Cortical thinning correlates of changes in visuospatial and visuoperceptual performance in Parkinson's disease: A 4-year follow-up

García-Díaz, Anna Isabel; Segura, Bàrbara; Baggio, Hugo C.; Uribe, Carme; Campabadal, Anna; Abós, Alexandra; Martí, María Josep; Valldeoriola, Francesc; Compta, Yaroslau; Bargalló, Núria; Junqué, Carme

doi:10.1016/j.parkreldis.2017.11.003

Cited by 55 publications

(43 citation statements)

References 35 publications

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“…29 According to our findings in PD-CNtoMCI, several cross-sectional MRI studies established a link between atrophy of posterior regions (mainly involving the parietal lobe) and cognitive impairment in PD patients, 30,31 and previous longitudinal studies assessing the conversion from normal cognition to MCI in PD patients showed greater progressive cortical thinning in parieto-temporooccipital regions. 5,32 The presence of early and progressive cortical abnormalities involving posterior areas has been recently demonstrated in early-diagnosed PD patients in association with reduced striatal dopamine transporter uptake. 33 Thus, these abnormalities, together with their association with lower cognitive performance of patients over time, were interpreted as an early indicator of dopaminergic depletion and a marker of neurodegenerative processes.…”

Section: Discussionmentioning

confidence: 99%

Tracking Cortical Changes Throughout Cognitive Decline in Parkinson's Disease

et al. 2020

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A BS TRACT: Background: The objectives of this study were to investigate progressive cortical thinning and volume loss in Parkinson's disease (PD) patients with different longitudinal patterns of cognitive decline: with stable normal cognition, with stable mild cognitive impairment, with conversion to mild cognitive impairment, and with conversion to dementia. Methods: We recruited 112 patients (37 Parkinson's disease with stable normal cognition, 20 Parkinson's disease with stable mild cognitive impairment, 36 Parkinson's disease with conversion to mild cognitive impairment, 19 Parkinson's disease with conversion to dementia) and 38 healthy controls. All patients underwent at least 2 visits within 4 years including clinical/cognitive assessments and structural MRI (total visits, 393). Baseline cortical thickness and gray matter volumetry were compared between groups. In PD, gray matter changes over time were investigated and compared between groups. Results: At baseline, compared with Parkinson's disease with stable normal cognition cases, Parkinson's disease with conversion to mild cognitive impairment patients showed cortical atrophy of the parietal and occipital lobes, similar to Parkinson's disease with stable mild cognitive impairment and Parkinson's disease with conversion to dementia patients. The latter groups (ie, patients with cognitive impairment from the study entry) showed additional involvement of the frontotemporal cortices. No baseline volumetric differences among groups were detected. The longitudinal analysis (group-by-time interaction) showed that, versus the other patient groups, Parkinson's disease with stable mild cognitive impairment and Parkinson's disease with conversion to dementia cases accumulated the least cortical damage, with Parkinson's disease with conversion to dementia showing unique progression of right thalamic and hippocampal volume loss; Parkinson's disease with conversion to mild cognitive impairment patients showing specific cortical thinning accumulation in the medial and superior frontal gyri, inferior temporal, precuneus, posterior cingulum, and supramarginal gyri bilaterally; and Parkinson's disease with stable normal cognition patients showing cortical thinning progression, mainly in the occipital and parietal regions bilaterally. Conclusions: Cortical thinning progression is more prominent in the initial stages of PD cognitive decline. The involvement of frontotemporoparietal regions, the hippocampus, and the thalamus is associated with conversion to a more severe stage of cognitive impairment. In PD, gray matter alterations of critical brain regions may be an MRI signature for the identification of patients at risk of developing dementia.

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Section: Discussionmentioning

confidence: 99%

Tracking Cortical Changes Throughout Cognitive Decline in Parkinson's Disease

et al. 2020

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“…It is worth noting that when assessing specifically VS/VP functions in PD, structural substrates encompass cortical thinning in lateral temporoparietal regions ( Garcia-Diaz et al, 2018a , Garcia-Diaz et al, 2014 ). Moreover, as PD progresses, VS/VP impairment is accompanied by bilateral posterior degeneration ( Garcia-Diaz et al, 2018b ). Although further longitudinal data with larger samples are needed to confirm our results, the decline in VS/VP performance might help to identify those patients presenting progressive neurodegeneration in posterior cortices.…”

Section: Discussionmentioning

confidence: 99%

Cortical gray matter progression in idiopathic REM sleep behavior disorder and its relation to cognitive decline

Campabadal

Inguanzo

Segura

et al. 2020

NeuroImage: Clinical

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Highlights Cortical degeneration over time in IRBD patients is larger than in normal aging. IRBD patients have progressive parieto-occipital and orbitofrontal thinning. Visuospatial decline in IRBD is associated with degeneration in parietal regions. Increasing motor signs in IRBD are related to frontal and parietal degeneration. Cortical thinning in posterior regions is associated with late-onset IRBD.

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“…It may not be fully interpreted by the spread of β-amyloid pathology alone [18•], but future studies that combine amyloid/tau PET and sMRI are warranted to shed further light on this assumption. Future studies should also explore how cholinergic neuron losses in the nucleus basalis of Meynert and other cholinergic structures of the basal forebrain impact the SPARE-AD pattern of atrophy in PD and the progression of memory and visuospatial deficits in PD [73]. Further studies exploring the effect of atrophy on distinct hippocampal subfields are also awaited.…”

Section: Discussionmentioning

confidence: 99%

Gray Matter Changes in Parkinson’s and Alzheimer’s Disease and Relation to Cognition

Krajcovicova

Klobušiaková

Rektorová

2019

Curr Neurol Neurosci Rep

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Purpose of ReviewWe summarize structural (s)MRI findings of gray matter (GM) atrophy related to cognitive impairment in Alzheimer’s disease (AD) and Parkinson’s disease (PD) in light of new analytical approaches and recent longitudinal studies results.Recent FindingsThe hippocampus-to-cortex ratio seems to be the best sMRI biomarker to discriminate between various AD subtypes, following the spatial distribution of tau pathology, and predict rate of cognitive decline. PD is clinically far more variable than AD, with heterogeneous underlying brain pathology. Novel multivariate approaches have been used to describe patterns of early subcortical and cortical changes that relate to more malignant courses of PD.SummaryNew emerging analytical approaches that combine structural MRI data with clinical and other biomarker outcomes hold promise for detecting specific GM changes in the early stages of PD and preclinical AD that may predict mild cognitive impairment and dementia conversion.Electronic supplementary materialThe online version of this article (10.1007/s11910-019-1006-z) contains supplementary material, which is available to authorized users.

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Cortical thinning correlates of changes in visuospatial and visuoperceptual performance in Parkinson's disease: A 4-year follow-up

Abstract: In this study, we establish the neuroanatomical substrate of progressive changes in VS/VP performance in PD patients with and without MCI. In agreement with cross-sectional data, VS/VP changes over time are related to cortical thinning in posterior regions.

Cited by 55 publications

References 35 publications

Tracking Cortical Changes Throughout Cognitive Decline in Parkinson's Disease

Tracking Cortical Changes Throughout Cognitive Decline in Parkinson's Disease

Cortical gray matter progression in idiopathic REM sleep behavior disorder and its relation to cognitive decline

Gray Matter Changes in Parkinson’s and Alzheimer’s Disease and Relation to Cognition

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