Cross-sectional associations of total plasma homocysteine with cortical β-amyloid independently and as a function of omega 3 polyunsaturated fatty acid status in older adults at risk of dementia

Hooper, Claudie; Barreto, Philipe de Souto; Coley, Nicola; Caussé, Elizabeth; Payoux, Pierre; Salabert, Anne‐Sophie; Cesari, Matteo; Andrieu, Sandrine; Bowman, Gene L.; Weiner, Michael W.; Vellas, Bruno

doi:10.1007/s12603-017-0989-x

Cited by 14 publications

(8 citation statements)

References 36 publications

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“…This association was insignificant in the multivariate regression on data from the whole sample. In addition, there was no significant association between chronic fatigue and cerebral β-amyloid load, although this was not examined separately on those with a CDR of 0.5 ( Hooper et al, 2017 ). Another drawback of the study is the use of a fatigue measure tool that was not specifically designed to capture the physiological aspect of fatigue and consisted of only two items, despite fatigue being a primary variable of interest.…”

Section: Resultsmentioning

confidence: 99%

“…A study including individuals aged 70 years or greater and diagnosed with dementia showed a weak positive association between fatigue (measured at the clinical examination that was closest to the positron emission tomography scan) and β-amyloid load in the hippocampus (β = 0.07, p = .016) in individuals with a clinical dementia rating (CDR) of 0.5 ( Hooper et al, 2017 ). Researchers carried out a sensitivity analysis on individuals of CDR of 0.5 specifically, as this subgroup had a high risk of progressing to a dementia-related illness like Alzheimer’s disease.…”

Section: Resultsmentioning

confidence: 99%

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Chronic Illness and Fatigue in Older Individuals: A Systematic Review

Torossian

Jacelon²

2020

Rehabilitation Nursing

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Background Fatigue is a symptom experienced by 40%–74% of older individuals in the United States. Despite its significance, clinicians face challenges helping individuals to manage or reduce fatigue levels. Some management issues are attributable to the ambiguity around the risk factors, consequences, and the effect of fatigue management strategies. Methods A literature review was conducted using four databases to identify themes in relation to risk factors, consequences, and management strategies from research studies about fatigue in older individuals with chronic diseases. Results Findings on fatigue risk factors, such as age, body mass index, and marital status, were contradictory. There was a positive association between fatigue and comorbidities, depression, and anxiety and a negative relationship between fatigue and physical activity, sleep, educational status, and socioeconomic status. Fatigue was perceived as a state of “feebleness” and negatively impacted individuals’ quality of life. Consequences of fatigue included tiredness, sleepiness, depression, anxiety, worse sense of purpose in life, poor self-care, and an increased β-amyloid load. Predictors of worse fatigue consequences included functional health, symptom burden, subjective health, and self-acceptance. Fatigue management strategies included physical activity, rest, sleep, maintaining normal hemoglobin levels, and acetyl- l -carnitine supplementation. Conclusion This systematic review is of value to older individuals with chronic illnesses, researchers, and clinicians who strive to improve the quality of life of individuals experiencing fatigue. To prevent undesirable consequences of fatigue, older individuals should be screened for the discussed modifiable risk factors of fatigue. The inconsistencies in the studies reviewed can guide researchers to potential research areas that require further inquiry and exploration to ground future practice on best scientific evidence

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Chronic Illness and Fatigue in Older Individuals: A Systematic Review

Torossian

Jacelon²

2020

Rehabilitation Nursing

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“…15 Data obtained from the Multidomain Alzheimer Preventive Trial in France did not find, in a cross-sectional evaluation, a correlation between amyloid load after PET imaging and plasma homocysteine levels. 16 HHCy is involved in multiple plausible pathological pathways, [17][18][19] among main ones: excitotoxicity through activation of NMDA neuronal receptor, oxidative stress, cerebrovascular effects, alteration of intracellular methylation state with DNA damage or inhibition of DNA repair systems, promotion or enhancement of mediated damage of b-amyloid and accumulation of neurofibrillary tangles, formed by tau protein. The latter have been associated especially to the activation of Cdk5, the kinase which phosphorylates tau on the sites most related to AD, and inhibition of PP2A, main enzyme responsible for dephosphorylation of P-tau.…”

Section: Discussionmentioning

confidence: 99%

Hyperhomocysteinemia and Dementia Associated With Severe Cortical Atrophy, but No Amyloid Burden

Reffo

Gabelli

2021

J Geriatr Psychiatry Neurol

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We report a case of a 77 years old patient who was admitted to our memory clinic because of progressive gait impairment and amnestic cognitive decline associated with extrapyramidal symptoms and behavioral changes. The clinical picture was consistent with a possible diagnosis of Alzheimer’s Disease associated with parkinsonian symptoms or with a Parkinson Plus syndrome. After a complete investigation, she was found to have a high plasma level of homocysteine due to homozygous methylene-tetrahydrofolate reductase (MTHFR) gene C665 T polymorphism, cognitive and motor impairment were associated with a severe cortical atrophy and mild subcortical vascular disease. PET neuroimaging excluded a significant amyloid load. Clinically, she showed improvement of the movement disorder and functional status after folate integration plus levodopa and memantine administration. We concluded for a primary degenerative dementia with movement impairment associated with persistent hyperhomocysteinemia. We hypothesized that neurodegeneration is driven by mechanisms linked to homocysteine metabolism possibly associated with tauopathy.

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“…In a cross-sectional study with older adults at risk of dementia, the potential link between plasma Hcy and cortical β-amyloid (Aβ) was explored [86]. The authors investigated the role of n-3 PUFAs in the relationship between Aβ and Hcy.…”

Section: Latest Insight and Implications For Cognitive Performance Anmentioning

confidence: 99%

The Link between Homocysteine and Omega-3 Polyunsaturated Fatty Acid: Critical Appraisal and Future Directions

Rizzo¹,

Laganà

2020

Biomolecules

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Omega-3 polyunsaturated fatty acids and B vitamins are linked to metabolic and degenerative disorders, such as cardiovascular disease and cognitive decline. In the last two decades, the interplay between B vitamins and omega-3 polyunsaturated fatty acids gained increasing attention. Expression control on enzymes involved in the pathway of homocysteine by polyunsaturated fatty acids has been proposed. The methylation process seems crucial for the metabolism of polyunsaturated fatty acids and their distribution within the body. This review summarizes the available data in humans about the link between homocysteine and omega-3 polyunsaturated fatty acids, with a special focus on the meta-analyses of randomized clinical trials. Even if the paucity of available information about the topic does not allow for definitive conclusions, a synergic action between polyunsaturated fatty acids and B vitamins may play a key role in regulating several metabolic pathways. This element could explain a stronger action on homocysteine levels when omega-3 polyunsaturated fatty acids and B vitamins are supplemented simultaneously. To date, a robust rationale of intervention to prevent metabolic diseases is lacking and could be beneficial for individual health and healthcare policy.

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Cross-sectional associations of total plasma homocysteine with cortical β-amyloid independently and as a function of omega 3 polyunsaturated fatty acid status in older adults at risk of dementia

Abstract: The role of n-3 PUFAs on the relationship between homocysteine and cerebral Aβ warrants further investigation.

Cited by 14 publications

References 36 publications

Chronic Illness and Fatigue in Older Individuals: A Systematic Review

Chronic Illness and Fatigue in Older Individuals: A Systematic Review

Hyperhomocysteinemia and Dementia Associated With Severe Cortical Atrophy, but No Amyloid Burden

The Link between Homocysteine and Omega-3 Polyunsaturated Fatty Acid: Critical Appraisal and Future Directions

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