Adverse Maternal and Neonatal Outcomes in Indicated Compared with Spontaneous Preterm Birth in Healthy Nulliparas: A Secondary Analysis of a Randomized Trial

The aim of this study was to evaluate the effect of causes of delivery on short-term neonatal morbidities and mortality in EPD (\ 34 gestational weeks). We retrospectively analysed the deliveries occurring between 23 ? 0 and 33 ? 6th gestational weeks at our tertiary center during 2014-2018. A total of 290 deliveries were evaluated, and 369 newborns [singletons (56.4%), twins (36.6%) and triplets (7.1%)] were included in the study. The causes of deliveries were defined as spontaneously preterm birth (n = 107, 29%), preterm premature rupture of membranes (PPROM) (n = 131, 35.5%) or iatrogenic preterm birth (n = 131, 35.5%). The rate of neonatal respiratory distress syndrome (RDS), patent ductus arteriosus, bronchopulmonary dysplasia (BPD), intraventricular haemorrhagia (IVH), necrotising enterocolitis, retinopathy of prematurity, neonatal resuscitation, sepsis and death were similar between groups. However; neonatal RDS, BPD, IVH and sepsis were found to be higher in cases with chorioamnionitis, which could be considered as subcategory of PPROM. Preterm deliveries have an adverse effect on perinatal outcomes. Also, such causes of labor might be related to varied neonatal morbidities. However, splitting to early preterm deliveries into subgroups, according to cause of delivery, did not provide further information to predict such complications except chorioamnionitis.

show abstract

The Effect of the Cause of Delivery on Neonatal Outcomes in Early Preterm Deliveries

Baran

Törer

Kalaycı

et al. 2019

Journal of Fetal Medicine

View full text Add to dashboard Cite

show abstract

Latent class analysis of placental histopathology: a novel approach to classifying early and late preterm births

Layden

Bertolet

Parks

et al. 2022

American Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

Maternal and Perinatal Outcomes in Singleton Nulliparous Spontaneous Preterm Birth with and without Preterm Premature Rupture of Membranes—A National Population-Based Cohort Study

et al. 2022

View full text Add to dashboard Cite

Objective: Preterm birth (PTB, birth before 37 gestational weeks) is the leading cause of neonatal death and a major challenge for obstetric and neonatal care. About two-thirds of PTB are spontaneous (sPTB), of which about 30% starts with preterm premature rupture of membranes (PPROM). The aim of the study was to investigate risk factors and maternal and perinatal outcomes in sPTB with and without PPROM. Study design: This is a national population-based cohort study including all singleton pregnancies in nulliparous women with spontaneous onset of labor and vaginal births (n = 266 968) registered in the Swedish Medical Birth Register 2005-2014. Spontaneous PTB with PPROM (sPTB-PPROM) and sPTB without PPROM were compared regarding risk factors and maternal and perinatal outcomes. Logistic regression was used to estimate adjusted odds ratios (aORs) with 95% confidence intervals (CIs). Adjustments were made for maternal age, body mass index, country of birth, smoking, chronic hypertension, pregestational- and gestational diabetes and gestational length. Results: sPTB-PPROM (n = 5 037), compared to sPTB without PPROM (n = 8 426), was more common in women with previous spontaneous abortions, pre-pregnancy urinary tract infections, chronic hypertension and gestational diabetes and had higher risk of postpartum endometritis (aOR 2.78, 95% CI 1.55-5.00). Infants born to women with sPTB-PPROM had lower risk of birth asphyxia (0.60, 0.43-0.83), respiratory distress syndrome (0.86, 0.70-1.00), retinopathy of prematurity (0.93, 0.92-0.94), necrotizing enterocolitis (0.95, 0.94-0.96), and higher risk of hypoglycemia (1.14, 1.01-1.28) and hyperbilirubinemia (1.28, 1.19-1.38) compared to infants born to sPTB without PPROM. Conclusion: Our findings of risk factors and distinct differences in adverse outcomes after PTB-PPROM compared to PTB without PPROM are of vital importance and might serve as a basis when elaborating programs for prevention and management of PPROM.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Adverse Maternal and Neonatal Outcomes in Indicated Compared with Spontaneous Preterm Birth in Healthy Nulliparas: A Secondary Analysis of a Randomized Trial

Abstract: Adverse maternal and neonatal outcomes were significantly more likely with IPTB than with SPTB.

Cited by 6 publications

References 16 publications

The Effect of the Cause of Delivery on Neonatal Outcomes in Early Preterm Deliveries

The Effect of the Cause of Delivery on Neonatal Outcomes in Early Preterm Deliveries

Latent class analysis of placental histopathology: a novel approach to classifying early and late preterm births

Maternal and Perinatal Outcomes in Singleton Nulliparous Spontaneous Preterm Birth with and without Preterm Premature Rupture of Membranes—A National Population-Based Cohort Study

Contact Info

Product

Resources

About