Acquisition, Persistence, and Clearance of Human Papillomavirus Infection Among Male Virgins Residing in Brazil, Mexico, and the United States

Liu, Zhiyue; Nyitray, Alan G.; Hwang, Lu-Yu; Swartz, Michael D.; Abrahamsen, Martha; Lazcano‐Ponce, Eduardo; Villa, Luisa L.; Giuliano, Anna R.

doi:10.1093/infdis/jix588

Cited by 21 publications

(19 citation statements)

References 24 publications

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“…This notion is supported by data describing horizontal HPV transmission from HPV-positive mothers to their sexually inactive children [ 57 , 58 ] and by data describing the incidence rates of HPV infection among male virgins who did, and those who did not, initiate sexual activity during a follow-up of period of 80 months. The results were 26.2 and 16.6 cases/1000 person-months, respectively [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

No association between HPV-status in tonsillar tissue and sexual behavior of the patients in a northern German population - Critical view of the link between HPV natural history and HPV-driven carcinogenesis

Quabius

Fazel

Knieling

et al. 2020

Papillomavirus Research

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HPV-infection in patients with HNSCC is reportedly correlated with sexual behavior, age, and tobacco/alcohol-consumption. HPV-infections of the oral cavity are regarded as sexually transmitted. Comparable data of patient populations outside the U.S. are sparse or missing. Questionnaires regarding sexual behavior, education tobacco- and alcohol-consumption, were given to 28 patients with tonsillar hyperplasia (H) and 128 patients with tonsillar carcinomas (CA), all with tissue-typed HPV-DNA-status performing PCR. Answers were correlated among groups and HPV-status. 106 questionnaires were analyzed. Comparisons between H- (n = 25) and CA- (n = 81) patients showed that CA-patients were older (61.1yrs ± 9.3) than H-patients (45.2yrs ± 11.9; p < 0.0001; Student's t-test); had a lower educational level (p = 0.0095); and lower number of sexual partners (p = 0.0222; Fisher's exact test). All groups showed a significant correlation between smoking and lack of HPV-DNA-positivity (p = 0.001). Further Fisher's exact tests and logistic regression analysis revealed in all 106 patients no significant correlations between tissue-HPV-status and the analyzed parameters. Despite the limited sample size, we were able to confirm the established correlation between smoking and tissue-HPV-status. The correlation between sexual behavior and HPV-infection was not confirmed. No consensus exists in the literature about the latter. Our data does not support the strict classification of oral HPV-infections and HPV-driven HNSCCs as STDs.

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Section: Discussionmentioning

confidence: 99%

No association between HPV-status in tonsillar tissue and sexual behavior of the patients in a northern German population - Critical view of the link between HPV natural history and HPV-driven carcinogenesis

Quabius

Fazel

Knieling

et al. 2020

Papillomavirus Research

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“…Among MSM, Szwarcwald et al 29 conducted a large study but was limited to Brazilian military conscripts, while Ferreira et al 30 analysed a sample of MSM drug users but did not focus on HPV prevalence. The HPV in Men (HIM) study was designed to assess HPV type distribution but only among men residing in São Paulo 31…”

Section: Discussionmentioning

confidence: 99%

Evaluating sexual health in sex workers and men who have sex with men: the SMESH cross-sectional protocol study

et al. 2019

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IntroductionHuman papillomavirus (HPV) infection is transmitted through skin-to-skin contact, and vaginal and anal sex are the most common transmission routes. Sex workers and men who have sex with men (MSM) are more exposed to the virus, and therefore, a higher frequency of this infection would be expected. The prevalence of HPV infection types and the forms and factors of transmission must be investigated to control infection-related outcomes. This protocol study will be the first nationwide study with a uniform methodology to evaluate HPV prevalence of and infection types among sex workers and MSM in Brazil.Methods and analysisThis multicentre cross-sectional study will be conducted with a respondent-driven sampling method to recruit 1174 sex workers and 1198 MSM from all regions of Brazil. The study will consist of preliminary interviews to verify the eligibility criteria and characterise the network size as well as a second questionnaire to obtain sociodemographic, behavioural and sexual information. Specimens from the oral cavity and anal and cervical or penile/scrotal sites will be collected. All HPV samples will be processed in a certified central laboratory. Other sexually transmitted infections will be evaluated by interview and by rapid testing for HIV and syphilis. Strict quality control will be conducted using different procedures, including the training and certification of the health professionals responsible for acquiring data and monitoring visits.Ethics and disseminationThe project was approved by the research ethics committee of the main institution and the corresponding ethics committees of the recruitment sites. Due to the literature gap on the sexual health of sex workers and MSM and the intense stigma surrounding these populations, a critical analysis of the study results will contribute to epidemiological knowledge and will be useful for the development of strategies against virus morbidities.

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“…Table 3 shows the approach the authors used to estimate IR in their study. Of the 57 articles, 22 [[32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53]], one [22], and two [23,25] used approaches A, B and C respectively, and six [[54], [55], [56], [57], [58], [59]], one [21], and five [24,26,[28], [29], [30]] articles used approaches D, E and F respectively. One study used both approaches B and E [19] and two studies used both C and F [4,20].…”

Section: Resultsmentioning

confidence: 99%

Estimating incidence rates of grouped HPV types: A systematic review and comparison of the impact of different epidemiological assumptions

Jongen

Santen

Alberts

et al. 2019

Papillomavirus Research

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BackgroundSome studies on human papillomavirus (HPV) provide not only type-specific incidence rates (IR), but also IRs of HPV groupings (e.g. the nonavalent grouping). We made an inventory of the different approaches used to calculate such IRs and assessed their impact on the estimated IRs of HPV groupings.MethodsWe performed a systematic review assessing all approaches used in literature to estimate IRs. Subsequently we applied these approaches to data of a Dutch cohort study on HPV in men who have sex with men (H2M). IRs were estimated for six different HPV groupings.ResultsThe systematic review yielded six different approaches (A-F) for estimating the IRs, varying in exclusion criteria at baseline, and the definitions of an incident event and person-time. Applying these approaches to the H2M dataset (n = 749), we found differences in the number of participants at risk, number of incidents events, person-time, and IR. For example, for the nonavalent grouping, depending on the approach chosen, the IR varied between 3.09 and 6.54 per 100 person-months.ConclusionIn published studies different epidemiological assumptions are used to estimate IRs of grouped HPV types, leading to widely differing estimates of IRs. IRs between different studies may therefore not be comparable.

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Acquisition, Persistence, and Clearance of Human Papillomavirus Infection Among Male Virgins Residing in Brazil, Mexico, and the United States

Abstract: Virgins who did not initiate sex during follow-up still acquired HPV infection, possibly through nonpenetrative sexual contact. Further prospective cohort studies are needed to better understand factors associated with HPV acquisition and clearance in male virgins and recent nonvirgins.

Cited by 21 publications

References 24 publications

No association between HPV-status in tonsillar tissue and sexual behavior of the patients in a northern German population - Critical view of the link between HPV natural history and HPV-driven carcinogenesis

No association between HPV-status in tonsillar tissue and sexual behavior of the patients in a northern German population - Critical view of the link between HPV natural history and HPV-driven carcinogenesis

Evaluating sexual health in sex workers and men who have sex with men: the SMESH cross-sectional protocol study

Estimating incidence rates of grouped HPV types: A systematic review and comparison of the impact of different epidemiological assumptions

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