Telomere tracking from birth to adulthood and residential traffic exposure

Bijnens, Esmée; Zeegers, Maurice P.; Derom, Cathérine; Martens, Dries S.; Gielen, Marij; Hageman, Geja J.; Plusquin, Michelle; Thiery, Evert; Vlietinck, Robert; Nawrot, Tim S.

doi:10.1186/s12916-017-0964-8

Cited by 53 publications

(54 citation statements)

References 58 publications

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“…34 Further, the authors found associations between residential traffic exposure at birth and accelerated telomere shortening in the first two decades of life. 34 There have been several longitudinal studies of the influence of traffic-related air pollution on lung function in early development versus later in life. 35,36 For example, a study of 2307 children from the Oslo Birth Cohort found that increased early life and lifetime exposure to PM 10 and NO 2 were associated with reduced expiratory flow measurements, with exposure in the first year of life having slightly stronger effects.…”

Section: Discussionmentioning

confidence: 95%

“…A longitudinal twin study that measured telomere length in prenatal placenta and buccal cells in young adulthood found inverse associations between traffic‐related air pollution and telomere length . Interestingly, the authors found that residential traffic exposure at the birth address was significantly and inversely associated with telomere length ranking between birth and adulthood; however, residential traffic exposure in adulthood was not associated with telomere length . Further, the authors found associations between residential traffic exposure at birth and accelerated telomere shortening in the first two decades of life .…”

Section: Discussionmentioning

confidence: 96%

“…Traffic‐related air pollution contains certain common toxic constituents as coal emissions. A longitudinal twin study that measured telomere length in prenatal placenta and buccal cells in young adulthood found inverse associations between traffic‐related air pollution and telomere length . Interestingly, the authors found that residential traffic exposure at the birth address was significantly and inversely associated with telomere length ranking between birth and adulthood; however, residential traffic exposure in adulthood was not associated with telomere length .…”

Section: Discussionmentioning

confidence: 98%

“…Interestingly, the authors found that residential traffic exposure at the birth address was significantly and inversely associated with telomere length ranking between birth and adulthood; however, residential traffic exposure in adulthood was not associated with telomere length . Further, the authors found associations between residential traffic exposure at birth and accelerated telomere shortening in the first two decades of life . There have been several longitudinal studies of the influence of traffic‐related air pollution on lung function in early development versus later in life .…”

Section: Discussionmentioning

confidence: 98%

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Lung cancer risk by geologic coal deposits: A case–control study of female never‐smokers from Xuanwei and Fuyuan, China

Wong

Downward

et al. 2019

Intl Journal of Cancer

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Coal types vary around the world because of geochemical differences in their source deposits; however, the influence of coal emissions from different deposits on human health remains unexplored. To address this issue, we conducted the first study of the relationship between coal use from various deposits and lung cancer risk in Xuanwei and Fuyuan, counties in China where lung cancer rates are among the highest in the world among female never‐smokers due to use of bituminous (“smoky”) coal for heating and cooking. We conducted a population‐based case–control study of 1031 lung cancer cases and 493 controls among never‐smoking women in Xuanwei and Fuyuan. Logistic regression models were used to estimate associations between coal use from various deposits across the lifecourse and lung cancer risk. There was substantial heterogeneity in risks by coal deposit (p = 7.8E‐05). Compared to non‐smoky coal users, risks by smoky coal deposit ranged from OR = 7.49 (95% CI: 3.43–16.38) to OR = 33.40 (95% CI: 13.07–85.34). Further, women born into homes that used smoky coal and subsequently changed to non‐smoky coal had a higher risk (OR = 10.83 (95% CI: 4.61–25.46)) than women born into homes that used non‐smoky coal and changed to smoky coal (OR = 4.74 (95% CI: 2.03–11.04, pdifference = 0.04)). Our study demonstrates that various sources of coal have considerably different impact on lung cancer in this population and suggests that early‐life exposure to carcinogenic emissions may exert substantial influence on health risks later in life. These factors should be considered when evaluating the health risks posed by exposure to coal combustion emissions.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

See 2 more Smart Citations

Lung cancer risk by geologic coal deposits: A case–control study of female never‐smokers from Xuanwei and Fuyuan, China

Wong

Downward

et al. 2019

Intl Journal of Cancer

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“…80 Interestingly, the association between the distance that pregnant mothers lived to a major road and TL persisted when telomeres in buccal cells were evaluated from the same individuals but now during young adulthood (mean age (SD) of 22.6 (3.1) years). 81 An Italian study 82 Evidence of occupational and environmental exposures (based on the home address) to chemicals and air pollutants in relationship with TL have been documented before. 16,84 However, in this review we add newly identified studies that extend the evidence of the association between TL and particulate matter exposure as previously reviewed by Martens and Nawrot.…”

Section: Residential Landscape and Telomere Lengthmentioning

confidence: 99%

Ageing at the level of telomeres in association to residential landscape and air pollution at home and work: a review of the current evidence

Martens

Nawrot

2018

Toxicology Letters

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Studies suggest that leukocyte telomere length is an index of systemic ageing. Here, we discuss telomere length as a marker of biological ageing in relation to residential landscape (greenness), residential air pollution and work-related exposures. Telomere lengths are memories of cumulative oxidative and inflammatory stress, and show to have inverse associations with the risk of non-communicable diseases. For this reason, telomeres are considered as markers of biological ageing. Studies at birth, in children, young adulthood, and elderly show that residential green space, lower traffic exposure and long-term lower exposure to particulate air pollution are associated with longer telomeres. Work-related exposures including exposure to toxic metals, polycyclic aromatic hydrocarbons and particulate matter are associated with shorter telomeres for a given age. In contrast to chronic exposures, evidence is present of the observation that recent exposure is associated with longer telomeres. Our overview shows that the magnitude of residential and work-related environmental factors on telomere length are often as important as many classical lifestyle factors.

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Association of Parental Socioeconomic Status and Newborn Telomere Length

et al. 2020

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IMPORTANCE Low socioeconomic status is associated with higher all-cause mortality and risks for aging-related diseases. Biological aging is a potential process underlying health conditions related to social disadvantages, which may be present from birth onward. OBJECTIVE To evaluate the association of parental socioeconomic status with telomere length (TL) at birth, a marker of biological aging. DESIGN, SETTING, AND PARTICIPANTSThis prospective birth cohort study was conducted among 1504 mother-newborn pairs in Belgium recruited between February 1, 2010, and July 1, 2017. EXPOSURES Parental socioeconomic measures, including maternal educational level, occupation, paternal educational level, and neighborhood income based on median annual household income. MAIN OUTCOMES AND MEASURES Mean relative TL was measured in cord blood and placental tissue. By constructing a principal component, an integrative socioeconomic measure was derived that integrates parental socioeconomic status and neighborhood income. Multivariable adjusted regression analyses were performed to associate the integrative socioeconomic measure and TL at birth. RESULTSIn 1026 newborns (517 boys; mean [SD] gestational age, 39.2 [1.4] weeks), a higher socioeconomic status was associated with longer cord blood TL and placental TL. Each unit increment in the integrative socioeconomic status measure was associated with 2.1% (95% CI, 0.9%-3.4%; P < .001) longer cord blood TL in boys, while no association was observed for girls (0.5% longer cord blood TL; 95% CI, −0.9% to 1.8%; P = .50). The sex-specific socioeconomic status interaction revealed a stronger association in boys compared with newborn girls (1.6%; 95% CI, 0.02%-3.3%; P = .047 for interaction). In placental tissue, higher socioeconomic status was associated with 1.8% (95% CI, 0.3%-3.3%; P = .02) longer TL in newborn boys but not in girls (0.4% longer TL; 95% CI, −1.2% to 2.0%; P = .63). For placental tissue, no sex and socioeconomic status interaction on TL was observed (1.4%; 95% CI, −0.5% to 3.4%; P = .16 for interaction). CONCLUSIONS AND RELEVANCEThis study suggests that parental socioeconomic status is associated with newborn TL, especially in boys. The results indicate that familial social economic factors are associated with the potential cellular longevity of the next generation, with a potential higher transgenerational vulnerability for newborn boys.

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Telomere tracking from birth to adulthood and residential traffic exposure

Cited by 53 publications

References 58 publications

Lung cancer risk by geologic coal deposits: A case–control study of female never‐smokers from Xuanwei and Fuyuan, China

Lung cancer risk by geologic coal deposits: A case–control study of female never‐smokers from Xuanwei and Fuyuan, China

Ageing at the level of telomeres in association to residential landscape and air pollution at home and work: a review of the current evidence

Association of Parental Socioeconomic Status and Newborn Telomere Length

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