Oxidative stress and DNA damage in the cord blood of preterm infants

Norishadkam, M; Andishmand, Soudeh; Reza, Javad Zavar; Sakhvidi, Mohammad Javad Zare; Hachesoo, Vida Rezae

doi:10.1016/j.mrgentox.2017.10.003

Cited by 20 publications

(18 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… ↑ 8-OHdG [13] 27/24 38.1 (37–41) 33.7 (30–36) Umbilical cord blood at birth NA ↑ plasma F2-isoprostane ↑ NPBI ↑ DCI ↑ placenta F2-isoprostane [15] 91/47 39.2 (36–42) 31.4 (23–36) Umbilical cord blood at birth 32 required assisted ventilation, 22 suffered from respiratory distress syndrome and 10 from perinatal hypoxia ↑ MDA [18] 29/31 39.4 (37.4–41.6) 31.7 (28.1–35.7) Umbilical cord blood at birth No SGA newborns. ↑ MDA adduct to hemoglobin No intensive care requirement and medical complications [25] 25/25 38.04 (36–42) 32.92 (28–35) Umbilical cord blood at birth No congenital malformations or asphyxia. = MDA = TAS = CAT Healthy nonsmokers’ mothers.…”

Section: Oxidative Stress In Preterm Newbornsmentioning

confidence: 99%

“…When compared to full-term birth, the antioxidant system after a PTB appears to be deficient. Indeed, at birth, superoxide dismutase (SOD) activity in both blood [14] , [25] and erythrocytes [19] , [26] , catalase (CAT) activity in blood [17] as well as cytosolic glutathione peroxidase (GPx) in erythrocytes [19] are lower in preterm than in full-term newborns. This indicates lower antioxidant enzymatic activity in the former ( Table 1 ).…”

Section: Oxidative Stress In Preterm Newbornsmentioning

confidence: 99%

See 1 more Smart Citation

Preterm birth and oxidative stress: Effects of acute physical exercise and hypoxia physiological responses

et al. 2018

View full text Add to dashboard Cite

Preterm birth is a global health issue that can induce lifelong medical sequela. Presently, at least one in ten newborns are born prematurely. At birth, preterm newborns exhibit higher levels of oxidative stress (OS) due to the inability to face the oxygen rich environment in which they are born into. Moreover, their immature respiratory, digestive, immune and antioxidant defense systems, as well as the potential numerous medical interventions following a preterm birth, such as oxygen resuscitation, nutrition, phototherapy and blood transfusion further contribute to high levels of OS. Although the acute effects seem well established, little is known regarding the long-term effects of preterm birth on OS. This matter is especially important given that chronically elevated OS levels may persist into adulthood and consequently contribute to the development of numerous non-communicable diseases observed in people born preterm such as diabetes, hypertension or lung disorders. The purpose of this review is to summarize the current knowledge regarding the consequences of preterm birth on OS levels from newborn to adulthood. In addition, the effects of physical activity and hypoxia, both known to disrupt redox balance, on OS modulation in preterm individuals are also explored.

show abstract

Section: Oxidative Stress In Preterm Newbornsmentioning

confidence: 99%

Section: Oxidative Stress In Preterm Newbornsmentioning

confidence: 99%

Preterm birth and oxidative stress: Effects of acute physical exercise and hypoxia physiological responses

et al. 2018

View full text Add to dashboard Cite

show abstract

“…This can because of lower level of different antioxidant biomarkers. It is explored that at birth, superoxide dismutase (SOD) activity in both blood [18,25] and erythrocytes [19,26], catalase (CAT) activity in blood [9] as well as cytosolic glutathione peroxidase (GPx) in erythrocytes [19] are lower in preterm than in fullterm newborns. Preterm newborns also exhibit lower levels of non-enzymatic antioxidants such as erythrocyte vitamins [27].…”

Section: Discussionmentioning

confidence: 99%

Serum Pro-Oxidant/Antioxidant Balance in Term Versus Preterm Neonates

Boskabadi

Ghayour‐Mobarhan

Saeidinia

2021

Preprint

View full text Add to dashboard Cite

Introduction: The oxidant/antioxidant status balance is a process that begins before birth and premature infants are particularly susceptible to oxidative stress. According to the mechanisms of oxidative stress and lack of study in this field, in this prospective study we aimed to compare the levels of serum pro-oxidant/antioxidant balance (PAB) in preterm versus term babies. Methods: This was a prospective cross sectional study that was performed in Ghaem hospital, a university tertiary hospital, Mashhad, Iran. The study population was included of all term and preterm neonates who were admitted to the hospital within birth time. Results: In our study, 324 neonates were included. One hundred ninety eight neonates were preterm (61.1%) and others were term (38.9%). The mean birth weight of participants was 3267.19± 446.35gr in term and 1658.78± 644.97 gr in preterm neonates. There was significant difference between PAB level in term and preterm neonates. Serum PAB level was significantly lower in preterm neonates rather than term neonates (21.86± 21.01 versus 50.33± 31.69; P=0.001). There was also significant negative correlation between PAB levels and gestational age. Conclusion: According to previous investigations, we showed for the first time in our study that PAB is lower in preterm newborns rather than term ones. This is in line with the hypothesis that oxidative stress is higher in preterm neonates.

show abstract

“…In a study comparing DNA strand breaks as one of many consequences of DNA oxidation in white blood cells, malondialdehyde (an oxidative stress marker), catalase, superoxide dismutase activity, and total antioxidant capacity (markers of antioxidant defense) in the cord blood plasma of a group of 25 preterms and 25 full-term births, Norishadkam highlighted the greater susceptibility to damage to the DNA of preterms compared to babies born at term [34]. Cai et al, assessed the effect of feeding practices on gut microbiome development and oxidative stress in preterm infants [5].…”

Section: Discussionmentioning

confidence: 99%

“…These are non-enzymatic products from the oxidation of amino acid-free radicals and other PUFAs, and are chemically stable. These compounds have been detected electively in lipid-rich tissues, such as brain tissue, which, being rich in polyunsaturated lipids, is highly sensitive to oxidative stress [ 16 , 17 , 18 , 19 , 20 , 21 , 25 , 29 , 30 , 33 , 34 , 35 , 40 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 61 , 65 , 66 , 67 ].…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress in Preterm Infants: Overview of Current Evidence and Future Prospects

et al. 2020

View full text Add to dashboard Cite

Preterm birth (PTB), defined as parturition prior to 37 weeks of gestation, is the leading cause of morbidity and mortality in the neonatal population. The incidence and severity of complications of prematurity increase with decreasing gestational age and birthweight. The aim of this review study is to select the most current evidence on the role of oxidative stress in the onset of preterm complication prevention strategies and treatment options with pre-clinical and clinical trials. We also provide a literature review of primary and secondary studies on the role of oxidative stress in preterm infants and its eventual treatment in prematurity diseases. We conducted a systematic literature search of the Medline (Pubmed), Scholar, and ClinicalTrials.gov databases, retroactively, over a 7-year period. From an initial 777 articles identified, 25 articles were identified that met the inclusion and exclusion criteria. Of these, there were 11 literature reviews: one prospective cohort study, one experimental study, three case-control studies, three pre-clinical trials, and six clinical trials. Several biomarkers were identified as particularly promising, such as the products of the peroxidation of polyunsaturated fatty acids, those of the oxidation of phenylalanine, and the hydroxyl radicals that can attack the DNA chain. Among the most promising drugs, there are those for the prevention of neurological damage, such as melatonin, retinoid lactoferrin, and vitamin E. The microbiome also has an important role in oxidative stress. In conclusion, the most recent studies show that a strong relationship between oxidative stress and prematurity exists and that, unfortunately, there is still little therapeutic evidence reported in the literature.

show abstract

Oxidative stress and DNA damage in the cord blood of preterm infants

Cited by 20 publications

References 31 publications

Preterm birth and oxidative stress: Effects of acute physical exercise and hypoxia physiological responses

Preterm birth and oxidative stress: Effects of acute physical exercise and hypoxia physiological responses

Serum Pro-Oxidant/Antioxidant Balance in Term Versus Preterm Neonates

Oxidative Stress in Preterm Infants: Overview of Current Evidence and Future Prospects

Contact Info

Product

Resources

About