Association of maternal breast milk and serum levels of macronutrients, hormones, and maternal body composition with infant’s body weight

Khodabakhshi, Adeleh; Mehrad‐Majd, Hassan; Vahid, Farhad; Safarian, Mohammad

doi:10.1038/s41430-017-0022-9

Cited by 12 publications

(13 citation statements)

References 29 publications

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“…A nutrition specialist assessed the nutritional status on the basis of Patient Generated-Subjective Global Assessment (PG-SGA) which evaluates recent weight loss, patients' intake, nutrition related complications, physical performance, nutrition impact diseases, fever, corticosteroid usage, muscle and fat wasting and edema (Bauer et al, 2002). PG-SGA is validated in Persian (Khodabakhshi et al, 2018;Shahabbasi J et al, 2018). Assessing physical condition was by means of physical performance status and muscle strength (Flood et al, 2014;Russell, 2015).…”

Section: Methodsmentioning

confidence: 99%

Nutritional Status in Patients with Esophageal Cancer Receiving Chemoradiation and Assessing the Efficacy of Usual Care for Nutritional Managements

Movahed

Norouzy

Ghanbari-Motlagh

et al. 2020

Asian Pac J Cancer Prev

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Background: Malnutrition is prevalent in esophageal cancer patients which affects cancer prognosis. The purpose of this study was a comprehensive assessment of nutritional status during Chemoradiation (CRT). Methods: Newly diagnosed adults with esophageal cancer were recruited for this study. Patient-Generated-Subjective Global Assessment (PG-SGA), anthropometric indices, body composition, dietary intake, laboratory tests, and nutritional-related complications were assessed before, after, and 4 to 6 weeks after CRT. Results: Seventy-one cases were enrolled. The mean age was 66.8±12 years. Patients' mean weight loss was 2.42±2.4 kilograms during treatment. A significant reduction observed in mean MUAC (26.68±4.9 vs. 25.42±5.1 cm), fat mass percentage (24.11±11.8 vs. 22.8±12.5), fat free mass index (16.87±2.4 vs. 16.47±2.6 kg/m 2 ) and hand grip strength (43.2±19 vs. 36.1±20 kg) during CRT (all p-values <0.0001). We had also a non-significant change in mean energy intake (19.5±11 vs. 18.3±11 kcal/kgw. day) and protein intake (0.56±0.4 vs. 0.66±0.5 g/kgw.day) during CRT. In our assessment before, immediately after and 4-6 weeks following CRT, we recorded energy intake insufficiency in 55.7%, 58.7% and 27.3% and protein intake inadequacy in 89.8%, 89.1% and 72.7% of cases, respectively. The most common complications were dysphagia (56.7%), anorexia (25%), and constipation (47.9%) at admission. Dysphagia improved in some cases (42%), but anorexia (35%), early satiety (25%), Esophagitis (25%), dysosmia (21%) and dysgeusia (17%) were increased as CRT complication. yet, 25% of patients had dysphagia and 34.4% had constipation 4-6 weeks after CRT. The twelve-months mortality was significantly associated with lower BMI after CRT, primary PG-SGA score, weight loss, BMI<18.5, MUAC, physical performance, living in rural or urban areas, addiction. Conclusion: Our study demonstrated a high prevalence of malnutrition among esophageal cancer patients which worsened during Chemoradiotherapy. Our findings warrant early screening and monitoring of nutritional status and effective nutritional interventions with symptoms management during treatment in these patients.

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Section: Methodsmentioning

confidence: 99%

Nutritional Status in Patients with Esophageal Cancer Receiving Chemoradiation and Assessing the Efficacy of Usual Care for Nutritional Managements

Movahed

Norouzy

Ghanbari-Motlagh

et al. 2020

Asian Pac J Cancer Prev

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“…Recently published studies have reported changes to a number of hormones, specifically leptin and insulin, in BM from obese compared with normal weight mothers ( Kugananthan et al, 2017 ; Lemas et al, 2016 ; Ley et al, 2012 ). Others have identified associations with adipokine levels in BM and infant growth ( Çatli, Olgaç Dündar & Dündar, 2014 ; Chan et al, 2017 ; Fields, Schneider & Pavela, 2016 ; Khodabakhshi et al, 2017 ; Savino et al, 2002 ). Due to the permeability of the digestive tract in early infancy non-nutritive bioactive factors, such as adipokines, can be transferred to the infant’s circulation ( Sanchez et al, 2005 ; Shehadeh, Sukhotnik & Shamir, 2006 ), where they are positioned to influence infant physiology.…”

Section: Introductionmentioning

confidence: 99%

The adipokine C1q TNF related protein 3 (CTRP3) is elevated in the breast milk of obese mothers

Kwon

Cress

Clark

et al. 2018

PeerJ

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BackgroundC1q TNF related protein 3 (CTRP3) is a relatively novel hormonal factor primarily derived from adipose tissue and has anti-diabetic properties. To determine if CTRP3 could play a role in early childhood development, the purpose of this study was to establish the presence of CTRP3 in breast milk (BM) and to determine whether CTRP3 levels were correlated with pregravid obesity status of the mother.MethodsBreast milk was collected from breast-feeding mothers who had a pregravid body mass index (BMI) classification of normal weight (BMI 18–25 kg/m2, n = 23) or obese (BMI > 30 kg/m2, n = 14). Immunoprecipitation followed by immunoblot analysis confirmed the presence of CTRP3 in BM. The concentration of CTRP3 in BM samples was determined by ELISA. Additional bioactive components were also measured by commercially available assays: ghrelin, insulin, leptin, adiponectin, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and glucose. Bioactive components in normal weight and obese mothers were compared using unpaired t-test (parametric) and Mann–Whitney U-test (non-parametric), as appropriate.ResultsThe primary findings of this study are that the adipokine CTRP3 is present in BM and CTRP3 levels are increased with pregravid obesity. Additionally, this study independently confirmed previous work that BM from obese mothers has a higher concentration of insulin and leptin. Further, no differences were observed in BM between obese and normal weight mothers in ghrelin, adiponectin, IL-6, TNF-α, or glucose levels.ConclusionThis study identified a novel factor in BM, CTRP3, and showed that BM CTRP3 levels higher in obese mothers. Because of the purported insulin sensitizing effect of CTRP3, it is possible that the elevated levels of CTRP3 in the BM of obese mothers may offset negative effects of elevated leptin and insulin levels in the BM of obese mothers. Future studies will need to be conducted to determine the relevance of CTRP3 in BM and to examine the presence of other adipose tissue-derived hormonal factors.

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“…After studying the titles and abstracts of the collected articles, 29 full-texts were assessed and 23 articles were excluded from the study. Six articles met the criteria for meta-analysis (19,20,(23)(24)(25)(26). The excluded articles from the study (n=23) included the following: 5 articles presented the effect of breast milk ghrelin on growth in infants (6,18,21,22,27), 8 articles expressed no correlation between infants' serum ghrelin and growth (2, 17, 28-33), 3 articles were of descriptive nature (34-36), and 6 articles had an intervention group (37)(38)(39)(40)(41)(42).…”

Section: Resultsmentioning

confidence: 99%

“…The characteristics of the selected studies are listed in Table 2. This study included three cohort (20,23,26) articles and three cross-sectional (19,24,25) studies on infants aged <2 years for meta-analysis. Immunoassay methods were used for measuring ghrelin in the serum of infants.…”

Section: Resultsmentioning

confidence: 99%

Relationship Between Breast Milk Ghrelin and Infants’ Serum Ghrelin and Growth in Breastfeeding Infants: A Systematic Review and Meta-Analysis

et al. 2020

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Background: There is positive correlation between infant serum ghrelin and the growth of infants in breastfed infants. Objectives: The present study aimed to evaluate of the relationship between breast milk ghrelin and serum ghrelin and growth in breast-milk-fed infants by systematic review and meta-analysis approaches. Methods: Electronic resources used in the current search were Scopus, Cochrane Library, Science Direct, PubMed, and EMBASE. The English language full-text articles and abstracts published from 1999 to July 2019 were collected. Only the articles that explored infants under two years of age and receiving breast milk exclusively were reviewed. Papers related to healthy mothers and infants were entered in this study. The results of 6 papers regarding the effect of serum ghrelin on the growth of infants, i.e., evaluated by meta-analysis using Stata software. The data addressing the effect of breast milk ghrelin on growth were reported by a systematic review manner; three articles were found in this area. We used Preferred Reporting Items for systematic reviews and meta-analyses (prisma) checklist for performing this study. Results: In this study, the association of infants' serum ghrelin with infants' growth was evaluated by meta-analysis. Newcastle-Ottawa Scale (NOS) value was ≥7scores for the 6 explored meta-analysis articles. The present meta-analysis research suggested a positive and significant correlation between infant serum ghrelin and the growth of infants (r=0.163). Conclusions: The random-effect model data demonstrated a positive and significant correlation between infant serum ghrelin and the growth of infants. However, in the study of the effect of breast milk ghrelin on infants' growth, the number of articles was limited and contradictory results were reported. Accordingly, no general conclusion was reached.

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Association of maternal breast milk and serum levels of macronutrients, hormones, and maternal body composition with infant’s body weight

Abstract: Our findings provide a positive association of maternal weight, daily breast milk intake, EGF, and ghrelin with infant's body weight.

Cited by 12 publications

References 29 publications

Nutritional Status in Patients with Esophageal Cancer Receiving Chemoradiation and Assessing the Efficacy of Usual Care for Nutritional Managements

Nutritional Status in Patients with Esophageal Cancer Receiving Chemoradiation and Assessing the Efficacy of Usual Care for Nutritional Managements

The adipokine C1q TNF related protein 3 (CTRP3) is elevated in the breast milk of obese mothers

Relationship Between Breast Milk Ghrelin and Infants’ Serum Ghrelin and Growth in Breastfeeding Infants: A Systematic Review and Meta-Analysis

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