Streptococcus agalactiae bacteremia in non-pregnant adult patients at two teaching hospitals

Abstract

Streptococcus agalactiae or group B streptococcus (GBS) is a frequent pathogen in immunocompromised adults. The aim of this study was to determine the relative frequency, clinical presentation, antimicrobial susceptibility profile, and risk factors associated with GBS bacteremia in non-pregnant adult patients. We conducted a retrospective analysis of blood cultures performed in two hospitals between the years 2009-2013. From 1110 bacteremia episodes, 13 were caused by GBS, all of which were susceptible to ampicillin. GBS bacteremia was more frequent in females and in patients older than 60 years of age. The most frequent comorbidities were chronic kidney disease, cardiac failure and neoplasia. History of appendectomy was detected in 53.8% of the patients, being the most relevant comorbidity for GBS bacteremia in the multivariate analysis (OR 4.13, p=0.012). The main presentations were primary bacteremia and soft tissue infection. GBS bacteremia was infrequent in our institution, and a history of appendectomy might be related to bacteremia occurrence.

Recurrent Group B Streptococcus Septicemia Secondary to Portal Hypertensive Colopathy

“…The salient features of this case, namely, risk factors specific to GBS bacteremia without focus and risk factors for recurrent disease, are poorly described within the literature. Saad et al 20 reported 13 cases of GBS bacteremia, of which only 5 were without a definitive source in an audit of 1110 cases of bacteremia caused by various organisms. In multivariate analysis, a history of appendectomy (OR, 4.13; 95% CI, 1.37–12.45; P = 0.012) was the only comorbidity significantly different in incidence between GBS bacteremia and bacteremia caused by other organisms groups.…”

“…We performed a review of the literature regarding risk factors pertaining to this presentation, by key word searching “group B streptococcus” in Scopus, CINAHL, Embase, and PubMed. The findings of the retrieved studies are presented in Table 2 1–28 . Group B streptococcal infections (GBSs) in nonpregnant adults have become an increasingly recognized entity.…”

Medical management of septic arthritis of sternoclavicular joint

“…As group B streptococcal bacteremia is rare in non-pregnant adults, it may occur without apparent focus or with soft tissue infection. [ 14 ]…”

Streptococcus Agalactiae Infective Endocarditis in a Healthy Middle-aged Man: Uncommon but Life-threatening

“…Less commonly, it causes endocarditis, urinary tract infection, and abdominal infections [ 3 - 6 ]. The risk factors for developing invasive S. agalactiae infections include chronic kidney disease, cardiac failure, history of neoplasia, history of ischemic heart disease, and diabetes mellitus [ 5 ]. S. agalactiae endocarditis is an aggressive disease with a significant rate of local and systemic complications [ 6 ].…”