Efficacy and safety of fesoterodine treatment for overactive bladder symptoms in elderly women with and without hypertension

Yokoyama, Osamu; Yamagami, Hidetomi; Hiro, Shintaro; Hotta, Shinichi; Yoshida, Masaki

doi:10.1111/iju.13499

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…A total of 3078 abstracts, 300 of which underwent full-text screening, were identified using the search criteria. After the exclusion of studies with overlapping populations that provided no additional data [20][21][22][23][24][25][26][27], 20 articles reporting on 21 RCTs were eligible for data extraction and synthesis [23,[28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46]. Following the feasibility assessment, 14 were included in the NMA [23, 28-32, 36, 38-41, 43-45] [Fig.…”

Section: Systematic Literature Review Resultsmentioning

confidence: 99%

Comparative Safety and Efficacy of Treatments for Overactive Bladder Among Older Adults: A Network Meta-analysis

et al. 2020

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Background Cumulative exposure to one or more anticholinergic medications ("anticholinergic burden") is associated with an increased risk of adverse outcomes, particularly among older individuals. Mirabegron, an oral selective β3-adrenergic receptor agonist, has demonstrated efficacy in managing the symptoms of overactive bladder without contributing to anticholinergic burden. However, it is not known whether the favorable safety profile of mirabegron relative to antimuscarinics varies with increasing age among a patient population who may have a high anticholinergic burden. Objective The primary objective of this study was to indirectly compare the safety and efficacy profile of mirabegron relative to antimuscarinics in older adults with overactive bladder. Methods A systematic literature review was conducted to identify randomized controlled trials that reported safety and efficacy endpoints among patients aged ≥ 65 years. Identified randomized controlled trials were subsequently synthesized via a network meta-analysis. Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines in designing, performing, and reporting the literature review were followed. In line with current best practices, the network meta-analysis was conducted using a Bayesian approach and according to the overall general guidance for evidence synthesis developed by the National Institute for Health and Care Excellence decision support unit. Estimates of relative safety were assessed via the odds ratio and estimates of relative efficacy were assessed via means and credible intervals. Results A total of 3078 abstracts, 300 of which underwent full-text screening, were identified using the search criteria. Twenty articles reporting on 21 randomized controlled trials were eligible for data extraction and synthesis. Following review, five safety and five efficacy endpoints were considered for inclusion in the network meta-analysis. Regarding findings typical of anticholinergic exposure in older adults, mirabegron was not associated with an increased odds of dry mouth (odds ratio 95% credible interval 0.76 [0.26-2.37]) or constipation (1.08 [0.39-3.02]) relative to placebo, whereas antimuscarinics were strongly associated with these events (odds ratio range 3.78-7.85 and 2.12-4.66, respectively). In this older population, mirabegron was associated with a similar odds of experiencing adverse event-related treatment discontinuations relative to placebo (0.99 [0.57-1.70]), while the odds of experiencing an adverse event-related treatment discontinuation for antimuscarinics had a range of 1.14-3.03 (in most cases, the association was mild). No increased odds of experiencing overall treatment-emergent adverse events was observed for mirabegron or antimuscarinics (odds ratio range 1.25-1.55), apart from fesoterodine (2.23 [1.37-3.37]). Finally, a similar treatment effect was observed across all efficacy endpoints between mirabegron and antimuscarinics in this older population. Conclusions This study indicates that the safety and effica...

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Section: Systematic Literature Review Resultsmentioning

confidence: 99%

Comparative Safety and Efficacy of Treatments for Overactive Bladder Among Older Adults: A Network Meta-analysis

et al. 2020

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“…In the literature, there are few studies linking hypertension to OABS (8,26). However, there are many studies showing the relationship of OAB with hypertension and metabolic syndrome (27,28,29).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Possible Risk Factors of Overactive Bladder Symptoms in Women Living in the City of İzmir

İrer¹,

Şen²,

Bozkurt³

et al. 2018

jus

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What's known on the subject? and What does the study add? Öz Amaç: Türkiye'nin batı kenti İzmir'de yaşayan kadınlarda aşırı aktif mesane semptomlarının (AAMS) prevalansını ve olası risk faktörlerini değerlendirmeyi amaçladık. Gereç ve Yöntem: Validasyonu yapılmış Aşırı Aktif Mesane Semptom Skoru (OABSS) formunu içeren anket, katılımcılarla yüz yüze görüşme ile ürologlar tarafından dolduruldu. AAMS prevalansı ve yaş, obezite, komorbidite, eğitim düzeyi, evlilik durumu ve doğum sayısı gibi AAMS'nin bağımsız olası risk faktörleri değerlendirildi. AAMS olan ve olmayan katılımcılar olası risk faktörleri açısından karşılaştırıldı. Bulgular: Çalışmamıza toplam 719 kadın dahil edildi ve AAMS prevalansı %42,8 idi. İdrar kaçırma ile birlikte olan AAMS prevalansı %69,2, idrar kaçırma birlikteliği olmaksızın AAMS prevalansı %30,8 olarak bulundu ve acil sıkışma hissi ile birlikte en sık görülen semptom noktüriydi. AAMS ile noktüri ve idrar kaçırma tipleri arasında istatistiksel olarak anlamlı ilişki vardı (r=0,363, p<0,001, r=0,568, p<0,001). Çok değişkenli analize göre AAMS için temel risk faktörleri obezite, hipertansiyon, diabetes mellitus, evlilik durumu ve düşük eğitim seviyesi idi. Sonuç: İzmir ilindeki yetişkin Türk kadınlarında AAMS prevalansı %42,8 idi. Obezite, hipertansiyon, diabetes mellitus, düşük eğitim ve evli kadınlar arasında AAMS ile anlamlı ilişki vardı. Anahtar Kelimeler: Aşırı aktif mesane semptomları, Prevalans, Risk faktörleri, İdrar kaçırma Objective: We aimed to evaluate the prevalence and possible risk factors of overactive bladder symptoms (OABS) among women living in a western city of Turkiye, İzmir. Materials and Methods: A questionnaire and the validated Overactive Bladder Symptom Score were filled by urologists with face-to-face interview. The prevalence of OABS and independent possible risk factors of OABS such as age, obesity, systemic diseases, educational level, marital status and number of births were analyzed. The participants with OABS and without OABS were compared in terms of possible risk factors. Results: A total of 719 women were included and the prevalence of OABS was 42.8% in our study. The prevalence of OABS with urinary incontinence (UI) (OAB wet) was 69.2% and the prevalence of OABS without UI (OAB dry) was 30.8% and nocturia was the most common OABS besides urgency. There was a statistically significant association between OABS and presence of nocturia and UI types (r=0.363, p<0.001, r=0.568, p<0.001). The key risk factors for OABS according to multivariate analysis were obesity, hypertension, diabetes mellitus, marital status and lower education level. Conclusion: The prevalence of OABS was 42.8% among adult Turkish women in the city of İzmir. Obesity, hypertension, diabetes mellitus, lower education and being married were significantly related to OABS in women.

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“…Existen estudios que sugieren que hay una relación entre la severidad de los síntomas de vejiga hiperactiva, la hipertensión y la obesidad en mujeres mayores. Sin embargo, que los pacientes presenten o no hipertensión parece que no influye en la eficacia del tratamiento, en este caso, de la Festerodina (217).…”

Section: Análisis De Los Diagnósticos Secundariosunclassified

Implicaciones clínicas del tratamiento de la vejiga hiperactiva en la patología oftalmológica

Muñiz¹

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Efficacy and safety of fesoterodine treatment for overactive bladder symptoms in elderly women with and without hypertension

Cited by 3 publications

References 30 publications

Comparative Safety and Efficacy of Treatments for Overactive Bladder Among Older Adults: A Network Meta-analysis

Comparative Safety and Efficacy of Treatments for Overactive Bladder Among Older Adults: A Network Meta-analysis

Prevalence and Possible Risk Factors of Overactive Bladder Symptoms in Women Living in the City of İzmir

Implicaciones clínicas del tratamiento de la vejiga hiperactiva en la patología oftalmológica

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