In Vivo Validation of a Less Invasive Gastrostimulator

Lonys, Laurent; Vanhoestenberghe, Anne; Huberty, Vincent; Hiernaux, Martin; Cauche, Nicolas; Julemont, Nicolas; Debelle, Adrien; Huberland, François; Acuña, Vicente; Godfraind, Carmen; Devière, Jacques; Delchambre, Alain; Mathys, Pierre; Deleuze, Stéfan; Nonclercq, Antoine

doi:10.1111/aor.13056

Cited by 11 publications

(11 citation statements)

References 27 publications

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“…The anchor is intended to be placed in a less‐invasive way through single incision percutaneous access with a single step release, 33 with (1) the summarized procedure and (2) the tool illustrated in Figure 1B. The IGS is encapsulated in medical‐grade silicone rubber 34 that was previously validated in vivo by our team 35 . The IGS delivers biphasic square current pulses from 0.5 to 15.0 mA, with a width of 0.2 to 32.0 ms, at a frequency of 20 Hz to 1 kHz.…”

Section: Methodsmentioning

confidence: 99%

“…The IGS is encapsulated in medicalgrade silicone rubber 34 that was previously validated in vivo by our team. 35 The IGS delivers biphasic square current pulses from 0.5 to 15.0 mA, with a width of 0.2 to 32.0 ms, at a frequency of 20 Hz to 1 kHz. Under the use case described in the experimental protocol section, the battery is expected to last a few days to a few weeks without being charged, depending on the delivered stimulation energy.…”

Section: Implantable Gastric Stimulation Devicementioning

confidence: 99%

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Impact of adaptive gastric electrical stimulation on weight, food intake, and food intake rate in dogs

et al. 2021

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Background: Gastric electrical stimulation (GES) has been studied for decades as a promising treatment for obesity. Stimulation pulses with fixed amplitude and pulse width are usually applied, but these have limitations with regard to overcoming habituation to GES and inter-subject variation. This study aims to analyze the efficacy of an adaptive GES protocol for reducing food intake and maintaining lean weight in dogs.Methods: Six beagle dogs were implanted with a remotely programmable gastric stimulator. An adaptive protocol was designed to increase the stimulation energy proportionally to the excess of food consumption, with respect to the dogs' maintenance energy requirements. After surgery and habituation to experimental conditions, the dogs went through both a control and a stimulation period of 4 weeks each, in a randomized order. The stimulation parameters were adapted daily.Body weight, food intake, food intake rate, and postprandial cutaneous electrogastrograms (EGG) were recorded to assess the effect of adaptive GES. Results: Adaptive GES decreased food intake and food intake rate (p < 0.05) resulting in weight maintenance. In the absence of GES, the dogs gained weight (p < 0.05). Postprandial EGG dominant frequency was accelerated by GES (p < 0.05). The strategy of adapting the stimulation energy was effective in causing significant mid-term changes. Conclusion:Adaptive GES is effective for reducing food intake and maintaining lean weight. The proposed adaptive strategy may offer benefits to counter habituation and adapt to inter-subject variation in clinical use of GES for obesity.

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Section: Methodsmentioning

confidence: 99%

Section: Implantable Gastric Stimulation Devicementioning

confidence: 99%

Impact of adaptive gastric electrical stimulation on weight, food intake, and food intake rate in dogs

et al. 2021

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“…Leslie's soup is a mixture of 0.5 wt% detergent (Teepol-L, Teepol Products, Kent, United Kingdom), and 25 wt% trisodium phosphate (anhydrous, 13438, Alfa Aesar, Heysham, United Kingdom), in de-ionized water. Cleanliness before encapsulation is essential for the survival of long-term implants (Vanhoestenberghe and Donaldson, 2013;Lonys et al, 2017;Kiele et al, 2020). Following rinsing, the conductivity of the rinse solution was monitored to confirm adequate cleanliness.…”

Section: Implant Packaging and Encapsulationmentioning

confidence: 99%

A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications

et al. 2021

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This article presents a versatile neurostimulation platform featuring a fully implantable multi-channel neural stimulator for chronic experimental studies with freely moving large animal models involving peripheral nerves. The implant is hermetically sealed in a ceramic enclosure and encapsulated in medical grade silicone rubber, and then underwent active tests at accelerated aging conditions at 100°C for 15 consecutive days. The stimulator microelectronics are implemented in a 0.6-μm CMOS technology, with a crosstalk reduction scheme to minimize cross-channel interference, and high-speed power and data telemetry for battery-less operation. A wearable transmitter equipped with a Bluetooth Low Energy radio link, and a custom graphical user interface provide real-time, remotely controlled stimulation. Three parallel stimulators provide independent stimulation on three channels, where each stimulator supports six stimulating sites and two return sites through multiplexing, hence the implant can facilitate stimulation at up to 36 different electrode pairs. The design of the electronics, method of hermetic packaging and electrical performance as well as in vitro testing with electrodes in saline are presented.

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“…Lonys et al of the Université Libre de Bruxelles, Brussels, Belgium reported on gastrointestinal stimulator implants that have been shown promising in helping obese patients lose weight. They developed a less invasive procedure to stimulate the stomach by creating a single incision percutaneous procedure.…”

Section: Functional Electrical Stimulation and Musculoskeletal Supportmentioning

confidence: 99%

Artificial Organs 2017: A Year in Review

Malchesky¹

2018

Artificial Organs

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In this Editor's Review, articles published in 2017 are organized by category and summarized. We provide a brief reflection of the research and progress in artificial organs intended to advance and better human life while providing insight for continued application of these technologies and methods. Artificial Organs continues in the original mission of its founders "to foster communications in the field of artificial organs on an international level." Artificial Organs continues to publish developments and clinical applications of artificial organ technologies in this broad and expanding field of organ Replacement, Recovery, and Regeneration from all over the world. Peer-reviewed Special Issues this year included contributions from the 12th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion edited by Dr. Akif Undar, Artificial Oxygen Carriers edited by Drs. Akira Kawaguchi and Jan Simoni, the 24th Congress of the International Society for Mechanical Circulatory Support edited by Dr. Toru Masuzawa, Challenges in the Field of Biomedical Devices: A Multidisciplinary Perspective edited by Dr. Vincenzo Piemonte and colleagues and Functional Electrical Stimulation edited by Dr. Winfried Mayr and colleagues. We take this time also to express our gratitude to our authors for offering their work to this journal. We offer our very special thanks to our reviewers who give so generously of time and expertise to review, critique, and especially provide meaningful suggestions to the author's work whether eventually accepted or rejected. Without these excellent and dedicated reviewers the quality expected from such a journal could not be possible. We also express our special thanks to our Publisher, John Wiley & Sons for their expert attention and support in the production and marketing of Artificial Organs. We look forward to reporting further advances in the coming years.

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In Vivo Validation of a Less Invasive Gastrostimulator

Cited by 11 publications

References 27 publications

Impact of adaptive gastric electrical stimulation on weight, food intake, and food intake rate in dogs

Impact of adaptive gastric electrical stimulation on weight, food intake, and food intake rate in dogs

A Versatile Hermetically Sealed Microelectronic Implant for Peripheral Nerve Stimulation Applications

Artificial Organs 2017: A Year in Review

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