect of bleaching agents on the immunolabelling of interleukin‐6, interleukin‐17 and CD5‐positive cells in the dental pulp

et al. 2018

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Section: Introductionmentioning

confidence: 99%

“…Different methods and concentrations of bleaching gels have been described for bleaching vital teeth . Regardless of the method used, all are based on the use of hydrogen peroxide (H 2 O 2 ) or its precursor, carbamide peroxide . H 2 O 2 dissociates into reactive oxygen species, potent oxidizing agents, which define the bleaching mechanism as being an oxidation reaction through which the element to be bleached donates electrons to the bleaching agent .…”

Section: Introductionmentioning

confidence: 99%

Anti‐inflammatory potential of a carvedilol gel in the pulpal tissue of rats after dental bleaching: A histopathological evaluation

Louzada

Briso

Benetti

et al. 2019

J of Invest & Clin Dent

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Aim Carvedilol is an antioxidant that decreases inflammation in periodontitis. The hydrogen peroxide (H2O2) of bleaching gel causes inflammation and necrosis of the dental pulp. In the present study, we evaluated the anti‐inflammatory potential of carvedilol in the pulp of rats after bleaching. Methods The right upper molars of rats received 35% H2O2 (1× 30 minutes), and the left upper molars were used as the control. Half of the rats received carvedilol gel (1× 10 minutes), forming the following groups: bleached, bleached followed by carvedilol (bleached+carvedilol), and control. After 2 and 30 days (N = 7 hemi‐maxillae/group), the rats were killed for histological evaluation, and statistical tests were performed (P < 0.05). Results After 2 days, the bleached group showed necrosis in the occlusal third of the coronal pulp, and in the bleached+carvedilol group, severe inflammation (P > 0.05), both different from the control (P < 0.05). In the middle third, the bleached group showed severe inflammation, and the bleached+carvedilol group showed moderate inflammation (P > 0.05), with the only difference between the bleached and control groups (P < 0.05). In the cervical third, the bleached group showed moderate inflammation, and the bleached+carvedilol group showed mild inflammation (P > 0.05). The difference again was only between the bleached and control groups (P < 0.05). At 30 days, there was no inflammation and a marked amount of tertiary dentin in bleached teeth (P > 0.05). Conclusion Carvedilol gel has the potential of minimizing H2O2 damage, especially in deep regions of the dental pulp of rats after bleaching.

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Influence of different types of light on the response of the pulp tissue in dental bleaching: a systematic review

Abstract: There is insufficient evidence about the influence of different types of light on inflammation/cytotoxicity of the pulp.

Cited by 38 publications

References 53 publications

In vivo analysis of the presence of heme oxygenase‐1, transcription factor Jun‐D and CD90+/CD73+/CD105+/CD45‐ cells in the pulp of bleached teeth

In vivo analysis of the presence of heme oxygenase‐1, transcription factor Jun‐D and CD90+/CD73+/CD105+/CD45‐ cells in the pulp of bleached teeth

Concentration‐dependent effect of bleaching agents on the immunolabelling of interleukin‐6, interleukin‐17 and CD5‐positive cells in the dental pulp

Anti‐inflammatory potential of a carvedilol gel in the pulpal tissue of rats after dental bleaching: A histopathological evaluation

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