Role of DJ-1 in Fertilization

Chen, An; Pu, Xiaoping

doi:10.1007/978-981-10-6583-5_5

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…Indeed, the majority of human cancers overexpress DJ-1 mRNA [28] and it is highly expressed in testicles, all of which are high-energy demand tissues characterized by a high glycolytic flux. Indeed, decreased expression of DJ-1 in sperm and epididymides correlates with male infertility [29,30]. DJ-1 protein levels also increase in human islets of Langerhans beta cells upon exposure to high glucose concentrations, indicating a protective role for DJ-1 in this cell type [31,32].…”

Section: Introductionmentioning

confidence: 99%

DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives

Repici

Giorgini

2019

JCM

114

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Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson’s disease (PD) and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions have been ascribed to DJ-1 (most notably protection from oxidative stress), its contribution to PD pathogenesis is not yet clear. Here we provide an overview of the clinical research to date on DJ-1 and the current state of knowledge regarding DJ-1 characterization in the human brain. The relevance of DJ-1 as a PD biomarker is also discussed, as are studies exploring DJ-1 as a possible therapeutic target for PD and neurodegeneration.

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Section: Introductionmentioning

confidence: 99%

DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives

Repici

Giorgini

2019

JCM

114

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“…It can enhance the hypothalamic-pituitary-adrenal function and promote the release of relevant transmitters and hormones in vivo to play the role of tonifying kidney essence, and also has the role of protecting cerebral ischemia. Other studies have shown that [11], cistanche total glycosides can protect cerebral ischemia and cerebral ischemia-reperfusion injury. Animal experiments showed that it can protect cerebral ischemia and cerebral ischemia reperfusion injury by decreasing stroke index, percentage of cerebral infarction area, malondialdehyde content and nitric oxide synthase activity in brain tissue, and increasing superoxide dismutase activity in brain tissue.…”

Section: Modern Pharmacological Researchmentioning

confidence: 91%

Summary of Dihuang Yinzi Treatment of Hepatorenal Yin Deficiency Type Apoplexy

2022

IJWM

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Rehmannia yinzi is Liu Hejian's name, indications for the stroke, is now more by later doctors for the treatment of cerebrovascular disease stroke, liver and kidney Yin deficiency type.This article discusses the history of apoplexy, the application of rehmannia glutinis in ancient and modern times and the experimental and clinical research. Historical Evolution of Stroke TheoryApoplexy is a kind of complicated and complicated disease of traditional Chinese medicine, which is common in middle-aged and elderly people. It has the clinical characteristics of high incidence, high disability rate and high mortality. Based on the characteristics of modern People's Daily life and the food characteristics of fat and sweet taste, the age of stroke has been young. About stroke, ancient Chinese books have long been recorded, "Stroke Calendar Section" [1] There is a cloud: "evil lies in collateral, skin is not benevolent, evil lies in the classics, namely heavy and numerous; When evil enters the inside, he does not know the man; when evil enters the viscera, the tongue stumbles and the mouth salivates." And before jinyuan, physicians thought that stroke as the "wind", the basis of the theory is derived from huangdi neijing, its cloud "of blood and qi, and walk in the" "great anger, he breathed his last, and blood Wan in", and put forward the hemiplegia in this "Fried jue" BoJue disease ", "the view jinyuan period doctor thought that stroke of modern internal injuries, closely related to exogenous pathogenic wind. Synopsis of the Golden Chamber • Disease pulse syndrome and Treatment of Apoplexy Calendar Section Fifth [2] Further refined put forward the evil "in the zang" "in the fu" "in the meridian" "in the luo", and fengyin soup, Hou's black powder and other prescriptions for the treatment of stroke. To the Sui and Tang Dynasties [3] Chao

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“…Another protein implicated in PD pathogenesis is DJ-1, a small, dimeric protein that is most highly expressed in cells with high energy demands, such as neurons. Cells with high energy demand typically have high levels of reactive oxygen species, and one function of DJ-1 is to protect cells from oxidative stress (Wagenfeld et al, 1998;Kinumi et al, 2004;Taira et al, 2004;Kim et al, 2005;Meulener et al, 2005;Wilson, 2011;Jain et al, 2012;Ottolini et al, 2013;Batelli et al, 2015;Chunna and Pu, 2017;Eberhard and Lammert, 2017;Kawate et al, 2017;Kiss et al, 2017;Smith and Wilson, 2017;Catazaro et al, 2018). DJ-1 has also been implicated to act as a chaperone, modulating the toxicity and misfolding of both α-synuclein and mutant huntingtin (Batelli et al, 2008;Wang et al, 2011;Sajjad et al, 2014;Zondler et al, 2014).…”

Section: Dj-1mentioning

confidence: 99%

Dictyostelium discoideum as a Model for Investigating Neurodegenerative Diseases

Haver

Scaglione

2021

Front. Cell. Neurosci.

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The social amoeba Dictyostelium discoideum is a model organism that is used to investigate many cellular processes including chemotaxis, cell motility, cell differentiation, and human disease pathogenesis. While many single-cellular model systems lack homologs of human disease genes, Dictyostelium’s genome encodes for many genes that are implicated in human diseases including neurodegenerative diseases. Due to its short doubling time along with the powerful genetic tools that enable rapid genetic screening, and the ease of creating knockout cell lines, Dictyostelium is an attractive model organism for both interrogating the normal function of genes implicated in neurodegeneration and for determining pathogenic mechanisms that cause disease. Here we review the literature involving the use of Dictyostelium to interrogate genes implicated in neurodegeneration and highlight key questions that can be addressed using Dictyostelium as a model organism.

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Role of DJ-1 in Fertilization

Abstract: Neither a sperm nor an egg can develop into an individual alone. Only when the sperm and egg bind and fuse, which is known as fertilization, can they acquire the ability of developing into new individuals. DJ-1 was reported to be involved in the process of fertilization.

Cited by 5 publications

References 8 publications

DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives

DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives

Summary of Dihuang Yinzi Treatment of Hepatorenal Yin Deficiency Type Apoplexy

Dictyostelium discoideum as a Model for Investigating Neurodegenerative Diseases

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