A longitudinal functional magnetic resonance imaging study of task control circuits and bulimic symptoms over adolescence

Cyr, Marilyn; Fontaine, Bertrand; Stefan, Mihaela; Terranova, Kate; Kopala‐Sibley, Daniel C.; Attia, Evelyn; Marsh, Rachel

doi:10.1111/jcpp.12840

Cited by 6 publications

(2 citation statements)

References 40 publications

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“…Whittle et al (2013) found that psychopathology in early adolescence mediated effects of childhood maltreatment on the development of amygdala and hippocampal volumes. Another study, in adolescent females, showed that increased symptoms of bulimia nervosa predicted change over time in brain function, assessed via fMRI, during a cognitive control/conflict resolution task (a Simon task), in the inferior frontal cortex (Cyr, Fontaine, et al, 2017). However, brain function did not predict the development of bulimia symptoms.…”

Section: Evidence For Stress-generation Modelsmentioning

confidence: 99%

Integrating dynamic interactionism into the brain–stress–psychopathology relationship.

Kopala‐Sibley¹,

Stein²,

Bray³

et al. 2021

Canadian Psychology / Psychologie canadienne

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Public Significance StatementMuch research has examined associations between brain structure or function and psychopathology. However, less research has examined dynamic interactional models of the brain-stresspsychopathology relationship. In this paper, drawing on a long history of personality-stresspsychopathology research, we selectively review clinical neuroscience evidence regarding different models of the brain-stress-psychopathology relationship and propose a dynamic-interactionist perspective of this relationship.

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Section: Evidence For Stress-generation Modelsmentioning

confidence: 99%

Integrating dynamic interactionism into the brain–stress–psychopathology relationship.

Kopala‐Sibley¹,

Stein²,

Bray³

et al. 2021

Canadian Psychology / Psychologie canadienne

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“…Participants completed the Simon task (previously described). [49][50][51] Briefly, participants were presented with a leftward or rightward pointing arrow on each trial that was congruent or incongruent with its position (left or right) on the screen. They were instructed to respond as quickly and accurately as possible to the direction of the arrow by pressing a button on a response box using the index finger for left and the middle finger for right.…”

Section: Functional Magnetic Resonance Imaging Paradigmmentioning

confidence: 99%

Deficient Functioning of Frontostriatal Circuits During the Resolution of Cognitive Conflict in Cannabis-Using Youth

Cyr

Tau

Fontaine

et al. 2019

Journal of the American Academy of Child & Adolescent Psych

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Objective: Disturbances in self-regulatory control are involved in the initiation and maintenance of addiction, including cannabis use disorder. In adults, long-term cannabis use is associated with disturbances in frontostriatal circuits during tasks that require the engagement of self-regulatory control, including the resolution of cognitive conflict. Understudied are the behavioral and neural correlates of these processes earlier in the course of cannabis use disentangled from effects of long-term use. The present study investigated the functioning of frontostriatal circuits during the resolution of cognitive conflict in cannabis-using youth. Method: Functional magnetic resonance imaging data were acquired from 28 cannabis-using youth and 32 age-matched healthy participants during the performance of a Simon task. General linear modeling was used to compare patterns of brain activation during correct responses to conflict stimuli across groups. Psychophysiologic interaction analyses were used to examine conflict-related frontostriatal connectivity across groups. Associations of frontostriatal activation and connectivity with cannabis use measures were explored. Results: Decreased conflict-related activity was detected in cannabis-using versus healthy control youth in frontostriatal regions, including the ventromedial prefrontal cortex, striatum, pallidum, and thalamus. Frontostriatal connectivity did not differ across groups, but negative connectivity between the ventromedial prefrontal cortex and striatum was detected in the 2 groups. Conclusion: These findings are consistent with previous reports of cannabis-associated disturbances in frontostriatal circuits in adults and point to the specific influence of cannabis on neurodevelopmental changes in youth. Future studies should examine whether frontostriatal functioning is a reliable marker of cannabis use disorder severity and a potential target for circuit-based interventions.

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Abnormal fronto‐striatal activation as a marker of threshold and subthreshold Bulimia Nervosa

Cyr

Yang

Horga

et al. 2018

Human Brain Mapping

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This study aimed to determine whether functional disturbances in fronto-striatal control circuits characterize adolescents with Bulimia Nervosa (BN) spectrum eating disorders regardless of clinical severity. FMRI was used to assess conflict-related brain activations during performance of a Simon task in two samples of adolescents with BN symptoms compared with healthy adolescents. The BN samples differed in the severity of their clinical presentation, illness duration and age. Multi-voxel pattern analyses (MVPAs) based on machine learning were used to determine whether patterns of fronto-striatal activation characterized adolescents with BN spectrum disorders regardless of clinical severity, and whether accurate classification of less symptomatic adolescents (subthreshold BN; SBN) could be achieved based on patterns of activation in adolescents who met DSM5 criteria for BN. MVPA classification analyses revealed that both BN and SBN adolescents could be accurately discriminated from healthy adolescents based on fronto-striatal activation. Notably, the patterns detected in more severely ill BN compared with healthy adolescents accurately discriminated less symptomatic SBN from healthy adolescents. Deficient activation of fronto-striatal circuits can characterize BN early in its course, when clinical presentations are less severe, perhaps pointing to circuit-based disturbances as useful biomarker or risk factor for the disorder, and a tool for understanding its developmental trajectory, as well as the development of early interventions.

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A longitudinal functional magnetic resonance imaging study of task control circuits and bulimic symptoms over adolescence

Cited by 6 publications

References 40 publications

Integrating dynamic interactionism into the brain–stress–psychopathology relationship.

Integrating dynamic interactionism into the brain–stress–psychopathology relationship.

Deficient Functioning of Frontostriatal Circuits During the Resolution of Cognitive Conflict in Cannabis-Using Youth

Abnormal fronto‐striatal activation as a marker of threshold and subthreshold Bulimia Nervosa

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