Pericytes modulate myelination in the central nervous system

Azevedo, Patrick O.; Sena, Isadora F. G.; Andreotti, Julia P.; Carvalho‐Tavares, Juliana; Alves‐Filho, José C.; Cunha, Thiago Mattar; Cunha, Fernando Q.; Mintz, Akiva; Birbrair, Alexander

doi:10.1002/jcp.26348

Cited by 37 publications

(26 citation statements)

References 103 publications

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“…Nevertheless, pericytes have been shown to be heterogeneous regarding their phenotype, distribution, origin, marker expression, and function [62]. Pericytes associated with different blood vessel types differ in their morphology, markers, and function [60,[63][64][65][66][67][68][69]. At least two pericyte subpopulations have been described in the brain.…”

Section: Pericytes Heterogeneitymentioning

confidence: 99%

Glioblastoma‐activated pericytes support tumor growth via immunosuppression

et al. 2018

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Glioblastoma multiforme is the most common and aggressive primary brain tumor, with an extremely poor prognosis. The lack of detailed knowledge about the cellular and molecular mechanisms involved in glioblastoma development restricts the design of efficient therapies. A recent study using state‐of‐art technologies explores the role of pericytes in the glioblastoma microenvironment. Glioblastoma‐activated pericytes develop an immunosuppressive phenotype, reducing T‐cell activation through the induction of an anti‐inflammatory response. Strikingly, pericytes support glioblastoma growth in vitro and in vivo. Here, we describe succinctly the results and implications of the findings reported in pericytes' and glioblastomas' biology. The emerging knowledge from this study will be essential for the treatment of brain tumors.

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Section: Pericytes Heterogeneitymentioning

confidence: 99%

Glioblastoma‐activated pericytes support tumor growth via immunosuppression

et al. 2018

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“…Based on those initial criteria, it was suggested that mesenchymal stem cells have a common origin. Due to the broad organ distribution of mesenchymal stem cells, the attention had turned to pericytes as candidates to be the mesenchymal stem cells . Mesenchymal stem cells/pericytes have been shown to be heterogeneous in the skin and differ in their functions as well .…”

Section: Perspectives/future Directionsmentioning

confidence: 99%

Macrophage‐derived GPNMB accelerates skin healing

Silva

Prazeres

Paiva

et al. 2018

Experimental Dermatology

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Healing is a vital response important for the re-establishment of the skin integrity following injury. Delayed or aberrant dermal wound healing leads to morbidity in patients. The development of therapies to improve dermal healing would be useful. Currently, the design of efficient treatments is stalled by the lack of detailed knowledge about the cellular and molecular mechanisms involved in wound healing. Recently, using state-of-the-art technologies, it was revealed that macrophages signal via GPNMB to mesenchymal stem cells, accelerating skin healing. Strikingly, transplantation of macrophages expressing GPNMB improves skin healing in GPNMB-mutant mice. Additionally, topical treatment with recombinant GPNMB restored mesenchymal stem cells recruitment and accelerated wound closure in the diabetic skin. From a drug development perspective, this GPNMB is a new candidate for skin healing.

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“…Pericytes are heterogeneous regarding their distribution, phenotype, marker expression, origin, and function [16,31–47], several subtypes have been characterized in various organs [11,17–20], including the heart [21]. Cardiac pericytes subpopulations, type-1 (NG2 +/Nestin-GFP−) and type-2 (NG2 +/Nestin-GFP +) pericytes, were identified in the perivascular space of cardiac blood vessels using bitransgenic Nestin-GFP/NG2-DsRed mice [21].…”

Section: Perspectives/future Directionsmentioning

confidence: 99%

Pericytes constrict blood vessels after myocardial ischemia

Costa

Paiva

Andreotti

et al. 2018

Journal of Molecular and Cellular Cardiology

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No-reflow phenomenon is defined as the reduced blood flow after myocardial ischemia. If prolonged it leads to profound damages in the myocardium. The lack of a detailed knowledge about the cells mediating no-reflow restricts the design of effective therapies. Recently, O'Farrell et al. (2017) by using state-of-the-art technologies, including high-resolution confocal imaging in combination with myocardial ischemia/reperfusion mouse model, reveal that pericytes contribute to the no-reflow phenomenon post-ischemia in the heart. Strikingly, intravenous adenosine increased vascular diameter at pericyte site after cardiac ischemia. This study provides a novel therapeutic target to inhibit no-reflow phenomenon after myocardial ischemia.

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Pericytes modulate myelination in the central nervous system

Cited by 37 publications

References 103 publications

Glioblastoma‐activated pericytes support tumor growth via immunosuppression

Glioblastoma‐activated pericytes support tumor growth via immunosuppression

Macrophage‐derived GPNMB accelerates skin healing

Pericytes constrict blood vessels after myocardial ischemia

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