Women's preference for non‐invasive prenatal <scp>DNA</scp> testing versus chromosomal microarray after screening for Down syndrome: a prospective study

Cheng, Yvonne Kwun Yue; Leung, Wing Cheong; Leung, Tak Yeung; Choy, Kwong Wai; Chiu, Rossa W.̉K.; Lo, Tsz‐Kin; Kwok, Ka Yin; Sahota, Daljit Singh

doi:10.1111/1471-0528.15022

Cited by 15 publications

(15 citation statements)

References 41 publications

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“…Both of these studies used contingent conventional screening in which women with 'borderline' screening test results, rather than high-risk, were offered cfDNA testing. The uptake in such women was similar: 80% and 83% in the studies of Chitty et al 22 and Cheng et al 23 , respectively.…”

Section: Assumptions About Uptakesupporting

confidence: 67%

“…The uptake in such women was similar: 80% and 83% in the studies of Chitty et al . and Cheng et al ,. respectively.…”

Section: Model‐predicted Proportion Of Down‐syndrome Cases Detected Asupporting

confidence: 67%

“…Tables 1 and 2 make the simplifying assumption of complete uptake of screening, invasive prenatal diagnosis and cfDNA testing. Seven studies have been published in which women with positive Down-syndrome screening results were offered the choice between invasive prenatal diagnosis and cfDNA testing [17][18][19][20][21][22][23] . These show no consistent overwhelming preference for one or the other test.…”

Section: Assumptions About Uptakementioning

confidence: 99%

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Rethinking second‐trimester Down‐syndrome screening in the cell‐free DNA era

Cuckle

2019

Ultrasound in Obstet & Gyne

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Section: Assumptions About Uptakesupporting

confidence: 67%

“…The uptake in such women was similar: 80% and 83% in the studies of Chitty et al . and Cheng et al ,. respectively.…”

Section: Model‐predicted Proportion Of Down‐syndrome Cases Detected Asupporting

confidence: 67%

Section: Assumptions About Uptakementioning

confidence: 99%

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Rethinking second‐trimester Down‐syndrome screening in the cell‐free DNA era

Cuckle

2019

Ultrasound in Obstet & Gyne

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“…Low or non-response on sensitive issues such as income and wealth has been well documented in the literature. 15 If cost is eliminated as a factor, we would expect the majority of women to choose NIPT as a contingent test, as projected by Lo et al 13 in 2015-2016 and Cheng et al 16 in 2015-2016. In those studies, NIPT was offered as a research expense, and the uptake rates were 62% and 90%, respectively.…”

Section: Discussionmentioning

confidence: 97%

“…In those studies, NIPT was offered as a research expense, and the uptake rates were 62% and 90%, respectively. 13,16 Non-invasive prenatal testing is popular and widely accepted in other parts of the world. The United Kingdom has the same algorithm to manage women screened positive for Down's syndrome, but outside the research arena, NIPT is only available in the private sector at the patient's own expense.…”

Section: Discussionmentioning

confidence: 99%

Second tier non-invasive prenatal testing in a regional prenatal diagnosis service unit: a retrospective analysis and literature review

Chan

Lau

et al. 2020

Hong Kong Med J

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The Hong Kong Hospital Authority has newly introduced a new Down's syndrome screening algorithm that offers free-of-charge noninvasive prenatal testing (NIPT) to women who screen as high risk. In preparation for this publicfunded second tier NIPT service, the present study was conducted to retrospectively analyse women eligible for NIPT and to review the local literature. Methods: Our retrospective study included women screened as high risk for Down's syndrome (adjusted term risk ≥1:250) during the period of 1 January 2015 to 31 December 2016. We performed descriptive statistics and multivariable logistic regression to examine the factors associated with women's choice between NIPT and invasive testing. We also reviewed existing local literature about second tier NIPT. Results: The study included 525 women who screened positive: 67% chose NIPT; 31% chose invasive diagnostic tests; and 2% declined further testing. Our literature review showed that in nonresearch (self-financed NIPT) settings, NIPT uptake rates have been increasing since 2011. Nulliparity, first trimester status, higher education,

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Women’s Attitudes Toward Invasive and Noninvasive Testing When Facing a High Risk of Fetal Down Syndrome

et al. 2019

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Key Points Question What are the attitudes and decision making concerning invasive and noninvasive prenatal testing in women at high risk of fetal Down syndrome? Findings In a survey study of 2436 pregnant women in France participating in a randomized clinical trial, 4 clusters were identified with different attitudes toward risk taking and extent of information seeking. Decision making was in line with attitudes, and clinical and socioeconomic factors were likely associated with the attitudes identified. Meaning Aversion to ambiguity generated by incomplete information from noninvasive testing as well as aversion to risk of pregnancy loss due to invasive testing played a major role in shaping attitudes and decision making; therefore, pregnant women should receive extensive information on targeted abnormalities by both tests to aid informed decision making.

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Women's preference for non‐invasive prenatal DNA testing versus chromosomal microarray after screening for Down syndrome: a prospective study

Abstract: 60% of pregnant Chinese women prefer NIPT over CMA when screened as high risk for Down syndrome.

Cited by 15 publications

References 41 publications

Rethinking second‐trimester Down‐syndrome screening in the cell‐free DNA era

Rethinking second‐trimester Down‐syndrome screening in the cell‐free DNA era

Second tier non-invasive prenatal testing in a regional prenatal diagnosis service unit: a retrospective analysis and literature review

Women’s Attitudes Toward Invasive and Noninvasive Testing When Facing a High Risk of Fetal Down Syndrome

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