Reply to Areta et al.: Time to withdraw and let the myth rest

O USO DE RECURSOS ERGOGÊNICOS NUTRICIONAIS ENTRE ATLETAS OU DESPORTISTAS COM ÊNFASE EM SEU EFEITO PLACEBO: Uma revisão integrativa

“…And argue that the results that show no improvement in performance may be related to lack of standardization among studies, such as diet, age, sex, power supply after exercise, intensity of exercise, physical conditioning and habituation, which can be reached with a daily intake of 100mg of caffeine (2.5 cups of coffee). However Gualano et al 21 have shown that the effects on acute supplementation of caffeine were not influenced by the level of regular consumption of this substance. Determine whether the ingestion of whey protein increases the balance of the liquid protein and recovery of exercise performance during the night (10:00) and 12:00 am recovery after resistance exercise in trained men.…”

Reprogramming alternative macrophage polarization by GATM-mediated endogenous creatine synthesis: A potential target for HDM-induced asthma treatment

“…GATM is the key rate-limiting step that catalyzes endogenous creatine biosynthesis: the transfer of amino groups from arginine to glycine to form ornithine and guanidinoacetic acid directly promotes creatine biosynthesis, w h i c h i s s u p p l e m e n t e d b y c y t o p l a s m i c A T P v i a phosphocreatine shuttling while consuming mitochondrial ATP (37). In hereditary diseases where creatine synthesis is impaired, creatine has a disease-modifying capacity, including mental fatigue (50), sleep deprivation (51, 52), environmental hypoxia such as in mountain climbing and advanced age (53-55), but except people with kidney disease (56). Recent studies have found that exogenous creatine aggravates the inflammatory response in asthma (35), but the mechanism had not been elucidated.…”