Effect of green tea on plasma leptin and ghrelin levels: A systematic review and meta-analysis of randomized controlled clinical trials

Haghighatdoost, Fahimeh; Gh, B. Fatemeh Nobakht M.; Hariri, Mitra

doi:10.1016/j.nut.2017.06.022

Cited by 15 publications

(10 citation statements)

References 48 publications

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“…Both leptin and adiponectin levels were unaffected across the intervention with dGTE or dGTE+. This agrees with a recent meta-analysis [82] demonstrating that leptin concentration is likely unaffected with GT (from all sources) when consumed for less than 12 weeks. In contrast, longer-term use of GT (>12 weeks) likely increases leptin concentrations (effect size: 2.90 [82]).…”

Section: Vo 2peak )supporting

confidence: 92%

The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals

et al. 2021

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This study investigated the effect of decaffeinated green tea extract (dGTE), with or without antioxidant nutrients, on fat oxidation, body composition and cardio-metabolic health measures in overweight individuals engaged in regular exercise. Twenty-seven participants (20 females, 7 males; body mass: 77.5 ± 10.5 kg; body mass index: 27.4 ± 3.0 kg·m2; peak oxygen uptake (O2peak): 30.2 ± 5.8 mL·kg−1·min−1) were randomly assigned, in a double-blinded manner, either: dGTE (400 mg·d−1 (−)-epigallocatechin−3-gallate (EGCG), n = 9); a novel dGTE+ (400 mg·d−1 EGCG, quercetin (50 mg·d−1) and α-lipoic acid (LA, 150 mg·d−1), n = 9); or placebo (PL, n = 9) for 8 weeks, whilst maintaining standardised, aerobic exercise. Fat oxidation (‘FATMAX’ and steady state exercise protocols), body composition, cardio-metabolic and blood measures (serum glucose, insulin, leptin, adiponectin, glycerol, free fatty acids, total cholesterol, high [HDL-c] and low-density lipoprotein cholesterol [LDL-c], triglycerides, liver enzymes and bilirubin) were assessed at baseline, week 4 and 8. Following 8 weeks of dGTE+, maximal fat oxidation (MFO) significantly improved from 154.4 ± 20.6 to 224.6 ± 23.2 mg·min−1 (p = 0.009), along with a 22.5% increase in the exercise intensity at which fat oxidation was deemed negligible (FATMIN; 67.6 ± 3.6%O2peak, p = 0.003). Steady state exercise substrate utilisation also improved for dGTE+ only, with respiratory exchange ratio reducing from 0.94 ± 0.01 at week 4, to 0.89 ± 0.01 at week 8 (p = 0.004). This corresponded with a significant increase in the contribution of fat to energy expenditure for dGTE+ from 21.0 ± 4.1% at week 4, to 34.6 ± 4.7% at week 8 (p = 0.006). LDL-c was also lower (normalised fold change of −0.09 ± 0.06) for dGTE+ by week 8 (p = 0.038). No other significant effects were found in any group. Eight weeks of dGTE+ improved MFO and substrate utilisation during exercise, and lowered LDL-c. However, body composition and cardio-metabolic markers in healthy, overweight individuals who maintained regular physical activity were largely unaffected by dGTE.

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Section: Vo 2peak )supporting

confidence: 92%

The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals

et al. 2021

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“…Green tea ( Camellia sinensis ) is a popular beverage in China and used as a traditional medicine. Scientists believe habitual intake of green tea has favorable health outcomes such as ameliorating obesity‐related hormones (Haghighatdoost, Nobakht, & Hariri, , ), decreasing risk of chronic diseases such as diabetes mellitus (Iso, Date, Wakai, Fukui, & Tamakoshi, ), metabolic syndrome (Thielecke & Boschmann, ), dyslipidemia (Imai & Nakachi, ), hypertension (Yang, Lu, Wu, Wu, & Chang, ), and cardiovascular disease (Sasazuki et al, ). Recent evidence indicated that green tea, as a rich dietary source for flavonoids, might also be able to reduce inflammatory mediators (Basu et al, ; Bogdanski et al, ; Oyama et al, ).…”

Section: Introductionmentioning

confidence: 99%

The effect of green tea on inflammatory mediators: A systematic review and meta‐analysis of randomized clinical trials

Haghighatdoost

Hariri

2019

Phytotherapy Research

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Catechin in green tea might be able to reduce inflammatory mediators; therefore, in this study, we aimed to indicate green tea effects on inflammatory mediators such as tumor necrosis factor‐alpha (TNF‐α), C‐reactive protein (CRP), and interleukin‐6 (IL‐6). The advanced search methods of electronic databases were used to find randomized clinical trials that assessed green tea effect on inflammatory mediators among adult population. Google Scholar, PubMed/Medline, EMBASE, SCOPUS, and ISI Web of Science were searched until January 2019. Delphi checklist was used for assessing the quality of included articles. Mean changes in serum inflammatory biomarkers were calculated by subtracting endpoint values from the baseline in each study arm. Then the effect size for each selected study was estimated as the difference between mean changes in the intervention and control groups. We included 16 articles in our meta‐analysis and 17 articles in systematic review. Our results indicated that green tea could not significantly decrease serum CRP levels and significantly increased IL‐6 and significantly decreased TNF‐α levels. In conclusion, green tea might not be able to change inflammatory mediators especially in diseases with low inflammation, but scientists who want to assess green tea effect on inflammatory mediators should perform their study on patients with high inflammation. Studies exclusive on male or female and considering nutrients intake as a confounding factor are a necessity.

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“…A meta-analysis that instead examined the effect of green tea on leptin levels revealed that this hormone increased only in case of treatments lasting more than 12 weeks. Therefore, the anti-inflammatory effect of green tea, which involves a reduction in the synthesis of leptin, exercised only in case of prolonged treatment [169,120].…”

Section: Metabolic Alterationsmentioning

confidence: 99%

Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome

et al. 2021

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Metabolic syndrome (MetS) is a clinical manifestation characterized by a plethora of comorbidities, including hyperglycemia, abdominal obesity, arterial hypertension, and dyslipidemia. All MetS comorbidities participate to induce a low-grade inflammation state and oxidative stress, typical of this syndrome. MetS is related to an increased risk of cardiovascular diseases and early death, with an important impact on health-care costs. For its clinic management a poly-pharmaceutical therapy is often required, but this can cause side effects and reduce the patient’s compliance. For this reason, finding a valid and alternative therapeutic strategy, natural and free of side effects, could represent a useful tool in the fight the MetS. In this context, the use of functional foods, and the assumption of natural bioactive compounds (NBCs), could exert beneficial effects on body weight, blood pressure and glucose metabolism control, on endothelial damage, on the improvement of lipid profile, on the inflammatory state, and on oxidative stress. This review focuses on the possible beneficial role of NBCs in the prevention and in the clinical management of MetS and its comorbidities.

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Effect of green tea on plasma leptin and ghrelin levels: A systematic review and meta-analysis of randomized controlled clinical trials

Cited by 15 publications

References 48 publications

The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals

The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals

The effect of green tea on inflammatory mediators: A systematic review and meta‐analysis of randomized clinical trials

Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome

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