Serum adipokines (adiponectin and resistin) correlation in developing gestational diabetes mellitus: pilot study

Siddiqui, Khalid; George, Teena P.; Nawaz, Shaik Sarfaraz; Shehata, Nevene; El-Sayed, Amel A. F.; Khanam, Latifa

doi:10.1080/09513590.2017.1411472

Cited by 9 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study of Kuzmicki et al[14] was assigned to the “14-28 wk” subgroup. The studies of Kralisch et al[39], Siddiqui et al[25], and Palik et al[17] were assigned to the subgroup of “after 28 wk”. Additionally, based on the “need for insulin in GDM patients”, the subjects were divided into three subgroups: (1) need for insulin; (2) no need for insulin; and (3) no information.…”

Section: Methodsmentioning

confidence: 99%

Maternal serum level of resistin is associated with risk for gestational diabetes mellitus: A meta-analysis

Chen

Tan

2019

WJCC

View full text Add to dashboard Cite

BACKGROUND Resistin is most likely involved in the pathogenesis of gestational diabetes mellitus (GDM), but the existing findings are inconsistent. AIM To review the literature investigating the associations of the risk of GDM with serum level of resistin. METHODS A systematic literature search was performed using MEDLINE, EMBASE, and Web of Science (all databases). This meta-analysis included eligible studies that: (1) investigated the relationship between the risk of GDM and serum resistin; (2) included GDM cases and controls without GDM; (3) diagnosed GDM according to the oral glucose-tolerance test; (4) were performed in humans; (5) were published as full text articles in English; and (6) provided data with median and quartile range, median and minimum and maximum values, or mean and standard deviation. The pooled standardized mean difference (SMD) and 95% confidence interval (CI) were calculated to estimate the association between the risk of GDM and serum resistin. To analyze the potential influences of need for insulin in GDM patients and gestational age at blood sampling, we performed a subgroup analysis. Meta-regression with restricted maximum likelihood estimation was performed to assess the potentially important covariate exerting substantial impact on between-study heterogeneity. RESULTS The meta-analysis for the association between serum resistin level and GDM risk included 18 studies (22 comparisons) with 1041 cases and 1292 controls. The total results showed that the risk of GDM was associated with higher serum resistin level (SMD = 0.250, 95%CI: 0.116, 0.384). The “after 28 wk” subgroup, “no need for insulin” subgroup, and “need for insulin” subgroup indicated that higher serum resistin level was related to GDM risk (“after 28 wk” subgroup: SMD = 0.394, 95%CI: 0.108, 0.680; “no need for insulin” subgroup: SMD = 0.177, 95%CI: 0.018, 0.336; “need for insulin” subgroup: SMD = 0.403, 95%CI: 0.119, 0.687). The “before 14 wk” subgroup, “14-28 wk” subgroup, and “no information of need for insulin” subgroup showed a nonsignificant association between serum resistin level and GDM risk (“before 14 wk” subgroup: SMD = 0.087, 95%CI: -0.055, 0.230; “14-28 wk” subgroup: SMD = 0.217, 95%CI: -0.003, 0.436; “no information of need for insulin” subgroup: SMD = 0.356, 95%CI: -0.143, 0.855). The postpartum subgroup included only one study and showed that higher serum resistin level was related to GDM risk (SMD = 0.571, 95%CI: 0.054, 1.087) The meta-regression revealed that no need for insulin in GDM patients, age distribution similar between cases and controls, and ELISA all had a significant impact on between-study heterogeneity. CONCLUSION This meta-analysis supports that the maternal serum resistin level is associated with GDM risk.

show abstract

Section: Methodsmentioning

confidence: 99%

Maternal serum level of resistin is associated with risk for gestational diabetes mellitus: A meta-analysis

Chen

Tan

2019

WJCC

View full text Add to dashboard Cite

show abstract

“…Five studies, including two case-control studies, two cohort studies and a prospective observational study with 133, 80, 236, 480 and 196 participants, respectively, as well as one meta-analysis including 11 studies, found no significant difference in resistin levels between GDM and non-GDM pregnant controls [16][17][18][19][20][21]. Four further studies, including two case-control studies with 90, 208, 140 and 130 participants, respectively, observed resistin to be significantly elevated in GDM patients [22][23][24][25], and maternal serum resistin levels were found to correlate positively with the known GDM risk factor LDL cholesterol [22]. Resistin levels in the first and second trimesters were also reported to be positively associated with glycated hemoglobin (HbA1c) in GDM mothers [25].…”

Section: Resistin In Gdm and Pementioning

confidence: 99%

Adipokines in Pregnancy: A Systematic Review of Clinical Data

et al. 2023

View full text Add to dashboard Cite

Adipokines are signaling proteins involved in metabolic, endocrinological, vascular and immunogenic processes. Associations of various adipokines with not only insulin resistance but also with increased insulin sensitivity, increased systolic blood pressure, and atherosclerosis highlight the significance of adipokines in several components of metabolic syndrome and metabolic diseases in general. As pregnancy presents a unique metabolic state, the role of adipokines in pregnancy, and even in various pregnancy complications, appears to be key to elucidating these metabolic processes. Many studies in recent years have attempted to clarify the role of adipokines in pregnancy and gestational pathologies. In this review, we aim to investigate the changes in maternal adipokine levels in physiological gestation, as well as the association of adipokines with pregnancy pathologies, such as gestational diabetes mellitus (GDM) and preeclampsia (PE). Furthermore, we will analyze the association of adipokines in both maternal serum and cord blood with parameters of intrauterine growth and various pregnancy outcomes.

show abstract

“…This relationship has led us to think that we need to work on this topic with more examples and more comprehensively. Shang et al [ 33 ] showed negative correlation between adiponectin an dresistin levels, while Siddiqui et al [ 34 ] found loweradiponectin and higher resistin levels inwomen with GDM. Guelfi et al [ 35 ] showed decrease inmaternal adiponectin concentrations an increase in leptin and resistin levels with the progression of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Gestational Diabetes Mellitus and Adipocytokine Levels

Törün¹

2022

Sisli Etfal

View full text Add to dashboard Cite

Objectives: The aim of this study was to compare adiponectin, resistin, visfatin, and irisin levels between pregnant women diagnosed gestational diabetes mellitus (GDM) and healthy pregnant women and to evaluate the role of these parameters in GDM pathophysiology and early diagnosis. Methods: Fifty GDM and 50 healthy pregnant women were included in the study. Anthropometric measurements of pregnant women were performed. Fasting blood glucose, hemoglobin A1c, 75 gr OGTT, low density lipoprotein, triglyceride, and complete blood count results were recorded. Adiponectin, irisin, visfatin, resistin, and C-reactive protein (CRP) levels were evaluated. Results: Serum adiponectin levels were significantly lower (p<0.001) and serum resistin and CRP levels were significantly higher (p=0.000 and p=0.027, respectively) in pregnant women with GDM compared to healthy pregnants. There was no significant difference between groups according to serum irisin and visfatin levels (p=0.942 and p=0.332, respectively). There was a negative correlation between adiponectin level and FPG, visfatin, and resistin, while a positive correlation was found between irisin level. While there was a positive correlation between resistin and CRP levels, there was a negative correlation between adiponectin level. While there was a positive correlation between irisin and adiponectin levels, there was a negative correlation between weight and body mass index. Conclusion: In this study, we think that elevated serum resistin and CRP levels and decreased adiponectin levels in GDM patients may play a role in glucose metabolism changes. Further studies are needed on this subject.

show abstract

Serum adipokines (adiponectin and resistin) correlation in developing gestational diabetes mellitus: pilot study

Cited by 9 publications

References 29 publications

Maternal serum level of resistin is associated with risk for gestational diabetes mellitus: A meta-analysis

Maternal serum level of resistin is associated with risk for gestational diabetes mellitus: A meta-analysis

Adipokines in Pregnancy: A Systematic Review of Clinical Data

The Relationship Between Gestational Diabetes Mellitus and Adipocytokine Levels

Contact Info

Product

Resources

About