Two threshold levels of vitamin D and the prevalence of comorbidities in outpatients of a tertiary hospital

Furuie, I. N.; Maurantonio, Mauro; Petruzziello, S.; Riechi, Salomão Cury; Petterle, Ricardo Rasmussen; Boguszewski, César Luiz; Borba, Victória Zeghbi Cochenski

doi:10.1007/s00198-017-4299-2

Cited by 1 publication

(1 citation statement)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the absence of information, in recent years there have been plenty of studies on the beneficial role of VD in cancer [17], cardiovascular disease (CVD) [18], diabetes mellitus [19] and obesity [20], amongst other diseases. Moreover, low VD levels have been related to a higher prevalence of comorbidities in the clinical setting [21]. Together, these studies have shown that VD has many biological functions beyond regulating the skeletal homeostasis [22].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency and COVID-19: A Biological Database Study on Pathways and Gene-Disease Associations

Alcalá-Santiago

Rodriguez‐Barranco

Rava

et al. 2022

IJMS

View full text Add to dashboard Cite

Vitamin D (VD) is a fat-soluble vitamin, and pivotal for maintaining health. Several genetic markers have been related to a deficient VD status; these markers could confer an increased risk to develop osteoporosis and other chronic diseases. A VD deficiency could also be a determinant of a severe COVID-19 disease. This study aimed to interrogate genetic/biological databases on the biological implications of a VD deficiency and its association with diseases, to further explore its link with COVID-19. The genetic variants of both a VD deficiency and COVID-19 were identified in the genome-wide association studies (GWAS) catalog and other sources. We conducted enrichment analyses (considering corrected p-values < 0.05 as statistically significant) of the pathways, and gene-disease associations using tools, such as FUMA, REVIGO, DAVID and DisGeNET, and databases, such as the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO). There were 26 and 46 genes associated with a VD deficiency and COVID-19, respectively. However, there were no genes shared between the two. Genes related to a VD deficiency were involved in the metabolism of carbohydrates, retinol, drugs and xenobiotics, and were associated with the metabolic syndrome and related factors (obesity, hypertension and diabetes mellitus), as well as with neoplasms. There were few enriched pathways and disease connections for the COVID-19-related genes, among which some of the aforementioned comorbidities were also present. In conclusion, genetic factors that influence the VD levels in the body are most prominently associated with nutritional and metabolic diseases. A VD deficiency in high-risk populations could be therefore relevant in a severe COVID-19, underlining the need to examine whether a VD supplementation could reduce the severity of this disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency and COVID-19: A Biological Database Study on Pathways and Gene-Disease Associations

Alcalá-Santiago

Rodriguez‐Barranco

Rava

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

Two threshold levels of vitamin D and the prevalence of comorbidities in outpatients of a tertiary hospital

Abstract: Patients with serum 25OHD ≥ 20 and < 30 ng/mL had higher prevalence of comorbidities compared to ≥ 30 ng/mL.

Cited by 1 publication

References 39 publications

Vitamin D Deficiency and COVID-19: A Biological Database Study on Pathways and Gene-Disease Associations

Vitamin D Deficiency and COVID-19: A Biological Database Study on Pathways and Gene-Disease Associations

Contact Info

Product

Resources

About