Microwave assisted synthesis of binary grafted psyllium and its utility in anticancer formulation

Kumar, Deepak; Pandey, Jyoti; Kumar, Praveen

doi:10.1016/j.carbpol.2017.09.093

Cited by 25 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The XRD pattern of psyllium exhibits a broad characteristic peak at 20 (2θ), indicating the amorphous nature of pure psyllium mucilage as shown in Figure 6a. In the XRD pattern of cross-linked Psy-g-Poly(An-co-AA) as shown in Figure 6b, 4 , which show that the QNP is also highly crystalline in nature. 43…”

Section: X-ray Diffractionmentioning

confidence: 95%

“…The bands at 1644 cm À1 and 1033.85 cm À1 are attributed to the C O C stretching vibrations. 4 The FTIR spectra of cross-linked Psy-g-Poly(An-co-AA) show characteristic peaks at 3397 cm À1 , due to stretching vibration of OH and a small peak at 2929 cm À1 due to the C H stretching vibrations and the other main characteristics peaks were identified as 2152 cm À1 (C N stretching of nitrile), 1730 cm À1 (carboxylic acid), 1645 cm À1 (C═O stretching of amide-I) 1381.6 cm À1 (N H in-plane bending of amide-II) and 1252.3 cm À1 (stretching of amide-III). The band at 1047.2 cm À1 is attributed to the C O C stretching vibrations as shown in Figure 4b.…”

Section: Ftir Spectramentioning

confidence: 99%

“…DTA curve of cross-linked Psy-g-Poly (An-co-AA) has a characteristics peak at 416 C, which clearly indicates that the thermal decomposition of modified psyllium was exothermic. 4,44 The TGA study indicates that the thermal stability of psyllium decreases after the grafting of acrylic acid and acrylonitrile on its backbone and crosslinking of the grafted polymer.…”

Section: Thermal Studymentioning

confidence: 99%

“…Kumar et al synthesized the binary grafted psyllium for anticancer formulation through microwave irradiation process. 4 Pal et al synthesized the pH-sensitive cross-linked guar gum-g-poly(acrylic acid-co-acrylonitrile) for the delivery of thymoquinone against inflammation by using the microwave-assisted method. The synthesized cross-link material was used to obtain the nanoparticle of thymoquinone for drug delivery applications.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Synthesis of pH‐sensitive grafted psyllium: Encapsulation of quercetin for colon cancer treatment

Kumar

Gautam

Kundu

2021

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

The pH-sensitive polymeric materials are the current need of time in targeted drug delivery applications. The pH-sensitive cross-linked psyllium grafted-poly (acrylonitrile-co-acrylic acid) [Psy-g-Poly (An-co-AA)] was synthesized by using ceric ammonium nitrate (CAN) redox initiator via chemical grafting process for colon cancer treatment. The synthesized material [Psy-g-Poly (An-co-AA)] was characterized by nuclear magnetic resonance, Fourier transform infrared, scanning electron microscopy, X-ray diffraction Zeta potential, and thermal gravimetric analysis. Furthermore, quercetin (QPN) drug was encapsulated in cross-linked grafted psyllium preparing nanoparticles of encapsulated QPN via the sonication technique for controlled release of QPN and testing of in vitro anticancer and antioxidant activities. The anticancer activity of QNP and QPN were studied on human cell line (HCT-15) and it was observed that QNP also exhibited excellent anticancer and antioxidant activity as compared to only QPN. QNP showed maximal swelling at pH-7 and demonstrated maximum QPN release (93%) at the pH of the intestinal fluid (pH-7.4). The drug release kinetic data followed the Korsmeyer-Peppas model (R 2 = 0.9808) kinetic model, indicating the mechanism of drug release from QNP was non-Fickian diffusion. Furthermore, pH-specific QPN release behavior of Psy-g-Poly (An-co-AA) can be utilized for colon targeted drug delivery.

show abstract

Section: X-ray Diffractionmentioning

confidence: 95%

Section: Ftir Spectramentioning

confidence: 99%

Section: Thermal Studymentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Synthesis of pH‐sensitive grafted psyllium: Encapsulation of quercetin for colon cancer treatment

Kumar

Gautam

Kundu

2021

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

show abstract

“…The final product, the grafted gum, was then dried at 40°C under vacuum until it attained a stable weight and was processed into fine particles. [8,9] C-Pc was incorporated into the graft polymer at a 1% wt concentration to prepare drugloaded hydrogel. The polymer was dissolved in distilled water under continuous agitation and left overnight for complete dissolution.…”

Section: Preparation Of Hydrogelmentioning

confidence: 99%

Development and Evaluation of Phycocyanin-Infused Hydrogel Topical Formulations for Wound Healing

Alka,

Saraf

2024

Int. J. Pharm. Sci. Drug Res.

View full text Add to dashboard Cite

Wound healing is a complex biological process impaired by several factors, and conventional treatments often result in undesirable side effects. Natural compounds have emerged as favourable alternatives due to their reduced side effects. C-phycocyanin (C-Pc), a natural phycobiliprotein derived from Spirulina platensis, shows promise in wound healing but is hindered by poor stability and low bioavailability. This study aimed to develop a hydrogel-based delivery system for C-Pc to enhance its stability and therapeutic efficacy in wound healing. We synthesized a grafted gum hydrogel to encapsulate C-Pc, ensuring its sustained release. The hydrogel’s physical properties, including clarity, pH, spreadability, and rheological behaviour, were characterized. The encapsulation efficiency, in vitro release profile, antioxidant activity, and adhesion were assessed. Furthermore, the hydrogel’s impact on wound healing was evaluated through in vivo studies and assessments of skin irritation potential. The optimized hydrogel demonstrated excellent physical stability, appropriate viscosity, and significant bioadhesive properties, making it suitable for topical application. The encapsulated C-Pc exhibited a controlled release, enhanced antioxidant activity, and greater wound-healing efficacy than free C-Pc. In vivo studies confirmed accelerated wound closure with no irritation or allergy, suggesting high biocompatibility and therapeutic potential. Developing a C-Pc encapsulated hydrogel presents a promising approach to improving wound care. This innovative approach not only stabilizes C-Pc but also enhances its healing properties, providing a safe and effective option for patients. This study paves the way for a novel formulation with translatory potential.

show abstract

Hydrogel Materials for Biomedical Application: A Review

Надтока

Virych

Krysa

et al. 2023

Springer Proceedings in Physics

View full text Add to dashboard Cite

Microwave assisted synthesis of binary grafted psyllium and its utility in anticancer formulation

Cited by 25 publications

References 30 publications

Synthesis of pH‐sensitive grafted psyllium: Encapsulation of quercetin for colon cancer treatment

Synthesis of pH‐sensitive grafted psyllium: Encapsulation of quercetin for colon cancer treatment

Development and Evaluation of Phycocyanin-Infused Hydrogel Topical Formulations for Wound Healing

Hydrogel Materials for Biomedical Application: A Review

Contact Info

Product

Resources

About