“…Moreover, a weak band at approximately 860 cm −1 in GUPS-II was attributed to α-glycosidic linkages in the polysaccharide chains. Another weak band at 1250-1244 cm −1 in GUPS-III was regarded as the S=O vibration, suggesting that GUPS-III may consist of sulfated polysaccharides [39][40][41]. This is in consistent with the sulfate content of GUPS-III.…”
Section: The Analysis Of Gups By Ft-ir Spectroscopysupporting
Glycyrrhiza uralensis is a Chinese herbal medicine with various bioactivities. Three fractions (GUPS-I, GUPS-II and GUPS-III) of G. uralensis polysaccharides (GUPS) were obtained with molecular weights of 1.06, 29.1, and 14.9 kDa, respectively. The monosaccharide compositions of GUPS-II and GUPS-III were similar, while that of GUPS-I was distinctively different. The results of scanning electron microscopy, FT-IR, and NMR suggested that GUPS-II and GUPS-III were flaky with a smooth surface and contained α- and β-glycosidic linkages, while GUPS-I was granulated and contained only α-glycosidic linkages. Moreover, GUPS-II and GUPS-III exhibited better bioactivities on the maturation and cytokine production of dendritic cells (DCs) in vitro than that of GUPS-I. An in vivo experiment showed that only GUPS-II significantly enhanced the maturation of DCs. These results indicate that GUPS-II has the potential to be used in combination with cancer immunotherapy to enhance the therapeutic effect.
“…Moreover, a weak band at approximately 860 cm −1 in GUPS-II was attributed to α-glycosidic linkages in the polysaccharide chains. Another weak band at 1250-1244 cm −1 in GUPS-III was regarded as the S=O vibration, suggesting that GUPS-III may consist of sulfated polysaccharides [39][40][41]. This is in consistent with the sulfate content of GUPS-III.…”
Section: The Analysis Of Gups By Ft-ir Spectroscopysupporting
Glycyrrhiza uralensis is a Chinese herbal medicine with various bioactivities. Three fractions (GUPS-I, GUPS-II and GUPS-III) of G. uralensis polysaccharides (GUPS) were obtained with molecular weights of 1.06, 29.1, and 14.9 kDa, respectively. The monosaccharide compositions of GUPS-II and GUPS-III were similar, while that of GUPS-I was distinctively different. The results of scanning electron microscopy, FT-IR, and NMR suggested that GUPS-II and GUPS-III were flaky with a smooth surface and contained α- and β-glycosidic linkages, while GUPS-I was granulated and contained only α-glycosidic linkages. Moreover, GUPS-II and GUPS-III exhibited better bioactivities on the maturation and cytokine production of dendritic cells (DCs) in vitro than that of GUPS-I. An in vivo experiment showed that only GUPS-II significantly enhanced the maturation of DCs. These results indicate that GUPS-II has the potential to be used in combination with cancer immunotherapy to enhance the therapeutic effect.
“…Recently, it was reported that α-glucosidase inhibitory effect of polysaccharides from blackcurrant ( Xu et al, 2018a , b , c ) or from blackberry ( Dou et al, 2019 ) was enhanced by ultrasound degradation of the polysaccharide.…”
Section: Digestion – From High To Lower Molar Massmentioning
confidence: 99%
“…Although the molar mass seems to be the key factor to determine the activities, slight difference in monosaccharide composition or linkage patterns may inhibit the comparison or not is expected to be clarified. The authors submitted another paper before these two reports concerning the effect of sulphation on the activities of BCP ( Xu et al, 2018c ). They performed the sulphation of BCP and found that the inhibition of α-amylase activity increased with increasing degree of sulphation (DS) and the dose.…”
Section: Digestion – From High To Lower Molar Massmentioning
It is demanded to supply foods with good quality for all the humans. With the advent of aging society, palatable and healthy foods are required to improve the quality of life and reduce the burden of finance for medical expenditure. Food hydrocolloids can contribute to this demand by versatile functions such as thickening, gelling, stabilising, and emulsifying, controlling texture and flavour release in food processing. Molar mass effects on viscosity and diffusion in liquid foods, and on mechanical and other physical properties of solid and semi-solid foods and films are overviewed. In these functions, the molar mass is one of the key factors, and therefore, the effects of molar mass on various health problems related to noncommunicable diseases or symptoms such as cancer, hyperlipidemia, hyperglycemia, constipation, high blood pressure, knee pain, osteoporosis, cystic fibrosis and dysphagia are described. Understanding these problems only from the viewpoint of molar mass is limited since other structural characteristics, conformation, branching, blockiness in copolymers such as pectin and alginate, degree of substitution as well as the position of the substituents are sometimes the determining factor rather than the molar mass. Nevertheless, comparison of different behaviours and functions in different polymers from the viewpoint of molar mass is expected to be useful to find a common characteristics, which may be helpful to understand the mechanism in other problems.
“…6), this result indicates that the SF is more active for the removal of the hydroxyl radical than the alkoxyl radical. Previously, the elimination of hydroxyl radical by sulfated polysaccharides was determined using other methodologies for the formation of the reactive species (Barahona et al, 2011(Barahona et al, , 2012(Barahona et al, , 2014Sudharsan et al, 2015;Xu et al, 2017). The electron spin resonance in conjunction with the spin trapping technique ensures the formation of the hydroxyl radical, unlike other widely used tests.…”
This work is related to the structural characterization of the sulfated polysaccharide from Lessonia sp and the study of its antioxidant and antiparasitic properties. Sequential extraction afforded D-mannitol as the only low MW sugar alcohol. Extraction with 2% CaCl 2 afforded in 3.0% yield, a sulfated fucan (SF). Its major fraction (48.5% yield), isolated by ion-exchange chromatography corresponds to a linear polymer of α-l-fucopyranosil residues linked 1→3, sulfated at the O-4 and partially at O-2 positions. By alkaline extraction, sodium alginate (10.3% yield) was obtained. The antioxidant capacity of SF by ESR showed high elimination index (IC 50 , mg/mL) of hydroxyl (0.27), alkoxy (10.05), and peroxyl (82.88) radicals in relation to commercial mannitol. SF showed activity against the epimastigote form of Trypanosoma cruzi parasite (250 µg/mL) and low cytotoxicity in murine cells (367 µg/mL). The elimination capacity of radicals in aqueous medium of SF would allow its potential biomedical application.
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