Chemoprevention by resveratrol and pterostilbene: Targeting on epigenetic regulation

Lee, Pei‐Sheng; Chiou, Yi‐Shiou; Ho, Chi‐Tang; Pan, Min‐Hsiung

doi:10.1002/biof.1401

Cited by 63 publications

(47 citation statements)

References 65 publications

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“…Recently, Res has been found to modify epigenetic mechanisms (Fernandes, Silva, & Pavan, 2017;Lee, Chiou, Ho, & Pan, 2017) by affecting enzyme activities. Considering that the deacetylase SIRT1 can be effectively activated by Res (Borra, Smith, & Denu, 2005;Hubbard et al, 2013), we first examined changes in Sirt1 expression.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol improved the developmental potential of oocytes after vitrification by modifying the epigenetics

Chen

Zhang

Wang

et al. 2019

Molecular Reproduction Devel

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Resveratrol (Res) has been reported to be able to improve oocyte vitrification because of its antioxidative properties. The objective of this study was to further assess the positive effect of Res addition on the developmental potential of vitrified mouse oocytes from the perspective of epigenetic alterations. First, 2 μM Res was chosen as the optimal concentration on the basis of its effects on survival and its antioxidative properties. We found that Res addition significantly promoted fertilization (63.8% vs. 42.9%) and blastocyst formation (68.3% vs. 50.2%) after oocyte vitrification. The quality of the derived blastocysts was also higher after Res treatment. Regarding epigenetic aspects, the expression of the important deacetylase SIRT1 was found to decrease significantly upon vitrification, but it was rescued by Res. The abnormal levels of H3K9 acetylation and DNA methylation in vitrified oocytes were restored by Res addition. Moreover, the expression of several imprinted genes was affected by oocyte vitrification. Among them, abnormal Gtl2 and Peg3 expression levels were restored by Res addition. Therefore, the methylation of their imprinted control regions (ICRs) was examined. Surprisingly, the abnormal patterns of Gtl2 and Peg3 methylation in blastocysts developed from vitrified oocytes were both restored by Res addition. Finally, the full‐term embryonic development showed that the birth rate was improved significantly by Res addition (56.2% vs. 38.1%). Collectively, Res was beneficial for the pre‐ and postimplantation embryonic development. Except for the antioxidative activity, Res also played a role in the correction of some abnormal epigenetic modifications caused by oocyte vitrification.

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Section: Discussionmentioning

confidence: 99%

Resveratrol improved the developmental potential of oocytes after vitrification by modifying the epigenetics

Chen

Zhang

Wang

et al. 2019

Molecular Reproduction Devel

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“…Recently, only two reports appeared on the chemoprevention by Rsvtrl in combination with pterostilbene and linoleic acid. These reports suggest synergistic effect of Rsvtrl in epigenetic regulation, fatty acid uptake and inhibition of lipogenesis respectively (Arias et al, ; Lee, Chiou, Ho, & Pan, ).…”

Section: Discussionmentioning

confidence: 97%

Resveratrol attenuates Nitrosodiethylamine-induced liver injury in anti-inflammatory mannerviaregulating cyclooxygenase-2

Mukherjee

Ahmad

2018

J Food Biochem

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Resveratrol is a polyphenolic phytoalexin with numerous health benefits including fat reducing ability as well as anti‐proliferative and pro‐apoptotic properties. It is found in fruits such as raspberry, strawberry, and grapes. Considering nutritional importance of Resveratrol, this study was undertaken to investigate its hepatoprotective effect against Nitrosodiethylamine (NDEA)‐induced liver injury in rats. Resveratrol was administered to NDEA‐intoxicated rats for 2 weeks. Hepato‐somatic Index (HSI), Aspartate Transaminase (AST), Alanine Transaminase (ALT), Alkaline Phosphatase (ALP), Lipid peroxides (LPO), Superoxide Dismutase (SOD), glycogen, and Na+/K+, Ca2+, Mg2+ ATPase activities were determined. Alteration in the liver anatomy was monitored by Haematoxylin and Eosin and Masson’s Trichrome stainings. Cycloxygenase‐2 (COX‐2) activity was assessed by Immunohistochemistry and Western blotting. Resveratrol restitutes the NDEA‐induced decline in HSI, glycogen, SOD, ATPases, and coincidental increase in AST, ALT, ALP, and LPO. Resveratrol refurbishes architectural changes, reduces collagen amassing and COX‐2 positive cells in the liver. This study reveals that Resveratrol offers hepatoprotection against NDEA‐induced injury through its anti‐inflammatory action and declining COX‐2 expression. Practical applications Despite various documented roles of Resveratrol, there is still a paucity of literature supporting its hepatoprotective role. The growing prevalence of liver diseases has witnessed a surge of interest in medicinally important botanicals wherein hepatoprotective active ingredients can be identified. Although herbal medication is preferred over synthetic pharmaceuticals because of their inherent efficacy and negligible side‐effects, identification and mode of action of active ingredients requires compatible attention. This study is the first that reveals anti‐inflammatory potential of Resveratrol, exerted via declining COX‐2 that offers hepatoprotection against NDEA‐induced liver fibrosis. These findings suggest Resveratrol as a potential anti‐fibrotic agent and the COX‐2 as a prospective target for drug discovery.

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“…Along with resveratrol, pterostilbene, a dimethylether analog of resveratrol, primarily found in blueberries, almonds, peanuts, and grapes, has also shown bioactivities such as chemopreventive activity (Figure ) . It is important to note that pterostilbene exhibited higher oral availability than that from resveratrol due to its two methoxy groups .…”

Section: Health Promoting Potentials Of Dietary Phytochemicalsmentioning

confidence: 99%

Targeting the NLRP3 Inflammasome in Neuroinflammation: Health Promoting Effects of Dietary Phytochemicals in Neurological Disorders

Hung

Pan

2019

Molecular Nutrition Food Res

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Neurological disorders occur in the central and peripheral nervous system and include Alzheimer's disease, stroke, and spinal cord injury. Activation of the innate immune system inevitably occurs in all forms of neurological disorders. The NOD‐, LRR‐ and pyrin domain‐containing 3 (NLRP3) inflammasome is a multimolecular complex that can sense danger signals associated with neurological disorders. Assembly of the NLRP3 inflammasome promotes caspase‐1‐mediated interleukin‐1β and interleukin‐18 maturation in microglia, where neuroinflammation contributes to neurological disease development and progression. Thus, this review attempts to elucidate the current knowledge regarding NLRP3 inflammasome activation and its crucial role in the pathogenesis of neurological disorders. Recent scientific findings with respect to neuroprotective effects of dietary phytochemicals against NLRP3 inflammasome‐mediated neurological disorders summarized in this review suggest that modulation of the NLRP3 inflammasome assembly by plant‐derived phytochemicals could be a potential strategy for prevention or treatment of neurological disorders.

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Chemoprevention by resveratrol and pterostilbene: Targeting on epigenetic regulation

Cited by 63 publications

References 65 publications

Resveratrol improved the developmental potential of oocytes after vitrification by modifying the epigenetics

Resveratrol improved the developmental potential of oocytes after vitrification by modifying the epigenetics

Resveratrol attenuates Nitrosodiethylamine-induced liver injury in anti-inflammatory mannerviaregulating cyclooxygenase-2

Targeting the NLRP3 Inflammasome in Neuroinflammation: Health Promoting Effects of Dietary Phytochemicals in Neurological Disorders

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