Prevalence of hyperhomocysteinemia and its associated factors in patients with primary hypertension in Chinese urban communities: A cross-sectional study from Nanjing

Wang, Wei; Peng, Ji; Wang, Yi; Guo, Hongmei; Bian, Rongwen; Xu, Jiaren; Xiong, Yaqing

doi:10.1080/10641963.2017.1403621

Cited by 20 publications

(15 citation statements)

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“…It is also discussed debated whether the education level or BMI might have an influence on the risk of hyperhomocysteinemia. 20 21 Diet as a risk factor for hyperhomocysteinemia has been insufficiently studied. 22 Possible effects of smoking on the risk of developing hyperhomocysteinemia are also lacking.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China

et al. 2021

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ObjectivesHyperhomocysteinemia is an independent risk factor for cardiovascular diseases. We aimed to investigate the prevalence and risk factors for hyperhomocysteinemia, especially modifiable lifestyle factors, such as smoking behaviour and dietary factors.DesignPopulation-based cross-sectional study.SettingHunan Province, ChinaParticipantsA total of 4012 participants completed the study, between July 2013 and March 2014. The median age is 55 (interquartile range: 45–63) years, with 1644 males (41%) and 2368 females (59%).Main outcome measuresHomocysteine level were measured by the microplate enzyme immunoassay method. Hyperthomocysteinemia was defined as ≥15 µmol/L. Questionnaire was used to investigate potential risk factors of hyperhomocysteinemia. Crude odd ratio (OR) or adjusted OR with 95% CI were determined by using univariable or multivariable logistic regression models.ResultsThe prevalence of hyperhomocysteinemia is 35.4% (45.4% vs 28.5% for men, women, respectively). One-year increase in age is significantly associated with 2% higher risk of hyperhomocysteinemia (OR=1.02, 95% CI: 1.01 to 1.03). One unit increase of BMI is associated with 5% higher risk of hyperhomocysteinemia (OR=1.05, 95% CI: 1.03 to 1.07). Compared with the non-smoker, smoking participants have a 24% higher risk of hyperhomocysteinemia (OR=1.24, 95% CI: 1.006 to 1.53), while the risk for those quitting smoking are not significantly different (OR=1.14, 95% CI: 0.85 to 1.54). compared with those consuming fruit and vegetable at least once every day, those consuming less than once every day had a significantly higher risk of hyperhomocysteinemia (OR=1.29, 95% CI:1.11 to 1.50). In addition, we found there were significant sex interaction with education level or alcohol drinking on the risk of hyperhomocysteinemia (pinteraction<0.05).ConclusionsHigher BMI and older age are potential risk factors for hyperhomocysteinemia. Current smoking but not quitting smoking is associated with higher risk of hyperhomocysteinemia. Fruit and vegetable consumption may have protective effect against hyperhomocysteinemia. Alcohol consumption or education level might interact to influence the risk of hyperhomocysteinemia.

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Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China

et al. 2021

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“…There are sex and age differences in H-type hypertension, and the risk of H-type hypertension is higher in men than in women and increases with age (21,22). Similarly, we found that the risk of H-type hypertension in men was 7.879 times (OR=7.879), 1.73 times (OR=1.73), and 2.354 times (OR=2.354) higher than that in women in the healthy, HHcy, and hypertension populations, respectively, indicating that men were more likely to have hypertension with HHcy.…”

Section: ' Discussionmentioning

confidence: 99%

“…' INTRODUCTION H-type hypertension, a type of essential hypertension with hyperhomocysteinemia (HHcy), is a major risk factor of cardiovascular and cerebrovascular diseases, especially stroke (1)(2)(3). It has been reported that the risk of incident stroke is 12.7 times and that of stroke-related death is 11.7 times in patients with H-type hypertension compared with those in healthy controls (4).…”

mentioning

confidence: 99%

“…Previous studies have mainly used logistic models to explore the risk factors of H-type hypertension. Wang et al demonstrated that age, sex, BMI, physical activity, smoking history, and low-density lipoprotein (LDL) cholesterol levels are associated with H-type hypertension (1). Furthermore, Han et al indicated that age, smoking, sodium intake, systolic blood pressure, uric acid levels, triglyceride levels, and creatinine levels are associated with high Hcy levels in patients with hypertension (7).…”

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confidence: 99%

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Exploration of the risk factors of essential hypertension with hyperhomocysteinemia: A hospital-based study and nomogram analysis

Wang

Fan

2021

Clinics

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OBJECTIVES: To explore the risk factors of essential hypertension with hyperhomocysteinemia (H-type hypertension) and design a nomogram to predict this risk. METHODS: A hospital-based study was conducted on 1,712 individuals, including 282 patients with H-type hypertension, 105 patients with simple hypertension, 645 individuals with hyperhomocysteinemia, and 680 healthy controls. Logistic regression and nomogram models were applied to evaluate the risk factors. RESULTS: Logistic regression showed that advanced age, male sex, high body mass index (BMI), high total cholesterol levels, high glucose levels, and high creatinine levels were risk factors of H-type hypertension in the healthy population and were integrated into the nomogram model. Advanced age, male sex, high BMI, high total cholesterol levels, and high glucose levels were shown to be risk factors of H-type hypertension in the hyperhomocysteinemia population. Male sex and high creatinine levels were shown to be risk factors of H-type hypertension in the hypertension population. Nomogram analysis showed that the total factor score ranged from 106 to 206, and the corresponding risk rate ranged from 0.05 to 0.95. CONCLUSIONS: Men are more likely to have H-type hypertension, and advanced age, high BMI, high total cholesterol levels, and high glucose levels are risk factors of H-type hypertension in healthy and hyperhomocysteinemia populations. Furthermore, high creatinine level is a risk factor of H-type hypertension in healthy and hypertension populations. Nomogram models may be used to intuitively evaluate H-type hypertension risk and provide a basis for personalized interventions.

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“…H-type hypertension (H-HTN) is a form of essential hypertension (HTN) often associated with hyperhomocysteinemia (HHCY) [ 1 ]. When human blood homocysteine level is above 15 μ mol/l, it is called hyperhomocysteinemia, and essential HTN accompanied by this sign is defined as H-HTN [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Association of MTHFR Polymorphisms with H-Type Hypertension: A Systemic Review and Network Meta-Analysis of Diagnostic Test Accuracy

Kong

Zheng

et al. 2022

International Journal of Hypertension

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Purpose. An association between MTHFR polymorphisms and H-type hypertension (H-HTN) has been investigated by epidemiological studies, but results have been inconsistent. Thus, a systematic assessment of the association was performed based on a literature review and pooled analysis, to provide stronger evidence on the effects of single nucleotide polymorphisms on H-HTN risk. Methods. Three investigators independently retrieved relevant studies in PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang Database, and China Biomedical Literature Database (CBM). A fixed or random effects model was selected to calculate pooled odds ratio (OR) and 95% confidence intervals (CIs). A network meta-analysis of diagnostic test and Thakkinstian’s algorithm were used to select the most appropriate genetic model, along with false-positive report probability (FPRP) for noteworthy associations. All data were processed using Stata 15.0 and Meta-Disc. Results. A total of 14 studies involving 1759 cases and 1581 controls for MTHFR were included in our meta-analysis. In a direct meta-analysis, we found that MTHFR C667T rs1801133 significantly increased the risk of H-HTN susceptibility except for an overdominant model. However, MTHFR A1298C rs1801131 polymorphism had no significant correlation with H-HTN risk. Besides, MTHFR C667T rs1801133 is a potential diagnostic biomarker for estimating H-HTN risk. The results indicated that the dominant model was an optimal diagnosis model for excluding diseases, which could reduce a missed diagnosis rate and further improve the accuracy of disease diagnosis. Conclusion. The present result suggests that MTHFR C667T rs1801133 polymorphism is associated with H-HTN risk and may act as a promising predictive biomarker for H-HTN risk. However, further well-designed studies are warranted to confirm these results.

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Prevalence of hyperhomocysteinemia and its associated factors in patients with primary hypertension in Chinese urban communities: A cross-sectional study from Nanjing

Cited by 20 publications

References 35 publications

Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China

Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China

Exploration of the risk factors of essential hypertension with hyperhomocysteinemia: A hospital-based study and nomogram analysis

Association of MTHFR Polymorphisms with H-Type Hypertension: A Systemic Review and Network Meta-Analysis of Diagnostic Test Accuracy

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