Auditory Related Resting State fMRI Functional Connectivity in Tinnitus Patients: Tinnitus Diagnosis Performance

Minami, Shujiro; Oishi, Naoki; Watabe, Toshihisa; Uno, Kimiichi; Ogawa, Kaoru

doi:10.1097/mao.0000000000001626

Cited by 24 publications

(22 citation statements)

References 14 publications

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“…We have reported that the tinnitus patients showed less auditory‐related FC compared with the control group . When rs‐fMRI positive is defined as less than 9% of all possible connections between auditory‐related ROIs with a beta threshold of more than 0.7, the sensitivity of tinnitus diagnosis is 86%, the specificity is 74% . Because the older patients tend to decrease in the objective diagnostic yield for tinnitus, we examined the age‐related change of the auditory FC using the HCP database.…”

Section: Discussionmentioning

confidence: 99%

“…The significance threshold was set at P < .05 (false discovery rate‐corrected). As auditory‐related regions, Heschl's gyrus, planum temporaleale, planum polare, operculum, insular cortex, and superior temporal gyrus were set as the ROI from our previous reports …”

Section: Methodsmentioning

confidence: 99%

“…As auditory-related regions, Heschl's gyrus, planum temporaleale, planum polare, operculum, insular cortex, and superior temporal gyrus were set as the ROI from our previous reports. 5,6 We used our tinnitus patients' resting fMRI database, whose study was approved by the ethics committee of Keio University, to compare with the HCP database. The inclusion criteria for tinnitus patients were more than 20 years of age, suffering from chronic (more than 3 months) tinnitus and giving written informed consent.…”

Section: Methodsmentioning

confidence: 99%

“…Rs‐fMRI is used to study connectivity in the brain by acquiring fMRI data from a subject lying “at rest” in the scanner and is based upon the premise that spontaneous activity patterns in functionally related brain regions are temporally correlated . We previously reported that tinnitus patients with or without hearing loss showed reduced levels of statistically significant auditory related FC in comparison with normal hearing control subjects, and we succeeded in objective diagnosis of tinnitus with 86% sensitivity and 74% specificity by focusing only on auditory‐related FC . The prevalence of hearing loss and tinnitus is more common in the older population compared with the younger population .…”

Section: Introductionmentioning

confidence: 99%

“…4 We previously reported that tinnitus patients with or without hearing loss showed reduced levels of statistically significant auditory related FC in comparison with normal hearing control subjects, 5 and we succeeded in objective diagnosis of tinnitus with 86% sensitivity and 74% specificity by focusing only on auditory-related FC. 6 The prevalence of hearing loss and tinnitus is more common in the older population compared with the younger population. 7 However, agerelated changes of auditory FC have not been clarified.…”

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confidence: 99%

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Age‐related change of auditory functional connectivity in Human Connectome Project data and tinnitus patients

Minami

Oishi

Watabe

et al. 2020

Laryngoscope Investig Oto

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Background We reported that tinnitus patients showed reduced levels of auditory functional connectivity (FC) in comparison with normal hearing control subjects, and that we succeeded in objective diagnosis of tinnitus with 86% sensitivity and 74% specificity by focusing only on auditory‐related FC. However, the age‐related change of auditory FC is not clarified. In this study, we examine age‐related change of the auditory FC using the database of Human Connectome Project (HCP) and compared with our database of tinnitus patients. Method From the HCP database HCP Lifespan Pilot project, we studied five age groups, 8 to 9 years old, 14 to 15, 25 to 35, 45 to 55, and 65 to 75. We also applied our tinnitus patients' resting‐state functional magnetic resonance imaging (fMRI) database, which is divided into three generations; 20 to 40 years old, 40 to 60, and 60 to 80 to compare with the HCP database. The resting state fMRI analyses were performed using the CONN toolbox version 18. As auditory‐related regions, Heschl's gyrus, planum temporale, planum polare, operculum, insular cortex, and superior temporal gyrus were set as the regions of interest from our previous reports. Result Auditory FC is strongest among adolescents and reduces with age. But the auditory FC of tinnitus patients were significantly less than those of HCP data in each generation. Conclusion Although auditory FC decreases with age, tinnitus patients have less auditory FC compared with age‐matched controls. The age‐matched cutoff values are necessary for an objective diagnosis of tinnitus with resting state fMRI.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Age‐related change of auditory functional connectivity in Human Connectome Project data and tinnitus patients

Minami

Oishi

Watabe

et al. 2020

Laryngoscope Investig Oto

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Resting-state Networks in Tinnitus

et al. 2022

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Chronic subjective tinnitus is the constant perception of a sound that has no physical source. Brain imaging studies show alterations in tinnitus patients’ resting-state networks (RSNs). This scoping review aims to provide an overview of resting-state fMRI studies in tinnitus, and to evaluate the evidence for changes in different RSNs. A total of 29 studies were included, 26 of which found alterations in networks such as the auditory network, default mode network, attention networks, and visual network; however, there is a lack of reproducibility in the field which can be attributed to the use of different regions of interest and analytical methods per study, and tinnitus heterogeneity. Future studies should focus on replication by using the same regions of interest in their analysis of resting-state data, and by controlling adequately for potential confounds. These efforts could potentially lead to the identification of a biomarker for tinnitus in the future.

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The impact of tinnitus on speech perception in noise: a systematic review and meta-analysis

Madhukesh,

Palaniswamy,

Ganapathy

et al. 2024

Eur Arch Otorhinolaryngol

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Purpose Tinnitus is a condition that causes people to hear sounds without an external source. One significant issue arising from this condition is the difficulty in communicating, especially in the presence of noisy backgrounds. The process of understanding speech in challenging situations requires both cognitive and auditory abilities. Since tinnitus presents unique challenges, it is important to investigate how it affects speech perception in noise. Method In this review, 32 articles were investigated to determine the effect of tinnitus on the effect of speech in noise perception performance. Based on the meta-analysis performed using a random-effects model, meta-regression was used to explore the moderating effects of age and hearing acuity. Results A total of 32 studies were reviewed, and the results of the meta-analysis revealed that tinnitus significantly impacts speech in terms of noise perception performance. Additionally, the regression analysis revealed that age and hearing acuity are not significant predictors of speech in noise perception. Conclusion Our findings suggest that tinnitus affects speech perception in noisy environments due to cognitive impairments and central auditory processing deficits. Hearing loss and aging also contribute to reduced speech in noise performance. Interventions and further research are necessary to address individual challenges associated with continuous subjective tinnitus.

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Auditory Related Resting State fMRI Functional Connectivity in Tinnitus Patients: Tinnitus Diagnosis Performance

Abstract: The associations between auditory-related networks are weakened in tinnitus patients, even if they have normal hearing. It is possible that rs-fMRI can be a tool for objective examination of tinnitus, by focusing the auditory-related areas.

Cited by 24 publications

References 14 publications

Age‐related change of auditory functional connectivity in Human Connectome Project data and tinnitus patients

Age‐related change of auditory functional connectivity in Human Connectome Project data and tinnitus patients

Resting-state Networks in Tinnitus

The impact of tinnitus on speech perception in noise: a systematic review and meta-analysis

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