Fatty Acids in Nephrotic Syndrome and Chronic Kidney Disease

Turolo, Stefano; Edefonti, Alberto; Syrén, Marie Louise; Marangoni, Franca; Morello, William; Agostoni, Carlo; Montini, Giovanni

doi:10.1053/j.jrn.2017.08.005

Cited by 22 publications

(18 citation statements)

References 101 publications

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“…8,9 Yet, during the disease progression, alterations of fatty acid metabolism and composition might occur, leading to a cascade of adverse events in the body. 10,11 In contrast to PUFAs, MUFAs do not belong to essential fatty acids, as they can be synthetized by an endogenous enzyme, stearoyl -coenzyme A desaturase -1 (SCD1). 12 In some countries, consumption of MUFAs accounts for at least one--third of the total fatty acid intake.…”

Section: Original Articlementioning

confidence: 99%

Potential contribution of monounsaturated fatty acids to cardiovascular risk in chronic kidney disease

Mika¹,

Sikorska-Wiśniewska²,

Małgorzewicz³

et al. 2018

Polish Archives of Internal Medicine

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INTROduCTION Patients with chronic kidney disease (CKD) are particularly susceptible to cardiovascular disease (CVD). Increased synthesis of endogenous monounsaturated fatty acids (MUFAs) by stearoyl CoA desaturase 1 (SCD1) might predispose to cardiovascular complications. ObjECTIvEs The aim of this study was to examine the serum MUFA content in patients at subsequent stages of CKD, and to evaluate associations between MUFA content and SCD1 activity, patients' diet, and cardiovascular risk. PATIENTs ANd mEThOds Serum fatty acid composition was evaluated in 177 patients with subsequent stages of CKD (1-2, 3a, 3b, 4-5, hemodialysis, peritoneal dialysis, and after kidney transplantation), and in 30 healthy controls. Gas chromatography-mass spectrometry was used for the measurement. REsuLTs Serum MUFA content was shown to increase with subsequent stages of CKD and to be cor related with various risk factors of CVD, including serum triacylglycerols, HDL cholesterol (P <0.01), and highsensitivity Creactive protein (P <0.05). Moreover, also the prevalence of CVD was shown to increase with CKD progression. Estimated SCD1 activity was associated with serum MUFA content (P <0.01), but no association was found between dietary MUFA intake and serum MUFA levels. CONCLusIONs Our results indicate that the elevation of serum MUFA levels in CKD patients may con tribute to an increased risk of CVD during CKD progression, mainly due to increased endogenous MUFA synthesis by SCD1.

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Section: Original Articlementioning

confidence: 99%

Potential contribution of monounsaturated fatty acids to cardiovascular risk in chronic kidney disease

Mika¹,

Sikorska-Wiśniewska²,

Małgorzewicz³

et al. 2018

Polish Archives of Internal Medicine

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“…Significant modifications in the FA profile of circulating lipids have been observed in patients with CKD and nephrotic syndrome [ 54 ]. However, whether this condition is a consequence or a cause of the renal dysfunction is still a matter of debate.…”

Section: Fatty Acidsmentioning

confidence: 99%

Nutrients, Nutraceuticals, and Xenobiotics Affecting Renal Health

et al. 2018

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Chronic kidney disease (CKD) affects 8–16% of the population worldwide. In developed countries, the most important risk factors for CKD are diabetes, hypertension, and obesity, calling into question the importance of educating and acting on lifestyles and nutrition. A balanced diet and supplementation can indeed support the maintenance of a general health status, including preservation of renal function, and can help to manage and curb the main risk factors for renal damage. While the concept of protein and salt restriction in nephrology is historically acknowledged, the role of some nutrients in renal health and the importance of nutrition as a preventative measure for renal care are less known. In this narrative review, we provide an overview of the demonstrated and potential actions of some selected nutrients, nutraceuticals, and xenobiotics on renal health and function. The direct and indirect effects of fiber, protein, fatty acids, curcumin, steviol glycosides, green tea, coffee, nitrates, nitrites, and alcohol on kidney health are reviewed here. In view of functional and personalized nutrition, understanding the renal and systemic effects of dietary components is essential since many chronic conditions, including CKD, are related to systemic dysfunctions such as chronic low-grade inflammation.

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“…Significant modifications in the FA profile of circulating lipids have been observed in patients with CKD and nephrotic syndrome [55]. However, whether this condition is a consequence or a cause of the renal problem is still a matter of debate.…”

Section: Proteinsmentioning

confidence: 99%

“…Depending on the parental FA, the resulting metabolites can have different effects, acting in the vascular system as vasoconstrictors and dilators. The epoxyeicosatrienoic (EET) acids derived from the AA are a family of metabolites with important effects in the kidney [55]. They inhibit Na channels at the cortical collecting duct [77], maintain the glomerular permeability barrier to albumin [78], and also play a protective role against glomerular damage [79].…”

Section: Proteinsmentioning

confidence: 99%

Nutrients, Nutraceuticals and Xenobiotics Affecting Renal Health

Cosola

Sabatino

Bari

et al. 2018

Preprint

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Abstract:Chronic kidney disease (CKD) affects worldwide 8-16% of the population. In developed countries, the most important risk factors for CKD are diabetes, hypertension and obesity, calling into question the importance of educating and acting on lifestyles and nutrition. A balanced nutrition and supplementation can indeed support the maintenance of a general health status, including preservation of renal function, and help to manage and curb the main risk factors for renal damage. While the concepts of protein and salt restriction in nephrology are historically acknowledged, the role of some nutrients on renal health and the importance of nutrition as a preventative measure for renal care are less known.In this review, we provide an overview of the demonstrated and potential actions of some selected nutrients, nutraceuticals and xenobiotics on renal health and function. The effects on kidney of fibres, proteins, fatty acids, curcumin, steviol glycosides, green tea, coffee, nitrates, nitrites, and alcohol, both direct and indirect, in CKD and non-CKD condition, are reviewed here. In a view of a functional and personalized nutrition, understanding the renal and systemic effects of dietary components is essential since many chronic conditions and CKD are related to systemic dysfunctions such as chronic low-grade inflammation.

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Fatty Acids in Nephrotic Syndrome and Chronic Kidney Disease

Cited by 22 publications

References 101 publications

Potential contribution of monounsaturated fatty acids to cardiovascular risk in chronic kidney disease

Potential contribution of monounsaturated fatty acids to cardiovascular risk in chronic kidney disease

Nutrients, Nutraceuticals, and Xenobiotics Affecting Renal Health

Nutrients, Nutraceuticals and Xenobiotics Affecting Renal Health

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