Role of bioactive lipofishins in prevention of inflammation and colon cancer

Lombardi, Valter; Carrera, Iván; Corzo, Lola; Cacabelos, Ramón

doi:10.1016/j.semcancer.2017.11.012

Cited by 8 publications

(14 citation statements)

References 142 publications

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“…The extract displays cytotoxic and apoptotic activity in different human tumor cell lines ( Figure 8), with a significant effect against colorectal adenocarcinoma, sarcoma, and liposarcoma ( Figure 9) [29,30,45,46] (Table 5). 2019 [46].…”

Section: Antigan (E-congerine-10423)mentioning

confidence: 99%

“…The results of a pilot clinical trial to study the effect of AntiGan on the levels of tumor markers (TM) in healthy subjects and in subjects with different types of cancer at the time of diagnosis revealed that approximately 50% of the patients presented a reduction in TM levels, and this response was much more evident in patients with cancer, when TM values were above normal levels [46] (Table 5).…”

Section: Antigan Produced In About 50% Of the Patientsmentioning

confidence: 99%

“…AntiGan induced the formation of nuclear condensation, suggesting anti-tumoral activity. Adapted from[46].…”

mentioning

confidence: 99%

“…Effects of AntiGan on cell growth inhibition in human tumor cell lines (HL-60: Acute promyelocytic leukemia; HS313.T: Lymphoma; Caco-2: Colorectal adenocarcinoma; HT-29:Colorectal adenocarcinoma; and SW-480: Colorectal adenocarcinoma)[46]. AntiGan: Summary of basic and clinical studies.…”

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confidence: 99%

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Nutrition, Health, and Disease: Role of Selected Marine and Vegetal Nutraceuticals

et al. 2020

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The investigation of new alternatives for disease prevention through the application of findings from dietary and food biotechnology is an ongoing challenge for the scientific community. New nutritional trends and the need to meet social and health demands have inspired the concept of functional foods and nutraceuticals which, in addition to their overall nutritional value, present certain properties for the maintenance of health. However, these effects are not universal. Nutrigenetics describes how the genetic profile has an impact on the response of the body to bioactive food components by influencing their absorption, metabolism, and site of action. The EbioSea Program, for biomarine prospection, and the Blue Butterfly Program, for the screening of vegetable-derived bioproducts, have identified a new series of nutraceuticals, devoid of side effects at conventional doses, with genotype-dependent preventive and therapeutic activity. Nutrigenomics and nutrigenetics provide the opportunity to explore the inter-individual differences in the metabolism of and response to nutrients, achieving optimal results. This fact leads to the concept of personalized nutrition as opposed to public health nutrition. Consequently, the development and prescription of nutraceuticals according to the individual genetic profile is essential to improve their effectiveness in the prevention and natural treatment of prevalent diseases.

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Section: Antigan (E-congerine-10423)mentioning

confidence: 99%

Section: Antigan Produced In About 50% Of the Patientsmentioning

confidence: 99%

“…AntiGan induced the formation of nuclear condensation, suggesting anti-tumoral activity. Adapted from[46].…”

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confidence: 99%

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confidence: 99%

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Nutrition, Health, and Disease: Role of Selected Marine and Vegetal Nutraceuticals

et al. 2020

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“…At present, drug, radiotherapy, and surgery interventions have been used to restrain the symptoms of the patients [ 1 , 3 ]. However, the early symptoms of colon cancer usually do not express special natures, thus it may be mistaken as inflammation [ 4 ]. Patients' conditions have been become serious when they are first diagnosed as colon cancer [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Downregulated KIF3B Induced by miR-605-3p Inhibits the Progression of Colon Cancer via Inactivating Wnt/β-Catenin

Wang

Xia²,

et al. 2021

Journal of Oncology

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Colon cancer is a common malignant disease with high morbidity and mortality, and miRNA dysfunction has been confirmed as an important reason for cancer development. Several studies have verified miR-605-3p as a tumor inhibitor while its roles in colon cancer remain uncertain. In this study, the specimen of the patients and the cell lines of colon cancer were used to observe the expression of miR-605-3p, and the CCK-8, Transwell assay, and flow cytometry assay were used to observe the functions of miR-605-3p in colon cancer cells. The downstream factors of miR-605-3p were predicted by TargetScan and then were verified by dual-luciferase reporter assay. Moreover, western blot was used to investigate the effect of miR-605-3p on Wnt/β-catenin signal pathway. The result showed that miR-605-3p was extremely downregulated in the pathological tissues and tumor cells, and miR-605-3p could effectively induce the apoptosis and impede the proliferation and invasion of the tumor cells. It was found that KIF3B was a target of KIF3B; decreased KIF3B could reverse the effects of miR-605-3p on colon cancer. Besides, the inactivated Wnt/β-catenin pathway was also observed in colon cells when miR-605-3p was upregulated, and the phenomenon could be rescued by KIF3B upregulation. In conclusion, miR-605-3p could inactivate the Wnt/β-catenin pathway induced via promoting KIF3B expression.

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Nutritional Support After Surgery of the Colon

Pucciani

D’Eugenio²

2019

Nutritional Support After Gastrointestinal Surgery

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Role of bioactive lipofishins in prevention of inflammation and colon cancer

Cited by 8 publications

References 142 publications

Nutrition, Health, and Disease: Role of Selected Marine and Vegetal Nutraceuticals

Nutrition, Health, and Disease: Role of Selected Marine and Vegetal Nutraceuticals

Downregulated KIF3B Induced by miR-605-3p Inhibits the Progression of Colon Cancer via Inactivating Wnt/β-Catenin

Nutritional Support After Surgery of the Colon

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