Gender-Based Differences in a Population-Based Cohort with Celiac Disease: More Alike than Unalike

Jansson-Knodell, Claire; King, Katherine S.; Larson, Joseph J.; Dyke, Carol T. Van; Murray, Joseph A.; Rubio–Tapia, Alberto

doi:10.1007/s10620-017-4835-0

Cited by 41 publications

(37 citation statements)

References 40 publications

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“…Accordingly, current data show that children and adolescents with a higher mean age compared to that of past reports are diagnosed with CD [6]. Predominance of female gender in CD was also reported many times [7]. N.R.…”

Section: Discussionsupporting

confidence: 44%

Влияние Соблюдения Безглютеновой Диеты На Дефицит Витаминов И Микроэлементов У Больных Целиакией

Civan

2021

Mìžnarodnij endokrinologìčnij žurnal

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Background. Celiac disease (CD) is a chronic immune-mediated disorder characterized by growth retardation and malabsorbtion related to mucosal damage and inflammation of small intestine in genetically predisposed people as a result of gluten exposure. In CD treatment, clinical, histological and serological improvement is possible with gluten-free diet. Thus, we aimed to assess the vitamin and trace element levels of CD patients in regard to their compliance with gluten-free diet. Materials and methods. In our study, 77 patients diagnosed with CD were evaluated retrospectively. All individuals were assessed with Marsh classification histopathologically and surveyed when they follow a gluten-free diet. Demographic features, age of disease onset, physical examination findings, anthropometric measurements and laboratory findings along with clinical and laboratory outcomes of patients after a gluten-free diet were compared between compliant to diet and non-compliant to diet groups. Results. A total of 77 individuals, 48 females and 29 males with a diagnosis of CD and mean age of 9.81 ± 4.73 years on admission, were reqruited in our study. Patients were mostly found to have Marsh type 3a (n = 22) and Marsh type 3b (n = 20) histopathologically. The results of serological screening revealed that 40.3 % of people (n = 31) were compliant with diet whereas 59.7 % (n = 46)-non-compliant. Non-compliant group had significantly lower mean vitamin B 12 , vitamin D, folate, zinc and selenium levels compared to compliant group (p = 0.000; 0.000; 0.000; 0.000 and 0.031, respectively). In addition, a significantly higher mean serum total IgA level was detected in non-compliant group in comparison to compliant group (p = 0.027). Conclusions. High efficacy of gluten-free diet in correcting nutritional insufficiencies and deficiencies was shown. Thus, there is no doubt that informing patients and their families about lifelong gluten-free diet in detail is beneficial although this treatment contains many social and practical difficulties.

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Section: Discussionsupporting

confidence: 44%

Влияние Соблюдения Безглютеновой Диеты На Дефицит Витаминов И Микроэлементов У Больных Целиакией

Civan

2021

Mìžnarodnij endokrinologìčnij žurnal

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“…The greater percentage of females among cases than controls can be explained by CD epidemiology. Specifically, CD is more common among females than males 63…”

Section: Discussionmentioning

confidence: 99%

<p>Potential risk factors for celiac disease in childhood: a case-control epidemiological survey</p>

Bittker¹,

Bell²

2019

CEG

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Background: Celiac disease (CD) prevalence has increased significantly in recent decades in some developed countries. Yet the environmental factors in the existing literature do not appear to provide a satisfactory explanation for this increase. Objective: To determine whether nine variables are associated with CD in children. These variables are: incidence of ear infection before 2 years old, courses of antibiotics before 2 years old, duration of breastfeeding, vitamin D drop exposure in infancy, vitamin D supplement exposure between 2–3 years old, age at gluten introduction into the diet, fat content of cow’s milk consumed between 2–3 years old, quantity of cow’s milk consumed between 2–3 years old, and type of water consumed at 2 years old. Methods: An Internet-based survey was conducted among parents living in the US with at least one biological child between 3 and 12 years old. Potential participants were informed about the survey through social media, websites, electronic newsletters, and advertisements. Results: After exclusions, there remained 332 responses associated with children with CD (cases), and 241 responses associated with children who do not have CD (controls). In this data set, skim milk as the primary form of liquid cow’s milk consumed between 2–3 years old (adjusted odds ratio [aOR]=3.556, CI=1.430–10.22, P =0.010), vitamin D drops administered for more than 3 months (aOR=1.749, CI=1.079–2.872, P =0.025), courses of antibiotics (aOR=1.133, CI=1.037–1.244, P =0.007), and incidence of ear infection (aOR=1.183, CI=1.041–1.348, P =0.010) are all associated with CD in children. Conclusions: This study is the first to find an association between skim milk consumption and CD and vitamin D drop use for greater than 3 months and CD. It also adds to evidence that early life exposure to antibiotics and early life infection, specifically ear infection, are associated with CD.

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“…Recruitment in a more gender neutral setting could help to correct this imbalance. However, as no differences in age at diagnosis, presenting symptoms or response to treatment has been reported between males and females with CD [37], it is unlikely sex impacted the results.…”

Section: Discussionmentioning

confidence: 85%

Comparison of DNA methylation profiles from saliva in Coeliac disease and non-coeliac disease individuals

2020

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Background: Coeliac disease (CD) is a autoimmune disease characterised by mucosal inflammation in the small intestine in response to dietary gluten. Genetic factors play a key role with CD individuals carrying either the HLA-DQ2 or HLA-DQ8 haplotype, however these haplotypes are present in half the general population making them necessary but insufficient to cause CD. Epigenetic modifications, including DNA methylation that can change in response to environmental exposure could help to explain how interactions between genes and environmental factors combine to trigger disease development. Identifying changes in DNA methylation profiles in individuals with CD could help discover novel genomic regions involved in the onset and development of CD. Methods: The Illumina InfiniumMethylation450 Beadchip array (HM450) was used to compare DNA methylation profiles in saliva, in CD and non-CD affected individuals. CD individuals who had been diagnosed at least 2 years previously; were on a GFD; and who were currently asymptomatic; were compared to age and sex-matched non-CD affected healthy controls. Bisulphite pyrosequencing was used to validate regions found to be differentially methylated. These regions were also validated in a second larger cohort of CD and non-CD affected individuals. Results: Methylation differences within the HLA region at HLA-DQB1 were identified on HM450 but could not be confirmed with pyrosequencing. Significant methylation differences near the SLC17A3 gene were confirmed on pyrosequencing in the initial pilot cohort. Interestingly pyrosequencing sequencing of these same sites within a second cohort of CD and non-CD affected controls produced significant methylation differences in the opposite direction. Conclusion: Altered DNA methylation profiles appear to be present in saliva in CD individuals. Further work to confirm whether these differences are truly associated with CD is needed.

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Gender-Based Differences in a Population-Based Cohort with Celiac Disease: More Alike than Unalike

Abstract: This study showed that men and women are more alike than unalike when it comes to celiac disease presentation and prevalence of concurrent autoimmune disease.

Cited by 41 publications

References 40 publications

Влияние Соблюдения Безглютеновой Диеты На Дефицит Витаминов И Микроэлементов У Больных Целиакией

Влияние Соблюдения Безглютеновой Диеты На Дефицит Витаминов И Микроэлементов У Больных Целиакией

<p>Potential risk factors for celiac disease in childhood: a case-control epidemiological survey</p>

Comparison of DNA methylation profiles from saliva in Coeliac disease and non-coeliac disease individuals

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