Predictors of death in infants with probable serious bacterial infection

Singh, Prashant; Arora, Ananya; Strand, Tor A.; Sommerfelt, Halvor; Lodha, Rakesh; Kabra, Sushil Kumar; Aneja, Satinder; Natchu, Uma Chandra Mouli; Chandra, Jagdish; Rath, Bimbadhar; Sharma, Vinod; Kumari, Mohini; Saini, Sharanjot; Bhatnagar, Shinjini; Wadhwa, Nitya

doi:10.1038/pr.2017.299

Cited by 7 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding corresponds to the 7-day findings of Dire Dawa (23) and Central Gondar (16). This is also comparable to the findings of earlier studies conducted in Uganda (31) and India (32), which reported median times to recovery for septic neonates of 4.5 and 5.5 days, respectively. These studies shared certain characteristics with the current investigation, such as being conducted on newborns admitted to public hospitals, having a neonate age limit of 0-28 days, having similar sample sizes, and considering clinically confirmed cases.…”

Section: Discussionsupporting

confidence: 90%

Time to recovery from neonatal sepsis and its determinants among neonates admitted in Woldia comprehensive specialized hospital, Northeast Ethiopia: a retrospective cohort study

Ambaye,

Yimer,

Mislu

et al. 2024

Front. Pediatr.

View full text Add to dashboard Cite

BackgroundNeonatal sepsis is the most serious problem in neonates. It is the leading cause of neonatal death in developing countries, particularly in sub-Saharan Africa. The Ethiopian 2016 Demographic Health Survey report revealed that a high number of neonatal deaths are associated with neonatal sepsis. However, limited studies are available on exposure and time to recovery inferences in Ethiopia. Therefore, this study aimed to assess the time to recovery from neonatal sepsis and its determinants among neonates admitted to Woldia Comprehensive Specialized Hospital (WCSH), Northeast Ethiopia.MethodsA retrospective cohort study was conducted, including 351 neonates, using systematic random sampling at WCSH from 7 to 30 March 2023. The data were entered into Epi data version 4.6 and exported to STATA 14 for analysis. Cox regression was used to identify the determinants of time to recovery from neonatal sepsis, and a variable with a p-value of less than 0.05, was used to declare significant association at a 95% confidence interval.ResultAmong 351 neonates with sepsis, 276 (78.63%) recovered, and the median time to recovery was 6 days. Induced labor (AHR = 0.54, 95% CI: 0.369, 0.78) and resuscitation at birth (AHR = 0.7, 95% CI: 0.51, 0.974) were significantly associated with the recovery time of neonatal sepsis.Conclusions and recommendationThe time to recovery from neonatal sepsis is comparable to previous studies' results. The 25th and 75th percentiles were 4 and 8 days, respectively. Health professionals working in the NICU need to pay special attention to neonates born from mothers who had induced labor and those who were resuscitated at birth.

show abstract

Section: Discussionsupporting

confidence: 90%

Time to recovery from neonatal sepsis and its determinants among neonates admitted in Woldia comprehensive specialized hospital, Northeast Ethiopia: a retrospective cohort study

Ambaye,

Yimer,

Mislu

et al. 2024

Front. Pediatr.

View full text Add to dashboard Cite

show abstract

“…It is usually used as a useful predictor for infection, or even death, in infants with a probable serious bacterial infection. 26,27 Our results showed that either CRP or WBC could discriminate infants with CAP, but the sensitivities of these two markers for the diagnosis of CAP were poor, although CRP showed higher specificity. The high specificity for CRP may be due to the presence of upregulated serum Pin1.…”

Section: Discussionmentioning

confidence: 67%

Serum peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 in combination with C-reactive protein and white blood cell as novel predictors for infants with community-acquired pneumonia

Xue

Liu

et al. 2020

Eur J Inflamm

View full text Add to dashboard Cite

The aim of this study was to investigate the predictive value of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) with C-reactive protein (CRP) and white blood cell (WBC) count for community-acquired pneumonia (CAP) in infants. A total of 84 hospitalized infants with CAP and 69 healthy infants were included in this study. The clinical manifestations and laboratory assay results of infants were recorded. Serum Pin1 level was estimated by enzyme-linked immunosorbent assay. The median serum Pin1 concentration in infants with CAP was significantly higher than that in controls (1.44 vs. 0.21 ng/mL, P < 0.0001). Receiver operating characteristic (ROC) curve analysis showed that the area under the ROC curve (AUC) of the combination Pin1, CRP and WBC (Pin1 + CRP + WBC, 0.943) was higher than Pin1, CRP, WBC alone or the combination of Pin1 and CRP ( P < 0.05). The sensitivity of Pin1 + CRP + WBC (94.0%) was higher than that of Pin1, CRP, WBC alone, or any two combined ( P < 0.05). Pin1 + CRP + WBC also had a high negative predictive value (91.4%). Moreover, serum Pin1 alone had a high specificity (97.0%) and excellent positive predictive value (96.6%) for infants with CAP, which were higher than WBC, Pin1 and WBC in combination, CRP and WBC in combination, and Pin1 + CRP + WBC ( P < 0.05). Therefore, serum Pin 1 was highly expressed in infants with CAP and can singly or in combination with CRP and WBC represent promising novel predictors for infants with CAP.

show abstract

“…Several, low-risk criteria and clinical prediction models have been developed to screen for serious bacterial infections in febrile young infants [10,11]. Although these diagnostic tools have expedited clinicians' decision making and helped to improve the use of resources in pediatric acute care [12,13], clinicians may still misdiagnose serious viral infections if they rely only on methods used to diagnose bacterial infections [14,15].…”

Section: Introductionmentioning

confidence: 99%

Limited Utility of SIRS Criteria for Identifying Serious Infections in Febrile Young Infants

et al. 2021

View full text Add to dashboard Cite

(1) Background: Young infants have a high risk of serious infection. The Systematic Inflammatory Response Syndrome (SIRS) criteria can be useful to identify both serious bacterial and viral infections. The aims of this study were to evaluate the diagnostic performance of the SIRS criteria for identifying serious infections in febrile young infants and to identify potential clinical predictors of such infections. (2) Methods: We conducted this prospective cohort study including febrile young infants (aged < 90 days) seen at the emergency department with a body temperature of 38.0 °C or higher. We calculated the diagnostic performance parameters and conducted the logistic regression analysis to identify the predictors of serious infection. (3) Results: Of 311 enrolled patients, 36.7% (n = 114) met the SIRS criteria and 28.6% (n = 89) had a serious infection. The sensitivity, specificity, positive predictive value, and positive likelihood ratio of the SIRS criteria for serious infection was 45.9%, 69.4%, 43.5%, 71.4%, 1.5, and 0.8, respectively. Logistic regression showed that male gender, body temperature ≥ 38.5 °C, heart rate ≥ 178 bpm, and age ≤ 50 days were significant predictors. (4) Conclusions: The performance of the SIRS criteria for predicting serious infections among febrile young infants was poor.

show abstract

Predictors of death in infants with probable serious bacterial infection

Cited by 7 publications

References 33 publications

Time to recovery from neonatal sepsis and its determinants among neonates admitted in Woldia comprehensive specialized hospital, Northeast Ethiopia: a retrospective cohort study

Time to recovery from neonatal sepsis and its determinants among neonates admitted in Woldia comprehensive specialized hospital, Northeast Ethiopia: a retrospective cohort study

Serum peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 in combination with C-reactive protein and white blood cell as novel predictors for infants with community-acquired pneumonia

Limited Utility of SIRS Criteria for Identifying Serious Infections in Febrile Young Infants

Contact Info

Product

Resources

About