Phenotypic characteristics associated with slow gait speed in idiopathic pulmonary fibrosis

Abstract

4MGS is a simple, reliable, valid and responsive tool that may detect a patient phenotype with worse exercise performance, dyspnoea, health status and prognosis index in stable IPF.

Relative Protein Intake and Physical Function in Older Adults: A Systematic Review and Meta-Analysis of Observational Studies

“…On the other hand, walking ability needs a larger integration among the body systems in comparison with sit and stand up or tightening an object. Indeed, walking is a complex activity involving a variety of neural process (e.g., sensory, cortical cognitive, temporal) [ 40 , 41 ], cerebral and peripheral vascular beds [ 42 , 43 ], as well as lung [ 44 ], cardiac and muscular functions [ 45 ], to list a few. Consequently, walking ability represents the functioning of multiple organ systems instead of just one system [ 46 ], and marked disturbances in gait pattern may occur in response to cardiovascular, neurological and neuromuscular pathologies [ 40 , 41 ].…”

Which functional outcome measures can we use as a surrogate for exercise capacity during remote cardiopulmonary rehabilitation assessments? A rapid narrative review

“…Interrater reliability was the most commonly reported measure using intraclass correlation coefficient (ICC). These were all moderate, good or excellent, range 0.68 [5STS (38) (27,(29)(30)34). 2 studies reported limits of agreement between 2 testing sessions for the 4MGS: these were 0.09 to -0.09 (34) and 0.135 to -0.125 (30).…”

“…These were all moderate, good or excellent, range 0.68 [5STS (38) (27,(29)(30)34). 2 studies reported limits of agreement between 2 testing sessions for the 4MGS: these were 0.09 to -0.09 (34) and 0.135 to -0.125 (30). One study examined the limits of agreement for the peak oxygen uptake (VO 2 ) predicated from the DASI questionnaire and Chester step test with the CPET (36).…”

“…Many of the studies were single time point/ not testing response to an intervention. However the sensitivity of the tests was explored in 6 studies, generally following exercisebased rehabilitation (27,29,34,36,(38)(39). 1 study suggested an MCID for the 5STS in patients with COPD: 1.3-1.7 seconds (29) and the MID for this outcome was reported as 7.5 seconds in patients with CKD (38).…”

Contemporary Concise Review 2018: Interstitial lung disease

“…The European IPF registry conducted an analysis that confirmed the demography, the clinical progression and the success of the antifibrotic treatment in improving survival in IPF. The progression of IPF is challenging and hard to foresee, but the slow gait speed in IPF could be a simple, reliable tool that may detect phenotypes associated with a worse clinical outcome. The efforts to better define the risk factors of IPF progression had led to the environmental analysis and a real association with air pollution and long‐term exposure to PM 10 and PM 2.5 linked to an increase of the mortality …”