Gut remediation: a potential approach to reducing chromium accumulation using Lactobacillus plantarum TW1-1

Wu, Gaofeng; Xiao, Xiongxin; Feng, Ping; Xie, Fuquan; Yu, Zhengsheng; Wang, Yuan; Liu, Pu

doi:10.1038/s41598-017-15216-9

Cited by 50 publications

(50 citation statements)

References 57 publications

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“…Likewise, various Lactobacillus spp. can accumulate copper (49), cadmium (50)(51)(52), aluminum (53), and chromium (54), which suggests that members of this genus have the potential to be administered as probiotics to reduce metal burden in the host.…”

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confidence: 99%

Cadmium and Selenate Exposure Affects the Honey Bee Microbiome and Metabolome, and Bee-Associated Bacteria Show Potential for Bioaccumulation

Rothman

Leger

Kirkwood

et al. 2019

Appl Environ Microbiol

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Honey bees are important insect pollinators used heavily in agriculture and can be found in diverse environments. Bees may encounter toxicants such as cadmium and selenate by foraging on plants growing in contaminated areas, which can result in negative health effects. Honey bees are known to have a simple and consistent microbiome that conveys many benefits to the host, and toxicant exposure may impact this symbiotic microbial community. We used 16S rRNA gene sequencing to assay the effects that sublethal cadmium and selenate treatments had over 7 days and found that both treatments significantly but subtly altered the composition of the bee microbiome. Next, we exposed bees to cadmium and selenate and then used untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics to show that chemical exposure changed the bees' metabolite profiles and that compounds which may be involved in detoxification, proteolysis, and lipolysis were more abundant in treatments. Finally, we exposed several strains of bee-associated bacteria in liquid culture and found that each strain removed cadmium from its medium but that only Lactobacillus Firm-5 microbes assimilated selenate, indicating the possibility that these microbes may reduce the metal and metalloid burden on their host. Overall, our report shows that metal and metalloid exposure can affect the honey bee microbiome and metabolome and that strains of bee-associated bacteria can bioaccumulate these toxicants. IMPORTANCE Bees are important insect pollinators that may encounter environmental pollution when foraging upon plants grown in contaminated areas. Despite the pervasiveness of pollution, little is known about the effects of these toxicants on honey bee metabolism and their symbiotic microbiomes. Here, we investigated the impact of selenate and cadmium exposure on the gut microbiome and metabolome of honey bees. We found that exposure to these chemicals subtly altered the overall composition of the bees' microbiome and metabolome and that exposure to toxicants may negatively impact both host and microbe. As the microbiome of animals can reduce mortality upon metal or metalloid challenge, we grew bee-associated bacteria in media spiked with selenate or cadmium. We show that some bacteria can remove these toxicants from their media in vitro and suggest that bacteria may reduce metal burden in their hosts.

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confidence: 99%

Cadmium and Selenate Exposure Affects the Honey Bee Microbiome and Metabolome, and Bee-Associated Bacteria Show Potential for Bioaccumulation

Rothman

Leger

Kirkwood

et al. 2019

Appl Environ Microbiol

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“…Treatment of chromium-induced systemic contact dermatitis may be conducted in several approaches including managing diets and lifestyles by gut remediation and avoiding the food and sources that contain chromium; systemic or topical treatment using immune-suppressants such as corticosteroid; phototherapy; and hyposensitization therapy [80,81]. Sharma developed a guideline for the preparation of low chromate diet that could help in controlling daily chromium consumption from food and ameliorating skin condition [82].…”

Section: Systemic Contact Dermatitismentioning

confidence: 99%

Dermatologic Toxicities and Biological Activities of Chromium

Jumina¹,

Harizal²

2021

Trace Metals in the Environment - New Approaches and Recent Advances

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Chromium is a versatile metal with various industrial applications and biological activities. However, as a transition metal, this element forms several species, i.e. oxidation states of −4 to +6, with different degrees of toxicities that affect ecosystems and organisms including human beings. The skin is the outermost organ that usually interacts directly with chromium species in nature. These contact and interaction induce the formation of several acute and chronic negative effects including contact dermatitis, skin cancer, allergy, etc. In this chapter, toxicity and biological activity of several chromium species, such as chromium zero-valent, trivalent, hexavalent, will be reviewed to obtain better comprehension in chromium toxicity. Sources and routes of exposure, toxicity and possible treatment, and biological activity on the skin are arranged and explained systematically.

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“…Cr(VI) can be reduced to Cr(III), which is poorly absorbed, less toxic, and considered an essential trace element for humans 17 . In a previous study, an L. plantarum strain with strong Cr(VI)-reducing ability effectively diminished Cr accumulation in mouse tissues and enhanced the Cr(VI)-reducing ability of fecal microbes 6 . Hence, we hypothesize that the inherent Cr(VI)detoxifying gene activity of commensal intestinal microorganisms is repressed under Cr(VI) stress, and could be recovered by some probiotics, resulting in enhanced capacity of the GM to combat Cr(VI).…”

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confidence: 90%

“…Phytoremediation has been generally accepted for decontamination of HMs-polluted soils compared with conventional physical-chemical remediation, due to its costeffective, environment-and eco-friendly on-site application 5 . However, it may be less effective considering the vast area of pollution and the long remediation duration required for plant growth 6 . In the near future, humans will be inevitably exposed to HM contaminated foods, especially in developing countries.…”

mentioning

confidence: 99%

“…A pilot study in an atrisk human population in Tanzania demonstrated the potential of Lactobacillus rhamnosus GR-1 supplemented yogurt in lowering the blood levels of toxic metals 7 . Similarly, several L. plantarum strains were found effective in mitigating the toxic effects of ingested cadmium, lead, and chromate in mice via multiple routes, mainly by intestinal sequestration and intestinal barrier protection 6,8,9 . However, as indicated in recent reports, the number of probiotic strains that colonize the gastrointestinal tract is extremely limited, and thus, it is unknown how the restricted number of probiotics exert their influence to achieve protective effects against HM pollutants.…”

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confidence: 99%

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Tibet plateau probiotic mitigates chromate toxicity in mice by alleviating oxidative stress in gut microbiota

Feng

Han

et al. 2020

Commun Biol

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Heavy metal contamination in food endangers human health. Probiotics can protect animals and human against heavy metals, but the detoxification mechanism has not been fully clarified. Here, mice were supplemented with Pediococcus acidilactici strain BT36 isolated from Tibetan plateau yogurt, with strong antioxidant activity but no chromate reduction ability for 20 days to ensure gut colonization. Strain BT36 decreased chromate accumulation, reduced oxidative stress, and attenuated histological damage in the liver of mice. 16S rRNA and metatranscriptome sequencing analysis of fecal microbiota showed that BT36 reversed Cr (VI)-induced changes in gut microbial composition and metabolic activity. Specifically, BT36 recovered the expressions of 788 genes, including 34 inherent Cr remediation-relevant genes. Functional analysis of 10 unannotated genes regulated by BT36 suggested the existence of a new Cr(VI)-reduction gene in the gut microbiota. Thus, BT36 can modulate the gut microbiota in response to Cr(VI) induced oxidative stress and protect against Cr toxicity.

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Gut remediation: a potential approach to reducing chromium accumulation using Lactobacillus plantarum TW1-1

Cited by 50 publications

References 57 publications

Cadmium and Selenate Exposure Affects the Honey Bee Microbiome and Metabolome, and Bee-Associated Bacteria Show Potential for Bioaccumulation

Cadmium and Selenate Exposure Affects the Honey Bee Microbiome and Metabolome, and Bee-Associated Bacteria Show Potential for Bioaccumulation

Dermatologic Toxicities and Biological Activities of Chromium

Tibet plateau probiotic mitigates chromate toxicity in mice by alleviating oxidative stress in gut microbiota

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