Identification of a peripheral blood long non-coding RNA (Upperhand) as a potential diagnostic marker of coronary artery disease

Abstract

The expression level of Upperhand in peripheral blood of CAD patients is significantly higher than in control individuals, and is correlated with severity of CAD. Upperhand is a potential diagnostic biomarker of CAD, and when combined with TCONS_00029157, diagnostic value slightly increased.

Plasma Exosomal S1PR5 and CARNS1 as Potential Non-invasive Screening Biomarkers of Coronary Heart Disease

“…However, S1PR5 and CARNS1 tests are easy to perform, with no radiation exposure or risk of contrast allergy. Moreover, S1PR5 and CARNS1 has better diagnostic value than other selected CHD biomarkers, such as has-circ-0124644, has-circ-0001879, has-circ-0004104, hsa-miR-584-5p, miR-1, miR-133, and TCONS-00029157 5 ( 14 – 17 ).…”

Circulating lncRNA IFNG‐AS1 expression correlates with increased disease risk, higher disease severity and elevated inflammation in patients with coronary artery disease

“…Long non‐coding RNAs (lncRNA) are a class of RNAs that are more than 200 nucleotides in length, while they do not encode protein functions . In recent years, studies illustrate that lncRNAs function in various aspects of cell biology, whose potential role in various diseases etiologies including cardiovascular diseases is of great concern . lncRNA IFNG‐AS1 is reported to be an enhancer of inflammation in ulcerative colitis (UC); induction of lncRNA ANRIL prevents coronary atherosclerosis by regulating apoptosis in vascular endothelial cells and inflammatory factor expression; and lncRNA ITSN1 is found to be elevated in rheumatoid arthritis patients and correlated with C‐reactive protein level .…”