Effects of multidomain lifestyle intervention, omega-3 supplementation or their combination on physical activity levels in older adults: secondary analysis of the Multidomain Alzheimer Preventive Trial (MAPT) randomised controlled trial

Barreto, Philipe de Souto; Rolland, Yves; Cesari, Matteo; Dupuy, Charlotte; Andrieu, Sandrine; Vellas, Bruno

doi:10.1093/ageing/afx164

Cited by 19 publications

(12 citation statements)

References 30 publications

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“…Physical activity is the cornerstone of the prevention of mobility disability in older adults, but the usual recommended volume of training is difficult to achieve in older adults and in the long term. Even though a previous study using MAPT data has shown the positive effects of the MAPT multidomain intervention on overall PA [26], this PA increasing was not enough to improve physical function; this suggests that the multidomain intervention, even among participants with a high adherence, was not strong enough to result in a significant benefit on physical performance. Moreover, the present study failed to demonstrate that ω3-PUFA would potentiate the effects of physical activity for determining physical function in older adults as suggested in exercise training studies in healthy younger adults [11,12] and middle-aged/younger older adults [27].…”

Section: Discussionmentioning

confidence: 87%

Effect of Long-Term Omega 3 Polyunsaturated Fatty Acid Supplementation with or without Multidomain Lifestyle Intervention on Muscle Strength in Older Adults: Secondary Analysis of the Multidomain Alzheimer Preventive Trial (MAPT)

Rolland

Barreto

Maltais³

et al. 2019

Nutrients

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Background: The benefits of long-term omega 3 polyunsaturated fatty acid (ω3-PUFA) supplementation on muscle strength in older adults remains to be investigated. Objectives: We assessed the effect of ω3-PUFA supplementation and a multidomain (physical activity, cognitive training, and nutritional advice), alone or in combination, compared with placebo, on muscle strength. We also hypothesized that ω3-PUFA supplementation resulted in additional benefit in participants with a low docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) erythrocyte level at baseline and high adherence to the multidomain intervention sessions. Design: We performed secondary analyses of the Multidomain Alzheimer Preventive Trial (MAPT), a 3-year, multicenter, randomized, placebo-controlled trial with four parallel groups. Participants were non-demented, aged 70 years or older. They were recruited in 13 memory clinics in France and Monaco between 30 May 2008 and 24 February 2011. Participants were randomly assigned to either ω3-PUFA alone (two capsules a day providing a total daily dose of 800 mg DHA and 225 mg EPA), ω3-PUFA plus the multidomain intervention (43 group sessions integrating advice for physical activity (PA), and nutrition, cognitive training, and three preventive consultations), the multidomain intervention plus placebo, or placebo alone. Our primary outcome was the change from baseline to 36 months of the muscle strength assessed with the repeated chair stand test and handgrip strength. Results: A total of 1680 participants (75.34 years ± 4.42) were randomized. In the modified intention-to-treat population (n = 1679), no significant differences at 3-year follow-up were observed in the repeated chair stand test score between any of the three intervention groups and the placebo group. The between-group differences compared with placebo were −0.05388 (−0.6800 to 0.5723; Standard Error, SE = 0.3192; p = 0.8660) for the ω3-PUFA group, −0.3936 (−1.0217 to 0.2345; SE = 0.3180; p = 0.2192) for the multidomain intervention plus placebo group, and −0.6017 (−1.2255 to 0.02222; SE = 0.2092; p = 0.3202) for the combined intervention group. No significant effect was also found for the handgrip strength. Sensitivity analyses performed among participants with low (DHA+EPA) erythrocyte level at baseline (first quartile vs. others) or highly adherent participants (≥75% of the multidomain intervention sessions) revealed similar results. Conclusion: Low dose ω3-PUFA supplementation, either alone or in combination with a multidomain lifestyle intervention comprising physical activity counselling, had no significant effects on muscle strength over 3 years in elderly people.

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Section: Discussionmentioning

confidence: 87%

Effect of Long-Term Omega 3 Polyunsaturated Fatty Acid Supplementation with or without Multidomain Lifestyle Intervention on Muscle Strength in Older Adults: Secondary Analysis of the Multidomain Alzheimer Preventive Trial (MAPT)

Rolland

Barreto

Maltais³

et al. 2019

Nutrients

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“…The inclusion criteria were as follows: The period of the publishing of the article was not limited; Only reviewed full-text studies in scientific journals in English were included; Only randomized controlled trials, cohort studies, or experimental/cross-sectional studies were involved and they had to include at least two interventions in different domains, of which one had to be diet/nutritional intervention; The primary outcome was aimed at the improvement in cognitive function; The subjects were healthy older individuals aged 50+ years. The exclusion criteria were as follows: The study was in a language other than English; The study did not involve healthy older individuals; The study protocols such as References [ 13 , 14 , 15 ], multidomain lifestyle interventions focusing on just one strategy [ 22 ], single lifestyle intervention studies [ 19 , 23 , 24 ], multidomain lifestyle studies that did not include diet intervention [ 25 ], multidomain lifestyle studies that did not focus on the improvement in cognitive function [ 26 ], and review studies (e.g., References [ 10 , 11 , 27 , 28 ]) were also excluded. …”

Section: Methodsmentioning

confidence: 99%

“…The study protocols such as References [ 13 , 14 , 15 ], multidomain lifestyle interventions focusing on just one strategy [ 22 ], single lifestyle intervention studies [ 19 , 23 , 24 ], multidomain lifestyle studies that did not include diet intervention [ 25 ], multidomain lifestyle studies that did not focus on the improvement in cognitive function [ 26 ], and review studies (e.g., References [ 10 , 11 , 27 , 28 ]) were also excluded.…”

Section: Methodsmentioning

confidence: 99%

Multidomain Lifestyle Intervention Strategies for the Delay of Cognitive Impairment in Healthy Aging

2018

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Present demographic changes demonstrate that the number of elderly people is growing at a frenetic pace. This shift in population consequently results in many social and economic problems, which burden the social and economic systems of countries. The aging process is associated with age-related diseases, the most common of which are dementia and Alzheimer’s disease, whose main symptom is a decline in cognitive function, especially memory loss. Unfortunately, it cannot be cured. Therefore, alternative approaches, which are cost-effective, safe, and easy to implement, are being sought in order to delay and prevent cognitive impairment. The purpose of this review was to explore the effect of multidomain lifestyle intervention strategies on the delay and/or prevention of cognitive impairment in healthy older individuals. The methods are based on a literature review of available sources found on the research topic in three acknowledged databases: Web of Science, Scopus, and PubMed. The results of the identified original studies reveal that multidomain lifestyle interventions generate significant effects. In addition, these interventions seem feasible, cost-effective, and engaging. Thus, there is a call for the implementation of effective lifestyle prevention programs, which would involve goal-setting and would focus on the prevention of crucial risk factors threatening the target group of elderly people, who are at risk of cognitive decline and dementia.

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“…In two of the studies the primary outcome was reducing frailty (Barreto, 2018;de Vries, 2013), in one study the primary outcome was fall prevention and one of the studies had multiple health outcomes . The participants represented in our synthesis are significantly older than previous syntheses, with mean ages range from 71.6 to 85.3.…”

Section: Findings Study Characteristicsmentioning

confidence: 99%

“…For all groups of participants represented, at least one between-group statistic was reported. Six of the studies utilized objective measures of PA outcomes, such as accelerometer and pedometer (Barreto et al, 2018.…”

Section: Findings Study Characteristicsmentioning

confidence: 99%

Systematic Review and Meta-Analysis of Primary Care-Based Physical Activity Interventions Among Older Adults

Otmanowski

Chase

2022

Journal of Aging and Physical Activity

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The purpose of this research is to identify the effectiveness of primary care-based interventions designed to increase older adults’ physical activity (PA). Primary care was defined as a patient’s main source of health care. Standardized mean difference effect size (ES) was calculated related to changes in PA levels in adults’ ≥65. Moderator analysis was performed to explore the relationship between participant characteristics, interventions, interventionists, and ES. Overall mean ES 0.27 (95% confidence interval [0.15, 0.39], p < .01) was calculated for 25 two-group comparisons involving 4,685 total participants with a mean age of 75.08. There was little evidence to support counseling over exercise referrals. The use of theory or a pedometer did not modify the ES. PA interventions delivered in primary care are effective and can be delivered by other health-care providers working with the primary provider. Many different behavior change strategies may be used to promote PA.

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Effects of multidomain lifestyle intervention, omega-3 supplementation or their combination on physical activity levels in older adults: secondary analysis of the Multidomain Alzheimer Preventive Trial (MAPT) randomised controlled trial

Cited by 19 publications

References 30 publications

Effect of Long-Term Omega 3 Polyunsaturated Fatty Acid Supplementation with or without Multidomain Lifestyle Intervention on Muscle Strength in Older Adults: Secondary Analysis of the Multidomain Alzheimer Preventive Trial (MAPT)

Effect of Long-Term Omega 3 Polyunsaturated Fatty Acid Supplementation with or without Multidomain Lifestyle Intervention on Muscle Strength in Older Adults: Secondary Analysis of the Multidomain Alzheimer Preventive Trial (MAPT)

Multidomain Lifestyle Intervention Strategies for the Delay of Cognitive Impairment in Healthy Aging

Systematic Review and Meta-Analysis of Primary Care-Based Physical Activity Interventions Among Older Adults

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