Effect of mistletoe combined with carboxymethyl cellulose on dry eye in postmenopausal women

Abstract

Mistletoe combined with carboxymethyl cellulose eye drops can alleviate the symptoms and signs of dry eye symptoms.

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

“…Ocular surface, OSDI, tear protein, and tear film functionality were evaluated after two months of treatment; this shows a slight change for normal saline whereas enhancing the effect in CMC combined with the mistletoe eye drop group. The result shows mistletoe combined with CMC improves the symptoms of dry eye [192]. In another study, Prasad et al studied the safety and efficacy of CMC (0.5%) and HPMC (0.3%) for dry eyes due to computer vision syndrome.…”

“…Hence, its forms a metallo-polymeric material by chelating with the metal ions [188]. that is prolonged release [190] Beclomethasone dipropionate Bioavailability enhancement Transcorneal permeation parameter P app, flux and AUC 0-10h was enhanced by 4, 5.8 and 5.5 fold [191] Mistletoe Improved symptoms of dry eye Symptoms of ocular surface was improved in pateints treated with mistletoe combineded CMC [192] CMC and HPMC For dry eye OSDI and schirmer I test was 23.48, 22.75 ± 3.04 [193] Chloroquine Synergistic effect for dry eye After 3 month OSDI was 18.36 ± 4.03 bettter in groups taken chloroquin and CMC [194] CMC and glycerin Artificial tear formulation CMC-GLY gel was found to be non inferior than CMC alone as OSDI and all parameter was significant [195] CMC and hyaluronic acid synergistic effects for dry eye CMC-HA as found non inferior to CMC alone as all parameters was significant such as OSDI was −16.0 ± 16.1 and −16.9 ± 17.5 [196] CMC and hyaluronic acid Synergistic effects for dry eye with less blur vision and stickiness when blinking CMC and HA produced low shear viscosity while combined form had high shear viscoelasticity which remained unaffected therefore it was minimizing blurness and stickiness during blinking [197] Vitamin-A Enhances the stability and encapsulation NC.CMC enhanced the stability of vegetable oil-water emulsion and ensured encapsulation of vitamin A in oil phase [198] Flaxseed oil, trehalose and castor oil…”

Abnormal Fractional Amplitude of Low Frequency Fluctuation Changes in Patients With Dry Eye Disease: A Functional Magnetic Resonance Imaging Study

“…The prevalence of DE is higher in people working at video terminals and in those exposed to harsh environments, such as high altitude, low air pressure, hypoxia, wind, and strong ultraviolet light, for long periods of time. Diabetes, keratoconus surgery, pterygium, allergic conjunctivitis, dry syndrome, and ocular surface drug abuse are strong risk factors for the development of DE (Jiang et al, 2017 ). DE can seriously affect the ability to perform daily activities, such as reading, using a computer, and driving, resulting in reduced quality of life and increased social burden.…”